Tag | Content |
---|---|
UniProt Accession | A4_MOUSE; P12023; |
Entrez ID | 11820 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-A |
Gene Name | App |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane recept(view all) |
Sequence (Fasta) | MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK 60 TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG 120 EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR 180 GVEFVCCPLA EESDSVDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE 240 EADDDEDVED GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVREV CSEQAETGPC 300 RAMISRWYFD VTEGKCVPFF YGGCGGNRNN FDTEEYCMAV CGSVSTQSLL KTTSEPLPQD 360 PDKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA 420 KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL 480 QAVPPRPHHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER 540 MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET 600 KTTVELLPVN GEFSLDDLQP WHPFGVDSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN 660 IKTEEISEVK MDAEFGHDSG FEVRHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL 720 VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN 771 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 25) (view all) | MESH:D019588
; Aging, Premature MESH:D000544 ; Alzheimer Disease MESH:D000647 ; Amnesia MESH:D000686 ; Amyloidosis MESH:C537944 ; Amyloidosis, Cerebroarterial, App-Related MESH:D001008 ; Anxiety Disorders |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 6) | 441 HFQEKVESLEQEAAN dbPAF
679 DAEFGHDSGFEVRHQ dbPAF 728 VMLKKKQYTSIHHGV dbPAF 743 VEVDAAVTPEERHLS dbPAF 757 SKMQQNGYENPTYKF dbPAF 762 NGYENPTYKFFEQMQ dbPAF |
Ubiquitination (count: 3) | 726 TLVMLKKKQYTSIHH PLMD
751 PEERHLSKMQQNGYE PLMD 763 GYENPTYKFFEQMQN PLMD |