P11234

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession RALB_HUMAN; P11234;
Entrez ID 5899
GenBank Protein ID NM_002881.2; XM_005263724.1; XM_005263727.1; XM_005263728.1; XM_005263729.2; XM_017004622.1;
GenBank Nucleotide ID NP_002872.1; XP_005263781.1; XP_005263784.1; XP_005263785.1; XP_005263786.1; XP_016860111.1;
Protein Name Ras-related protein Ral-B
Gene Name RALB
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMultifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).
Sequence
(Fasta)		MAANKSKGQS SLALHKVIMV GSGGVGKSAL TLQFMYDEFV EDYEPTKADS YRKKVVLDGE 60
EVQIDILDTA GQEDYAAIRD NYFRSGEGFL LVFSITEHES FTATAEFREQ ILRVKAEEDK 120
IPLLVVGNKS DLEERRQVPV EEARSKAEEW GVQYVETSAK TRANVDKVFF DLMREIRTKK 180
MSENKDKNGK KSSKNKKSFK ERCCLL 207

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationBladder cancerPS19820940393
[Reference]: Phosphorylation of RalB is important for bladder cancer cell growth and metastasis

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 8)
(view all)		rs4849842; Multiple complex diseases; Null
rs1370379; Alcohol dependence; alcohol dependence
rs3931841; Multiple complex diseases; Null
rs3931840; Alcohol dependence; alcohol dependence
rs3931840; Body mass index; obesity
rs2289172; Multiple complex diseases; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 7)
(view all)		 10        ANKSKGQSSLALHKV     dbPAF
104       EHESFTATAEFREQI     dbPAF
11        NKSKGQSSLALHKVI     dbPAF
198       KSSKNKKSFKERCCL     dbPAF
43        YDEFVEDYEPTKADS     dbPAF
82        YAAIRDNYFRSGEGF     dbPAF
Ubiquitination
(count: 2)		 120       RVKAEEDKIPLLVVG     PLMD
160       QYVETSAKTRANVDK     PLMD