Tag | Content |
---|---|
UniProt Accession | FA5_HUMAN; P12259; |
Entrez ID | 2153 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain] |
Gene Name | F5 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
Sequence (Fasta) | MFPGCPRLWV LVVLGTSWVG WGSQGTEAAQ LRQFYVAAQG ISWSYRPEPT NSSLNLSVTS 60 FKKIVYREYE PYFKKEKPQS TISGLLGPTL YAEVGDIIKV HFKNKADKPL SIHPQGIRYS 120 KLSEGASYLD HTFPAEKMDD AVAPGREYTY EWSISEDSGP THDDPPCLTH IYYSHENLIE 180 DFNSGLIGPL LICKKGTLTE GGTQKTFDKQ IVLLFAVFDE SKSWSQSSSL MYTVNGYVNG 240 TMPDITVCAH DHISWHLLGM SSGPELFSIH FNGQVLEQNH HKVSAITLVS ATSTTANMTV 300 GPEGKWIISS LTPKHLQAGM QAYIDIKNCP KKTRNLKKIT REQRRHMKRW EYFIAAEEVI 360 WDYAPVIPAN MDKKYRSQHL DNFSNQIGKH YKKVMYTQYE DESFTKHTVN PNMKEDGILG 420 PIIRAQVRDT LKIVFKNMAS RPYSIYPHGV TFSPYEDEVN SSFTSGRNNT MIRAVQPGET 480 YTYKWNILEF DEPTENDAQC LTRPYYSDVD IMRDIASGLI GLLLICKSRS LDRRGIQRAA 540 DIEQQAVFAV FDENKSWYLE DNINKFCENP DEVKRDDPKF YESNIMSTIN GYVPESITTL 600 GFCFDDTVQW HFCSVGTQNE ILTIHFTGHS FIYGKRHEDT LTLFPMRGES VTVTMDNVGT 660 WMLTSMNSSP RSKKLRLKFR DVKCIPDDDE DSYEIFEPPE STVMATRKMH DRLEPEDEES 720 DADYDYQNRL AAALGIRSFR NSSLNQEEEE FNLTALALEN GTEFVSSNTD IIVGSNYSSP 780 SNISKFTVNN LAEPQKAPSH QQATTAGSPL RHLIGKNSVL NSSTAEHSSP YSEDPIEDPL 840 QPDVTGIRLL SLGAGEFKSQ EHAKHKGPKV ERDQAAKHRF SWMKLLAHKV GRHLSQDTGS 900 PSGMRPWEDL PSQDTGSPSR MRPWKDPPSD LLLLKQSNSS KILVGRWHLA SEKGSYEIIQ 960 DTDEDTAVNN WLISPQNASR AWGESTPLAN KPGKQSGHPK FPRVRHKSLQ VRQDGGKSRL 1020 KKSQFLIKTR KKKKEKHTHH APLSPRTFHP LRSEAYNTFS ERRLKHSLVL HKSNETSLPT 1080 DLNQTLPSMD FGWIASLPDH NQNSSNDTGQ ASCPPGLYQT VPPEEHYQTF PIQDPDQMHS 1140 TSDPSHRSSS PELSEMLEYD RSHKSFPTDI SQMSPSSEHE VWQTVISPDL SQVTLSPELS 1200 QTNLSPDLSH TTLSPELIQR NLSPALGQMP ISPDLSHTTL SPDLSHTTLS LDLSQTNLSP 1260 ELSQTNLSPA LGQMPLSPDL SHTTLSLDFS QTNLSPELSH MTLSPELSQT NLSPALGQMP 1320 ISPDLSHTTL SLDFSQTNLS PELSQTNLSP ALGQMPLSPD PSHTTLSLDL SQTNLSPELS 1380 QTNLSPDLSE MPLFADLSQI PLTPDLDQMT LSPDLGETDL SPNFGQMSLS PDLSQVTLSP 1440 DISDTTLLPD LSQISPPPDL DQIFYPSESS QSLLLQEFNE SFPYPDLGQM PSPSSPTLND 1500 TFLSKEFNPL VIVGLSKDGT DYIEIIPKEE VQSSEDDYAE IDYVPYDDPY KTDVRTNINS 1560 SRDPDNIAAW YLRSNNGNRR NYYIAAEEIS WDYSEFVQRE TDIEDSDDIP EDTTYKKVVF 1620 RKYLDSTFTK RDPRGEYEEH LGILGPIIRA EVDDVIQVRF KNLASRPYSL HAHGLSYEKS 1680 SEGKTYEDDS PEWFKEDNAV QPNSSYTYVW HATERSGPES PGSACRAWAY YSAVNPEKDI 1740 HSGLIGPLLI CQKGILHKDS NMPMDMREFV LLFMTFDEKK SWYYEKKSRS SWRLTSSEMK 1800 KSHEFHAING MIYSLPGLKM YEQEWVRLHL LNIGGSQDIH VVHFHGQTLL ENGNKQHQLG 1860 VWPLLPGSFK TLEMKASKPG WWLLNTEVGE NQRAGMQTPF LIMDRDCRMP MGLSTGIISD 1920 SQIKASEFLG YWEPRLARLN NGGSYNAWSV EKLAAEFASK PWIQVDMQKE VIITGIQTQG 1980 AKHYLKSCYT TEFYVAYSSN QINWQIFKGN STRNVMYFNG NSDASTIKEN QFDPPIVARY 2040 IRISPTRAYN RPTLRLELQG CEVNGCSTPL GMENGKIENK QITASSFKKS WWGDYWEPFR 2100 ARLNAQGRVN AWQAKANNNK QWLEIDLLKI KKITAIITQG CKSLSSEMYV KSYTIHYSEQ 2160 GVEWKPYRLK SSMVDKIFEG NTNTKGHVKN FFNPPIISRF IRVIPKTWNQ SIALRLELFG 2220 CDIY 2225 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 20) (view all) | MESH:D011125
; Adenomatous Polyposis Coli MESH:D001778 ; Blood Coagulation Disorders MESH:D002545 ; Brain Ischemia MESH:D006502 ; Budd-Chiari Syndrome MESH:D002544 ; Cerebral Infarction MESH:D003110 ; Colonic Neoplasms |
DisGeNet (Curated) (count: 49) (view all) | C0000737; Abdominal Pain
C0003962; Ascites C0005779; Blood Coagulation Disorders C0007785; Cerebral Infarction C0007786; Brain Ischemia C0009375; Colonic Neoplasms |
HGMD (count: 82) (view all) | CP035430; Factor V deficiency; Complex rearrangements
CD070466; Factor V deficiency; Small deletions CD067862; Factor V deficiency; Small deletions CD025208; Factor V deficiency; Small deletions CD034338; Factor V deficiency; Small deletions CD982637; Factor V deficiency; Small deletions |
GWASdb (count: 46) (view all) | rs6427194; Venous thromboembolism; vein disease
rs6427194; Venous thrombosis; Null rs6427195; Venous thromboembolism; vein disease rs6427195; Venous thrombosis; Null rs6427196; Venous thromboembolism; vein disease rs6427196; Venous thrombosis; Null |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 35) (view all) | 1047 HAPLSPRTFHPLRSE dbPAF
1053 RTFHPLRSEAYNTFS dbPAF 1056 HPLRSEAYNTFSERR dbPAF 1058 LRSEAYNTFSERRLK dbPAF 1067 SERRLKHSLVLHKSN dbPAF 1148 TSDPSHRSSSPELSE dbPAF |
Glycation (count: 8) (view all) | 105 IKVHFKNKADKPLSI PLMD
121 PQGIRYSKLSEGASY PLMD 1801 LTSSEMKKSHEFHAI PLMD 205 LTEGGTQKTFDKQIV PLMD 2185 FEGNTNTKGHVKNFF PLMD 389 NFSNQIGKHYKKVMY PLMD |
Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | B | Source | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|