| Tag | Content |
|---|---|
| UniProt Accession | CADH1_HUMAN; P12830; |
| Entrez ID | 999 |
| GenBank Protein ID | NM_001317184.1; NM_001317185.1; NM_001317186.1; NM_004360.4; |
| GenBank Nucleotide ID | NP_001304113.1; NP_001304114.1; NP_001304115.1; NP_004351.1; |
| Protein Name | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] |
| Gene Name | CDH1; CDHE; UVO |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.;E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. |
| Sequence (Fasta) | MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC 60 TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG 120 HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS 180 NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN 240 AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI 300 AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT 360 AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG 420 GQFVVTTNPV NNDGILKTAK GLDFEAKQQY ILHVAVTNVV PFEVSLTTST ATVTVDVLDV 480 NEAPIFVPPE KRVEVSEDFG VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG 540 AISTRAELDR EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI 600 FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI ILKPKMALEV 660 GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP VEAGLQIPAI LGILGGILAL 720 LILILLLLLF LRRRAVVKEP LLPPEDDTRD NVYYYDEEGG GEEDQDFDLS QLHRGLDARP 780 EVTRNDVAPT LMSVPRYLPR PANPDEIGNF IDENLKAADT DPTAPPYDSL LVFDYEGSGS 840 EAASLSSLNS SESDKDQDYD YLNEWGNRFK KLADMYGGGE DD 883 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | lobular breast, gastric gastric familial gastric carcinoma |
| CTD (Curated) (count: 31) (view all) | MESH:D001943
; Breast Neoplasms MESH:D002277 ; Carcinoma MESH:D003528 ; Carcinoma, Adenoid Cystic MESH:D018270 ; Carcinoma, Ductal, Breast MESH:D018275 ; Carcinoma, Lobular MESH:D002294 ; Carcinoma, Squamous Cell |
| HGMD (count: 96) (view all) | CD993839; Gastric cancer; Small deletions
CD994007; Gastric cancer; Small deletions CD052979; Gastric cancer; Small deletions CD021013; Gastric cancer; Small deletions CD071300; Gastric cancer; Small deletions CD021014; Gastric cancer; Small deletions |
| GWASdb (count: 5) | rs9929218; Colorectal cancer; colorectal cancer
rs9929218; Nasopharyngeal carcinoma; nasopharynx carcinoma rs1862748; Colorectal cancer; colorectal cancer rs10431923; Serum metabolites; Null rs3785076; Corneal structure; corneal disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 26) (view all) | 211 VFIIERETGWLKVTE dbPAF
217 ETGWLKVTEPLDRER dbPAF 330 TGVISVVTTGLDRES dbPAF 394 NEANVVITTLKVTDA dbPAF 395 EANVVITTLKVTDAD dbPAF 576 DNGSPVATGTGTLLL dbPAF |
| Ubiquitination (count: 2) | 738 LRRRAVVKEPLLPPE PLMD
871 EWGNRFKKLADMYGG PLMD |