| Tag | Content |
|---|---|
| UniProt Accession | EF2_HUMAN; P13639; |
| Entrez ID | 1938 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Elongation factor 2 (EF-2) |
| Gene Name | EEF2; EF2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. |
| Sequence (Fasta) | MVNFTVDQIR AIMDKKANIR NMSVIAHVDH GKSTLTDSLV CKAGIIASAR AGETRFTDTR 60 KDEQERCITI KSTAISLFYE LSENDLNFIK QSKDGAGFLI NLIDSPGHVD FSSEVTAALR 120 VTDGALVVVD CVSGVCVQTE TVLRQAIAER IKPVLMMNKM DRALLELQLE PEELYQTFQR 180 IVENVNVIIS TYGEGESGPM GNIMIDPVLG TVGFGSGLHG WAFTLKQFAE MYVAKFAAKG 240 EGQLGPAERA KKVEDMMKKL WGDRYFDPAN GKFSKSATSP EGKKLPRTFC QLILDPIFKV 300 FDAIMNFKKE ETAKLIEKLD IKLDSEDKDK EGKPLLKAVM RRWLPAGDAL LQMITIHLPS 360 PVTAQKYRCE LLYEGPPDDE AAMGIKSCDP KGPLMMYISK MVPTSDKGRF YAFGRVFSGL 420 VSTGLKVRIM GPNYTPGKKE DLYLKPIQRT ILMMGRYVEP IEDVPCGNIV GLVGVDQFLV 480 KTGTITTFEH AHNMRVMKFS VSPVVRVAVE AKNPADLPKL VEGLKRLAKS DPMVQCIIEE 540 SGEHIIAGAG ELHLEICLKD LEEDHACIPI KKSDPVVSYR ETVSEESNVL CLSKSPNKHN 600 RLYMKARPFP DGLAEDIDKG EVSARQELKQ RARYLAEKYE WDVAEARKIW CFGPDGTGPN 660 ILTDITKGVQ YLNEIKDSVV AGFQWATKEG ALCEENMRGV RFDVHDVTLH ADAIHRGGGQ 720 IIPTARRCLY ASVLTAQPRL MEPIYLVEIQ CPEQVVGGIY GVLNRKRGHV FEESQVAGTP 780 MFVVKAYLPV NESFGFTADL RSNTGGQAFP QCVFDHWQIL PGDPFDNSSR PSQVVAETRK 840 RKGLKEGIPA LDNFLDKL 859 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 9) (view all) | MESH:D000230
; Adenocarcinoma MESH:D001943 ; Breast Neoplasms MESH:D002292 ; Carcinoma, Renal Cell MESH:D008175 ; Lung Neoplasms MESH:D009361 ; Neoplasm Invasiveness MESH:D009362 ; Neoplasm Metastasis |
| DisGeNet (Curated) (count: 21) (view all) | C0001418; Adenocarcinoma
C0007134; Renal Cell Carcinoma C0013362; Dysarthria C0024121; Lung Neoplasms C0027626; Neoplasm Invasiveness C0027627; Neoplasm Metastasis |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 50) (view all) | 175 QLEPEELYQTFQRIV dbPAF
177 EPEELYQTFQRIVEN dbPAF 197 STYGEGESGPMGNIM dbPAF 23 KANIRNMSVIAHVDH dbPAF 265 KKLWGDRYFDPANGK dbPAF 279 KFSKSATSPEGKKLP dbPAF |
| Acetylation (count: 36) (view all) | 152 QAIAERIKPVLMMNK PLMD
159 KPVLMMNKMDRALLE PLMD 235 FAEMYVAKFAAKGEG PLMD 239 YVAKFAAKGEGQLGP PLMD 252 GPAERAKKVEDMMKK PLMD 258 KKVEDMMKKLWGDRY PLMD |
| Ubiquitination (count: 53) (view all) | 152 QAIAERIKPVLMMNK PLMD
159 KPVLMMNKMDRALLE PLMD 16 IRAIMDKKANIRNMS PLMD 235 FAEMYVAKFAAKGEG PLMD 239 YVAKFAAKGEGQLGP PLMD 251 LGPAERAKKVEDMMK PLMD |
| Sumoylation (count: 4) | 239 YVAKFAAKGEGQLGP PLMD
322 LIEKLDIKLDSEDKD PLMD 512 VRVAVEAKNPADLPK PLMD 529 EGLKRLAKSDPMVQC PLMD |
| Glycation (count: 2) | 400 PLMMYISKMVPTSDK PLMD
407 KMVPTSDKGRFYAFG PLMD |
| Malonylation (count: 14) (view all) | 235 FAEMYVAKFAAKGEG PLMD
239 YVAKFAAKGEGQLGP PLMD 251 LGPAERAKKVEDMMK PLMD 252 GPAERAKKVEDMMKK PLMD 272 YFDPANGKFSKSATS PLMD 275 PANGKFSKSATSPEG PLMD |
| Methylation (count: 3) | 407 KMVPTSDKGRFYAFG PLMD
525 PKLVEGLKRLAKSDP PLMD 594 SNVLCLSKSPNKHNR PLMD |
| Succinylation (count: 14) (view all) | 239 YVAKFAAKGEGQLGP PLMD
258 KKVEDMMKKLWGDRY PLMD 275 PANGKFSKSATSPEG PLMD 283 SATSPEGKKLPRTFC PLMD 308 FDAIMNFKKEETAKL PLMD 318 ETAKLIEKLDIKLDS PLMD |