| Tag | Content |
|---|---|
| UniProt Accession | NFH_HUMAN; P12036; |
| Entrez ID | 4744 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) |
| Gene Name | NEFH; KIAA0845; NFH |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. |
| Sequence (Fasta) | MMSFGGADAL LGAPFAPLHG GGSLHYALAR KGGAGGTRSA AGSSSGFHSW TRTSVSSVSA 60 SPSRFRGAGA ASSTDSLDTL SNGPEGCMVA VATSRSEKEQ LQALNDRFAG YIDKVRQLEA 120 HNRSLEGEAA ALRQQQAGRS AMGELYEREV REMRGAVLRL GAARGQLRLE QEHLLEDIAH 180 VRQRLDDEAR QREEAEAAAR ALARFAQEAE AARVDLQKKA QALQEECGYL RRHHQEEVGE 240 LLGQIQGSGA AQAQMQAETR DALKCDVTSA LREIRAQLEG HAVQSTLQSE EWFRVRLDRL 300 SEAAKVNTDA MRSAQEEITE YRRQLQARTT ELEALKSTKD SLERQRSELE DRHQADIASY 360 QEAIQQLDAE LRNTKWEMAA QLREYQDLLN VKMALDIEIA AYRKLLEGEE CRIGFGPIPF 420 SLPEGLPKIP SVSTHIKVKS EEKIKVVEKS EKETVIVEEQ TEETQVTEEV TEEEEKEAKE 480 EEGKEEEGGE EEEAEGGEEE TKSPPAEEAA SPEKEAKSPV KEEAKSPAEA KSPEKEEAKS 540 PAEVKSPEKA KSPAKEEAKS PPEAKSPEKE EAKSPAEVKS PEKAKSPAKE EAKSPAEAKS 600 PEKAKSPVKE EAKSPAEAKS PVKEEAKSPA EVKSPEKAKS PTKEEAKSPE KAKSPEKAKS 660 PEKEEAKSPE KAKSPVKAEA KSPEKAKSPV KAEAKSPEKA KSPVKEEAKS PEKAKSPVKE 720 EAKSPEKAKS PVKEEAKTPE KAKSPVKEEA KSPEKAKSPE KAKTLDVKSP EAKTPAKEEA 780 RSPADKFPEK AKSPVKEEVK SPEKAKSPLK EDAKAPEKEI PKKEEVKSPV KEEEKPQEVK 840 VKEPPKKAEE EKAPATPKTE EKKDSKKEEA PKKEAPKPKV EEKKEPAVEK PKESKVEAKK 900 EEAEDKKKVP TPEKEAPAKV EVKEDAKPKE KTEVAKKEPD DAKAKEPSKP AEKKEAAPEK 960 KDTKEEKAKK PEEKPKTEAK AKEDDKTLSK EPSKPKAEKA EKSSSTDQKD SKPPEKATED 1020 KAAKGK 1027 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 3) | MESH:C531617
; Amyotrophic lateral sclerosis 1 OMIM:616924 ; CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2CC MESH:D010523 ; Peripheral Nervous System Diseases |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 53) (view all) | 111 LNDRFAGYIDKVRQL dbPAF
337 TELEALKSTKDSLER dbPAF 385 MAAQLREYQDLLNVK dbPAF 501 AEGGEEETKSPPAEE dbPAF 503 GGEEETKSPPAEEAA dbPAF 511 PPAEEAASPEKEAKS dbPAF |
| Ubiquitination (count: 3) | 264 AETRDALKCDVTSAL PLMD
336 TTELEALKSTKDSLE PLMD 98 VATSRSEKEQLQALN PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |