Tag | Content |
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UniProt Accession | RALA_HUMAN; P11233; |
Entrez ID | 5898 |
GenBank Protein ID | NM_005402.3; XM_006715762.2; XM_011515466.1; |
GenBank Nucleotide ID | NP_005393.2; XP_006715825.1; XP_011513768.1; |
Protein Name | Ras-related protein Ral-A |
Gene Name | RALA; RAL |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). |
Sequence (Fasta) | MAANKPKGQN SLALHKVIMV GSGGVGKSAL TLQFMYDEFV EDYEPTKADS YRKKVVLDGE 60 EVQIDILDTA GQEDYAAIRD NYFRSGEGFL CVFSITEMES FAATADFREQ ILRVKEDENV 120 PFLLVGNKSD LEDKRQVSVE EAKNRAEQWN VNYVETSAKT RANVDKVFFD LMREIRARKM 180 EDSKEKNGKK KRKSLAKRIR ERCCIL 207 |
|
Database | Annotation |
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GWASdb (count: 3) | rs13311977; Calcium levels; calcium metabolism disease|atherosclerosis
rs1034771; Body Mass Index; obesity rs10486802; Urinary metabolites; kidney disease |
PTM | Modification Sites |
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Phosphorylation (count: 11) (view all) | 11 NKPKGQNSLALHKVI dbPAF
138 LEDKRQVSVEEAKNR dbPAF 153 AEQWNVNYVETSAKT dbPAF 183 RARKMEDSKEKNGKK dbPAF 194 NGKKKRKSLAKRIRE dbPAF 22 HKVIMVGSGGVGKSA dbPAF |
Ubiquitination (count: 8) (view all) | 128 PFLLVGNKSDLEDKR PLMD
134 NKSDLEDKRQVSVEE PLMD 143 QVSVEEAKNRAEQWN PLMD 159 NYVETSAKTRANVDK PLMD 166 KTRANVDKVFFDLMR PLMD 179 MREIRARKMEDSKEK PLMD |
Glycation (count: 4) | 128 PFLLVGNKSDLEDKR PLMD
143 QVSVEEAKNRAEQWN PLMD 16 QNSLALHKVIMVGSG PLMD 166 KTRANVDKVFFDLMR PLMD |
Malonylation (count: 1) | 16 QNSLALHKVIMVGSG PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |