Tag | Content |
---|---|
UniProt Accession | PCNA_HUMAN; P12004; |
Entrez ID | 5111 |
GenBank Protein ID | NM_002592.2; NM_182649.1; |
GenBank Nucleotide ID | NP_002583.1; NP_872590.1; |
Protein Name | Proliferating cell nuclear antigen (PCNA) (Cyclin) |
Gene Name | PCNA |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. |
Sequence (Fasta) | MFEARLVQGS ILKKVLEALK DLINEACWDI SSSGVNLQSM DSSHVSLVQL TLRSEGFDTY 60 RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVFEAPNQEK VSDYEMKLMD 120 LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI 180 KLSQTSNVDK EEEAVTIEMN EPVQLTFALR YLNFFTKATP LSSTVTLSMS ADVPLVVEYK 240 IADMGHLKYY LAPKIEDEEG S 262 |
|
Database | Annotation |
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CTD (Curated) (count: 11) (view all) | MESH:D000230
; Adenocarcinoma MESH:C565779 ; Ataxia Telangiectasia Like Disorder MESH:D001932 ; Brain Neoplasms MESH:D003110 ; Colonic Neoplasms MESH:D005923 ; Glomerulosclerosis, Focal Segmental MESH:D018197 ; Hepatoblastoma |
GWASdb (count: 1) | rs17349; Personality dimensions; personality disorder |
PTM | Modification Sites |
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Phosphorylation (count: 8) (view all) | 134 GIPEQEYSCVVKMPS dbPAF
152 ARICRDLSHIGDAVV dbPAF 161 IGDAVVISCAKDGVK dbPAF 183 GNGNIKLSQTSNVDK dbPAF 211 QLTFALRYLNFFTKA dbPAF 216 LRYLNFFTKATPLSS dbPAF |
Acetylation (count: 7) (view all) | 13 LVQGSILKKVLEALK PLMD
164 AVVISCAKDGVKFSA PLMD 168 SCAKDGVKFSASGEL PLMD 248 IADMGHLKYYLAPKI PLMD 254 LKYYLAPKIEDEEGS PLMD 77 VNLTSMSKILKCAGN PLMD |
Ubiquitination (count: 15) (view all) | 110 FEAPNQEKVSDYEMK PLMD
117 KVSDYEMKLMDLDVE PLMD 13 LVQGSILKKVLEALK PLMD 138 QEYSCVVKMPSGEFA PLMD 14 VQGSILKKVLEALKD PLMD 164 AVVISCAKDGVKFSA PLMD |
Sumoylation (count: 3) | 117 KVSDYEMKLMDLDVE PLMD
164 AVVISCAKDGVKFSA PLMD 254 LKYYLAPKIEDEEGS PLMD |
Malonylation (count: 2) | 77 VNLTSMSKILKCAGN PLMD
80 TSMSKILKCAGNEDI PLMD |
Succinylation (count: 2) | 13 LVQGSILKKVLEALK PLMD
164 AVVISCAKDGVKFSA PLMD |