P11274

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession BCR_HUMAN; P11274;
Entrez ID 613
GenBank Protein ID NM_004327.3; NM_021574.2;
GenBank Nucleotide ID NP_004318.3; NP_067585.2;
Protein Name Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)
Gene Name BCR; BCR1; D22S11
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionGTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
Sequence
(Fasta)
MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN QERFRMIYLQ 60
TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA PADGADPPPA EEPEARPDGE 120
GSPGKARPGT ARRPGAAASG ERDDRGPPAS VAALRSNFER IRKGHGQPGA DAEKPFYVNV 180
EFHHERGLVK VNDKEVSDRI SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC 240
GVDGDYEDAE LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ 300
STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS SRVSPSPTTY 360
RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS EATIVGVRKT GQIWPNDGEG 420
AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ DGLPYIDDSP SSSPHLSSKG RGSRDALVSG 480
ALESTKASEL DLEKGLEMRK WVLSGILASE ETYLSHLEAL LLPMKPLKAA ATTSQPVLTS 540
QQIETIFFKV PELYEIHKEF YDGLFPRVQQ WSHQQRVGDL FQKLASQLGV YRAFVDNYGV 600
AMEMAEKCCQ ANAQFAEISE NLRARSNKDA KDPTTKNSLE TLLYKPVDRV TRSTLVLHDL 660
LKHTPASHPD HPLLQDALRI SQNFLSSINE EITPRRQSMT VKKGEHRQLL KDSFMVELVE 720
GARKLRHVFL FTDLLLCTKL KKQSGGKTQQ YDCKWYIPLT DLSFQMVDEL EAVPNIPLVP 780
DEELDALKIK ISQIKNDIQR EKRANKGSKA TERLKKKLSE QESLLLLMSP SMAFRVHSRN 840
GKSYTFLISS DYERAEWREN IREQQKKCFR SFSLTSVELQ MLTNSCVKLQ TVHSIPLTIN 900
KEDDESPGLY GFLNVIVHSA TGFKQSSNLY CTLEVDSFGY FVNKAKTRVY RDTAEPNWNE 960
EFEIELEGSQ TLRILCYEKC YNKTKIPKED GESTDRLMGK GQVQLDPQAL QDRDWQRTVI 1020
AMNGIEVKLS VKFNSREFSL KRMPSRKQTG VFGVKIAVVT KRERSKVPYI VRQCVEEIER 1080
RGMEEVGIYR VSGVATDIQA LKAAFDVNNK DVSVMMSEMD VNAIAGTLKL YFRELPEPLF 1140
TDEFYPNFAE GIALSDPVAK ESCMLNLLLS LPEANLLTFL FLLDHLKRVA EKEAVNKMSL 1200
HNLATVFGPT LLRPSEKESK LPANPSQPIT MTDSWSLEVM SQVQVLLYFL QLEAIPAPDS 1260
KRQSILFSTE V 1272

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationChronic myelogenous leukemia/Chronic myeloid leukemiaUY17712124177
[Reference]: Compared to BCR/ABL-expressing Ba/F3 cells, BCR/ABL-Y177F cells exhibit markedly reduced Gab2 tyrosine phosphorylation and association of phosphatidylinositol-3 kinase (PI3K) and Shp2 with Gab2 and BCR/ABL, and decreased PI3K/Akt and Ras/Erk activation, cell proliferation, and spontaneous migration.

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
CML, ALL, AML
CTD (Curated)
(count: 7)
(view all)
MESH:D001752 ; Blast Crisis
MESH:D015464 ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive
MESH:D008106 ; Liver Cirrhosis, Experimental
MESH:D009196 ; Myeloproliferative Disorders
MESH:D009336 ; Necrosis
MESH:D009374 ; Neoplasms, Experimental
GWASdb
(count: 22)
(view all)
rs6003555; Narcolepsy; narcolepsy
rs5996498; Multiple complex diseases; Null
rs762601; Lung function (forced expiratory volume in 1 second to forced vital capacity ratio); lung disease
rs2156921; Oral cancers (chewing tobacco related); squamous cell carcinoma|mouth disease
rs2156921; Lung function (forced expiratory volume in 1 second to forced vital capacity ratio); lung disease
rs4822375; Lung function (forced expiratory volume in 1 second to forced vital capacity ratio); lung disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 105)
(view all)
1018      QDRDWQRTVIAMNGI     dbPAF
1030      NGIEVKLSVKFNSRE     dbPAF
1035      KLSVKFNSREFSLKR     dbPAF
1039      KFNSREFSLKRMPSR     dbPAF
1049      RMPSRKQTGVFGVKI     dbPAF
1069      RERSKVPYIVRQCVE     dbPAF
Acetylation
(count: 1)
747       LKKQSGGKTQQYDCK     PLMD
Ubiquitination
(count: 6)
1066      VTKRERSKVPYIVRQ     PLMD
194       GLVKVNDKEVSDRIS     PLMD
214       AMQMERKKSQHGAGS     PLMD
583       RVGDLFQKLASQLGV     PLMD
645       SLETLLYKPVDRVTR     PLMD
662       LVLHDLLKHTPASHP     PLMD
Glycation
(count: 1)
1220      RPSEKESKLPANPSQ     PLMD
Malonylation
(count: 2)
1047      LKRMPSRKQTGVFGV     PLMD
1066      VTKRERSKVPYIVRQ     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource