| Tag | Content |
|---|---|
| UniProt Accession | HSPB1_MOUSE; P14602; |
| Entrez ID | 15507 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Heat shock protein beta-1 (HspB1) (Growth-related 25 kDa protein) (Heat shock 25 kDa protein) (HSP 25) (Heat shock 27 kDa protein) (HSP 27) (p25) |
| Gene Name | Hspb1; Hsp25; Hsp27 |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization (PubMed:17661394). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity). |
| Sequence (Fasta) | MTERRVPFSL LRSPSWEPFR DWYPAHSRLF DQAFGVPRLP DEWSQWFSAA GWPGYVRPLP 60 AATAEGPAAV TLAAPAFSRA LNRQLSSGVS EIRQTADRWR VSLDVNHFAP EELTVKTKEG 120 VVEITGKHEE RQDEHGYISR CFTRKYTLPP GVDPTLVSSS LSPEGTLTVE APLPKAVTQS 180 AEITIPVTFE ARAQIGGPEA GKSEQSGAK |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 19) (view all) | MESH:C538231
; Adenocarcinoma of lung MESH:D006528 ; Carcinoma, Hepatocellular MESH:D002292 ; Carcinoma, Renal Cell MESH:D002294 ; Carcinoma, Squamous Cell MESH:D002312 ; Cardiomyopathy, Hypertrophic MESH:C535413 ; Charcot-Marie-Tooth disease, Type 2F |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 10) (view all) | 13 VPFSLLRSPSWEPFR dbPAF
139 QDEHGYISRCFTRKY dbPAF 146 SRCFTRKYTLPPGVD dbPAF 147 RCFTRKYTLPPGVDP dbPAF 15 FSLLRSPSWEPFRDW dbPAF 71 AEGPAAVTLAAPAFS dbPAF |
| Ubiquitination (count: 4) | 116 APEELTVKTKEGVVE PLMD
118 EELTVKTKEGVVEIT PLMD 145 ISRCFTRKYTLPPGV PLMD 202 IGGPEAGKSEQSGAK PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |