| Tag | Content |
|---|---|
| UniProt Accession | CDK4_HUMAN; P11802; |
| Entrez ID | 1019 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3) |
| Gene Name | CDK4 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. |
| Sequence (Fasta) | MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGGGGGLP ISTVREVALL 60 RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHVDQDL RTYLDKAPPP GLPAETIKDL 120 MRQFLRGLDF LHANCIVHRD LKPENILVTS GGTVKLADFG LARIYSYQMA LTPVVVTLWY 180 RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR 240 DVSLPRGAFP PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKDEG 300 NPE 304 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | melanoma familial malignant melanoma |
| CTD (Curated) (count: 10) (view all) | MESH:D001932
; Brain Neoplasms MESH:D020295 ; Brain Stem Neoplasms MESH:D002277 ; Carcinoma MESH:D006528 ; Carcinoma, Hepatocellular MESH:D008080 ; Liposarcoma MESH:D015674 ; Mammary Neoplasms, Animal |
| DisGeNet (Curated) (count: 25) (view all) | C0006118; Brain Neoplasms
C0016689; Freckles C0023827; liposarcoma C0024228; Lymphatic Diseases C0024667; Animal Mammary Neoplasms C0024668; Mammary Neoplasms, Experimental |
| GWASdb (count: 1) | rs2069501; HIV-1 viral setpoint; Human immunodeficiency virus infectious disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 14) (view all) | 102 HVDQDLRTYLDKAPP dbPAF
103 VDQDLRTYLDKAPPP dbPAF 150 PENILVTSGGTVKLA dbPAF 153 ILVTSGGTVKLADFG dbPAF 165 DFGLARIYSYQMALT dbPAF 166 FGLARIYSYQMALTP dbPAF |
| Ubiquitination (count: 8) (view all) | 106 DLRTYLDKAPPPGLP PLMD
118 GLPAETIKDLMRQFL PLMD 142 CIVHRDLKPENILVT PLMD 155 VTSGGTVKLADFGLA PLMD 211 FAEMFRRKPLFCGNS PLMD 22 GAYGTVYKARDPHSG PLMD |
| Sumoylation (count: 1) | 297 LQHSYLHKDEGNPE* PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |