Tag | Content |
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UniProt Accession | BCR_HUMAN; P11274; |
Entrez ID | 613 |
GenBank Protein ID | NM_004327.3; NM_021574.2; |
GenBank Nucleotide ID | NP_004318.3; NP_067585.2; |
Protein Name | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) |
Gene Name | BCR; BCR1; D22S11 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity. |
Sequence (Fasta) | MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN QERFRMIYLQ 60 TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA PADGADPPPA EEPEARPDGE 120 GSPGKARPGT ARRPGAAASG ERDDRGPPAS VAALRSNFER IRKGHGQPGA DAEKPFYVNV 180 EFHHERGLVK VNDKEVSDRI SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC 240 GVDGDYEDAE LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ 300 STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS SRVSPSPTTY 360 RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS EATIVGVRKT GQIWPNDGEG 420 AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ DGLPYIDDSP SSSPHLSSKG RGSRDALVSG 480 ALESTKASEL DLEKGLEMRK WVLSGILASE ETYLSHLEAL LLPMKPLKAA ATTSQPVLTS 540 QQIETIFFKV PELYEIHKEF YDGLFPRVQQ WSHQQRVGDL FQKLASQLGV YRAFVDNYGV 600 AMEMAEKCCQ ANAQFAEISE NLRARSNKDA KDPTTKNSLE TLLYKPVDRV TRSTLVLHDL 660 LKHTPASHPD HPLLQDALRI SQNFLSSINE EITPRRQSMT VKKGEHRQLL KDSFMVELVE 720 GARKLRHVFL FTDLLLCTKL KKQSGGKTQQ YDCKWYIPLT DLSFQMVDEL EAVPNIPLVP 780 DEELDALKIK ISQIKNDIQR EKRANKGSKA TERLKKKLSE QESLLLLMSP SMAFRVHSRN 840 GKSYTFLISS DYERAEWREN IREQQKKCFR SFSLTSVELQ MLTNSCVKLQ TVHSIPLTIN 900 KEDDESPGLY GFLNVIVHSA TGFKQSSNLY CTLEVDSFGY FVNKAKTRVY RDTAEPNWNE 960 EFEIELEGSQ TLRILCYEKC YNKTKIPKED GESTDRLMGK GQVQLDPQAL QDRDWQRTVI 1020 AMNGIEVKLS VKFNSREFSL KRMPSRKQTG VFGVKIAVVT KRERSKVPYI VRQCVEEIER 1080 RGMEEVGIYR VSGVATDIQA LKAAFDVNNK DVSVMMSEMD VNAIAGTLKL YFRELPEPLF 1140 TDEFYPNFAE GIALSDPVAK ESCMLNLLLS LPEANLLTFL FLLDHLKRVA EKEAVNKMSL 1200 HNLATVFGPT LLRPSEKESK LPANPSQPIT MTDSWSLEVM SQVQVLLYFL QLEAIPAPDS 1260 KRQSILFSTE V 1272 |
|
Database | Annotation |
---|---|
Cancer Gene Census | CML, ALL, AML |
CTD (Curated) (count: 7) (view all) | MESH:D001752
; Blast Crisis MESH:D015464 ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D009196 ; Myeloproliferative Disorders MESH:D009336 ; Necrosis MESH:D009374 ; Neoplasms, Experimental |
GWASdb (count: 22) (view all) | rs6003555; Narcolepsy; narcolepsy
rs5996498; Multiple complex diseases; Null rs762601; Lung function (forced expiratory volume in 1 second to forced vital capacity ratio); lung disease rs2156921; Oral cancers (chewing tobacco related); squamous cell carcinoma|mouth disease rs2156921; Lung function (forced expiratory volume in 1 second to forced vital capacity ratio); lung disease rs4822375; Lung function (forced expiratory volume in 1 second to forced vital capacity ratio); lung disease |
PTM | Modification Sites |
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Phosphorylation (count: 105) (view all) | 1018 QDRDWQRTVIAMNGI dbPAF
1030 NGIEVKLSVKFNSRE dbPAF 1035 KLSVKFNSREFSLKR dbPAF 1039 KFNSREFSLKRMPSR dbPAF 1049 RMPSRKQTGVFGVKI dbPAF 1069 RERSKVPYIVRQCVE dbPAF |
Acetylation (count: 1) | 747 LKKQSGGKTQQYDCK PLMD |
Ubiquitination (count: 6) | 1066 VTKRERSKVPYIVRQ PLMD
194 GLVKVNDKEVSDRIS PLMD 214 AMQMERKKSQHGAGS PLMD 583 RVGDLFQKLASQLGV PLMD 645 SLETLLYKPVDRVTR PLMD 662 LVLHDLLKHTPASHP PLMD |
Glycation (count: 1) | 1220 RPSEKESKLPANPSQ PLMD |
Malonylation (count: 2) | 1047 LKRMPSRKQTGVFGV PLMD
1066 VTKRERSKVPYIVRQ PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |