Tag | Content |
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UniProt Accession | RAF1_RAT; P11345; |
Entrez ID | 24703 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) |
Gene Name | Raf1; Raf |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3(view all) |
Sequence (Fasta) | MEHIQGAWKT ISNGFGLKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD SSKTSNTIRV 60 FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLQEHKGKKA RLDWNTDAAS 120 LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV 180 PTMCVDWSNI RQLLLFPNST ASDSGVPAPP SFTMRRMRES VSRMPASSQH RYSTPHAFTF 240 NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL 300 SPTGWSQPKT PVPAQRERAP GSGTQEKNKI RPRGQRDSSY YWEIEASEVM LSTRIGSGSF 360 GTVYKGKWHG DVAVKILKVV DPTPEQLQAF RNEVAVLRKT RHVNILLFMG YMTKDNLAIV 420 TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL 480 TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE 540 LMTGELPYSH INNRDQIIFM VGRGYASPDL SRLYKNCPKA MKRLVADCVK KVKEERPLFP 600 QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF 649 |
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Database | Annotation |
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CTD (Curated) (count: 15) (view all) | MESH:D001943
; Breast Neoplasms MESH:D002311 ; Cardiomyopathy, Dilated OMIM:615916 ; CARDIOMYOPATHY, DILATED, 1NN MESH:D002312 ; Cardiomyopathy, Hypertrophic MESH:D005910 ; Glioma MESH:D006930 ; Hyperalgesia |
PTM | Modification Sites |
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Phosphorylation (count: 18) (view all) | 239 YSTPHAFTFNTSSPS dbPAF
259 SQRQRSTSTPNVHMV dbPAF 26 DAVFDGSSCISPTIV dbPAF 267 TPNVHMVSTTLPVDS dbPAF 289 RSHSESASPSALSSS dbPAF 294 SASPSALSSSPNNLS dbPAF |