P12004

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession PCNA_HUMAN; P12004;
Entrez ID 5111
GenBank Protein ID NM_002592.2; NM_182649.1;
GenBank Nucleotide ID NP_002583.1; NP_872590.1;
Protein Name Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene Name PCNA
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionAuxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Sequence
(Fasta)
MFEARLVQGS ILKKVLEALK DLINEACWDI SSSGVNLQSM DSSHVSLVQL TLRSEGFDTY 60
RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVFEAPNQEK VSDYEMKLMD 120
LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI 180
KLSQTSNVDK EEEAVTIEMN EPVQLTFALR YLNFFTKATP LSSTVTLSMS ADVPLVVEYK 240
IADMGHLKYY LAPKIEDEEG S 262

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationMetabolic syndrome/diseasePY11423201573
[Reference]: Phosphorylation at tyrosine 114 of Proliferating Cell Nuclear Antigen (PCNA) is required for adipogenesis in response to high fat diet
2Tyrosine PhosphorylationProstate cancer/carcinoma/adenocarcinomaPY21121220489
[Reference]: Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth
3Tyrosine PhosphorylationBreast cancer/tumor/carcinomaPY21123542172
[Reference]: The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer
4Tyrosine PhosphorylationTriple-negative breast cancercell linePY21123593472
[Reference]: Tyrosine 211 (Y211) phosphorylation of proliferation cell nuclear antigen (PCNA) coincides with pronounced cancer cell proliferation and correlates with poor survival of breast cancer patients.
5Lysine MethylationLung cancer/carcinomaPK24822556262
[Reference]: SETD8 and PCNA are coexpressed in lung cancer tissues, and lysine 248 methylation of PCNA promotes the proliferation of cancer cells

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 11)
(view all)
MESH:D000230 ; Adenocarcinoma
MESH:C565779 ; Ataxia Telangiectasia Like Disorder
MESH:D001932 ; Brain Neoplasms
MESH:D003110 ; Colonic Neoplasms
MESH:D005923 ; Glomerulosclerosis, Focal Segmental
MESH:D018197 ; Hepatoblastoma
GWASdb
(count: 1)
rs17349; Personality dimensions; personality disorder

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 8)
(view all)
134       GIPEQEYSCVVKMPS     dbPAF
152       ARICRDLSHIGDAVV     dbPAF
161       IGDAVVISCAKDGVK     dbPAF
183       GNGNIKLSQTSNVDK     dbPAF
211       QLTFALRYLNFFTKA     dbPAF
216       LRYLNFFTKATPLSS     dbPAF
Acetylation
(count: 7)
(view all)
13        LVQGSILKKVLEALK     PLMD
164       AVVISCAKDGVKFSA     PLMD
168       SCAKDGVKFSASGEL     PLMD
248       IADMGHLKYYLAPKI     PLMD
254       LKYYLAPKIEDEEGS     PLMD
77        VNLTSMSKILKCAGN     PLMD
Ubiquitination
(count: 15)
(view all)
110       FEAPNQEKVSDYEMK     PLMD
117       KVSDYEMKLMDLDVE     PLMD
13        LVQGSILKKVLEALK     PLMD
138       QEYSCVVKMPSGEFA     PLMD
14        VQGSILKKVLEALKD     PLMD
164       AVVISCAKDGVKFSA     PLMD
Sumoylation
(count: 3)
117       KVSDYEMKLMDLDVE     PLMD
164       AVVISCAKDGVKFSA     PLMD
254       LKYYLAPKIEDEEGS     PLMD
Malonylation
(count: 2)
77        VNLTSMSKILKCAGN     PLMD
80        TSMSKILKCAGNEDI     PLMD
Succinylation
(count: 2)
13        LVQGSILKKVLEALK     PLMD
164       AVVISCAKDGVKFSA     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
A7E2V4P12004BioGRID
B4DIQ8P12004BioGRID
B5MDS6P12004MINT
C9J6D7P12004BioGRID
C9JL81P12004BioGRID
C9JR00P12004BioGRID
C9JRG0P12004BioGRID
E5KP25P12004HPRD
E7ESK3P12004BioGRID
E9PAV3P12004BioGRID
E9PMU0P12004BioGRID
F5H146P12004BioGRID
F5H2Q7P12004BioGRID
F5HB16P12004BioGRID
F8VPD4P12004BioGRID
G3V1P6P12004HPRD
H0Y6W1P12004BioGRID
H0YFK7P12004BioGRID
H7BZR0P12004HPRD
H7C0D8P12004BioGRID
H7C0J3P12004BioGRID
O00268P12004BioGRID
O00327P12004BioGRID
O00748P12004BioGRID
O14776P12004BioGRID
O14802P12004BioGRID
O15218P12004BioGRID
O15304P12004IntAct
O60575P12004BioGRID
O60739P12004IntAct
O60921P12004HPRD
O75293P12004HPRD
O75365P12004IntAct
O75714P12004DIP
O94762P12004DIP
O95067P12004MINT
O95257P12004HPRD; DIP
P00558P12004MINT
P00883P12004MINT
P00918P12004MINT
P01579P12004BioGRID
P01737P12004BioGRID
P02652P12004BioGRID
P02768P12004BioGRID
P04053P12004HPRD
P04075P12004MINT
P04275P12004BioGRID
P04406P12004MINT
P04637P12004BioGRID
P05000P12004BioGRID
P05023P12004BioGRID
P05305P12004BioGRID
P05387P12004BioGRID
P06454P12004HPRD
P06493P12004HPRD
P06733P12004MINT
P06746P12004HPRD
P07355P12004MINT
P07992P12004BioGRID
P08473P12004IntAct
P08729P12004MINT
P08865P12004MINT
P09629P12004BioGRID
P09848P12004BioGRID
P09874P12004HPRD
P0C0S5P12004BioGRID
P0CG12P12004HPRD
P0CG47P12004HPRD
P0CG48P12004MINT
P11142P12004BioGRID
P11168P12004BioGRID
P11171P12004IntAct
P11172P12004BioGRID
P12004P12004HPRD; DIP; IntAct
P12004P12757BioGRID
P12004P12821BioGRID
P12004P12956HPRD
P12004P13010HPRD
P12004P13051HPRD
P12004P13232BioGRID
P12004P13861BioGRID
P12004P14136BioGRID
P12004P14635HPRD
P12004P15428BioGRID
P12004P16144BioGRID
P12004P17252BioGRID
P12004P17480BioGRID
P12004P18136BioGRID
P12004P18505BioGRID
P12004P18545BioGRID
P12004P18583BioGRID
P12004P18669MINT
P12004P18858HPRD
P12004P20248DIP
P12004P20585HPRD
P12004P20674BioGRID
P12004P21709BioGRID
P12004P22674HPRD; DIP
P12004P23508IntAct
P12004P24385HPRD
P12004P24522HPRD; DIP
P12004P24534BioGRID
P12004P24928BioGRID
P12004P24941HPRD; DIP
P12004P26358HPRD
P12004P26583BioGRID
P12004P27694HPRD
P12004P27695HPRD
P12004P28221BioGRID
P12004P28340HPRD; BioGRID; IntAct
P12004P28715HPRD; DIP
P12004P30041MINT
P12004P30281HPRD
P12004P30480IntAct
P12004P30504IntAct
P12004P31268BioGRID
P12004P31269BioGRID
P12004P31689BioGRID
P12004P35249HPRD; DIP
P12004P35250HPRD
P12004P35251HPRD
P12004P35908BioGRID
P12004P36873IntAct
P12004P37198BioGRID
P12004P38936HPRD; DIP; IntAct; MINT
P12004P39748HPRD; DIP; IntAct
P12004P40926MINT
P12004P40937HPRD
P12004P40938HPRD
P12004P42685BioGRID
P12004P42771IntAct
P12004P43246HPRD
P12004P49005HPRD; IntAct
P12004P49023BioGRID
P12004P49918HPRD
P12004P50748BioGRID
P12004P52701HPRD
P12004P53999HPRD
P12004P58753IntAct
P12004P60174MINT
P12004P60709BioGRID
P12004P61006BioGRID
P12004P62070BioGRID
P12004P62136HPRD
P12004P62854BioGRID
P12004P62937MINT
P12004P62988DIP
P12004P67809HPRD
P12004P68032BioGRID
P12004P68104MINT
P12004P78346BioGRID
P12004P78527HPRD
P12004P98160BioGRID
P12004Q00534HPRD
P12004Q00535HPRD
P12004Q02153BioGRID
P12004Q02817BioGRID
P12004Q03252BioGRID
P12004Q03403BioGRID
P12004Q04118BioGRID
P12004Q04206IntAct; MINT
P12004Q05048IntAct
P12004Q07820HPRD
P12004Q07864HPRD
P12004Q08211HPRD
P12004Q08AS3BioGRID
P12004Q09472HPRD
P12004Q13111HPRD; IntAct; MINT
P12004Q13428HPRD
P12004Q13547HPRD
P12004Q14164IntAct
P12004Q14191HPRD
P12004Q14527DIP
P12004Q15019BioGRID
P12004Q15054HPRD; DIP; IntAct; MINT
P12004Q15506BioGRID
P12004Q15714IntAct
P12004Q16658IntAct
P12004Q17RH7BioGRID
P12004Q5QJE6HPRD
P12004Q5VUJ9BioGRID
P12004Q6ZP83BioGRID
P12004Q71DI3BioGRID
P12004Q75N90BioGRID
P12004Q7Z7M0BioGRID
P12004Q8IWY9DIP
P12004Q8TDT2BioGRID
P12004Q8WTR8BioGRID
P12004Q8WV24BioGRID
P12004Q8WVB6HPRD
P12004Q8WZ19HPRD
P12004Q92519BioGRID
P12004Q93074BioGRID
P12004Q96C41DIP
P12004Q96E39BioGRID
P12004Q96G01BioGRID
P12004Q96P26BioGRID
P12004Q96PU4IntAct
P12004Q99457BioGRID
P12004Q99638HPRD
P12004Q99708HPRD
P12004Q99728IntAct
P12004Q99741HPRD
P12004Q9BQG0HPRD
P12004Q9BVC3HPRD
P12004Q9BYP8BioGRID
P12004Q9GZQ8IntAct
P12004Q9H160MINT
P12004Q9H211HPRD; MINT
P12004Q9H2D6BioGRID
P12004Q9H3H5BioGRID
P12004Q9H492IntAct
P12004Q9HCU0BioGRID
P12004Q9HCU8HPRD; IntAct
P12004Q9NP87HPRD
P12004Q9NU63BioGRID
P12004Q9UBZ4HPRD
P12004Q9UET6IntAct
P12004Q9UGP5HPRD
P12004Q9UHD8BioGRID
P12004Q9UIG0HPRD
P12004Q9UK52DIP
P12004Q9UK53HPRD
P12004Q9UNA4HPRD; MINT
P12004Q9Y253HPRD; MINT
P12004Q9Y277BioGRID
P12004Q9Y2R9BioGRID
P12004Q9Y2S7HPRD
P12004Q9Y4K3IntAct
P12004Q9Y6V0BioGRID
P12004Q9Y6Y8HPRD