| Tag | Content |
|---|---|
| UniProt Accession | MTAP2_HUMAN; P11137; |
| Entrez ID | 4133 |
| GenBank Protein ID | NM_001039538.1; NM_002374.3; NM_031845.2; NM_031847.2; XM_017004118.1; XM_017004123.1; XM_017004124.1; XM_017004138.1; XM_017004139.1; XM_017004140.1; |
| GenBank Nucleotide ID | NP_001034627.1; NP_002365.3; NP_114033.2; NP_114035.2; XP_016859607.1; XP_016859612.1; XP_016859613.1; XP_016859627.1; XP_016859628.1; XP_016859629.1; |
| Protein Name | Microtubule-associated protein 2 (MAP-2) |
| Gene Name | MAP2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| Sequence (Fasta) | MADERKDEAK APHWTSAPLT EASAHSHPPE IKDQGGAGEG LVRSANGFPY REDEEGAFGE 60 HGSQGTYSNT KENGINGELT SADRETAEEV SARIVQVVTA EAVAVLKGEQ EKEAQHKDQT 120 AALPLAAEET ANLPPSPPPS PASEQTVTVE EDLLTASKME FHDQQELTPS TAEPSDQKEK 180 ESEKQSKPGE DLKHAALVSQ PETTKTYPDK KDMQGTEEEK APLALFGHTL VASLEDMKQK 240 TEPSLVVPGI DLPKEPPTPK EQKDWFIEMP TEAKKDEWGL VAPISPGPLT PMREKDVFDD 300 IPKWEGKQFD SPMPSPFQGG SFTLPLDVMK NEIVTETSPF APAFLQPDDK KSLQQTSGPA 360 TAKDSFKIEE PHEAKPDKMA EAPPSEAMTL PKDAHIPVVE EHVMGKVLEE EKEAINQETV 420 QQRDTFTPSG QEPILTEKET ELKLEEKTTI SDKEAVPKES KPPKPADEEI GIIQTSTEHT 480 FSEQKDQEPT TDMLKQDSFP VSLEQAVTDS AMTSKTLEKA MTEPSALIEK SSIQELFEMR 540 VDDKDKIEGV GAATSAELDM PFYEDKSGMS KYFETSALKE EATKSIEPGS DYYELSDTRE 600 SVHESIDTMS PMHKNGDKEF QTGKESQPSP PAQEAGYSTL AQSYPSDLPE EPSSPQERMF 660 TIDPKVYGEK RDLHSKNKDD LTLSRSLGLG GRSAIEQRSM SINLPMSCLD SIALGFNFGR 720 GHDLSPLASD ILTNTSGSMD EGDDYLPATT PALEKAPCFP VESKEEEQIE KVKATGEEST 780 QAEISCESPF LAKDFYKNGT VMAPDLPEML DLAGTRSRLA SVSADAEVAR RKSVPSETVV 840 EDSRTGLPPV TDENHVIVKT DSQLEDLGYC VFNKYTVPLP SPVQDSENLS GESGTFYEGT 900 DDKVRRDLAT DLSLIEVKLA AAGRVKDEFS VDKEASAHIS GDKSGLSKEF DQEKKANDRL 960 DTVLEKSEEH ADSKEHAKKT EEAGDEIETF GLGVTYEQAL AKDLSIPTDA SSEKAEKGLS 1020 SVPEIAEVEP SKKVEQGLDF AVQGQLDVKI SDFGQMASGL NIDDRRATEL KLEATQDMTP 1080 SSKAPQEADA FMGVESGHMK EGTKVSETEV KEKVAKPDLV HQEAVDKEES YESSGEHESL 1140 TMESLKADEG KKETSPESSL IQDEIAVKLS VEIPCPPAVS EADLATDERA DVQMEFIQGP 1200 KEESKETPDI SITPSDVAEP LHETIVSEPA EIQSEEEEIE AQGEYDKLLF RSDTLQITDL 1260 GVSGAREEFV ETCPSEHKGV IESVVTIEDD FITVVQTTTD EGESGSHSVR FAALEQPEVE 1320 RRPSPHDEEE FEVEEAAEAQ AEPKDGSPEA PASPEREEVA LSEYKTETYD DYKDETTIDD 1380 SIMDADSLWV DTQDDDRSIM TEQLETIPKE EKAEKEARRS SLEKHRKEKP FKTGRGRIST 1440 PERKVAKKEP STVSRDEVRR KKAVYKKAEL AKKTEVQAHS PSRKFILKPA IKYTRPTHLS 1500 CVKRKTTAAG GESALAPSVF KQAKDKVSDG VTKSPEKRSS LPRPSSILPP RRGVSGDRDE 1560 NSFSLNSSIS SSARRTTRSE PIRRAGKSGT STPTTPGSTA ITPGTPPSYS SRTPGTPGTP 1620 SYPRTPHTPG TPKSAILVPS EKKVAIIRTP PKSPATPKQL RLINQPLPDL KNVKSKIGST 1680 DNIKYQPKGG QVQIVTKKID LSHVTSKCGS LKNIRHRPGG GRVKIESVKL DFKEKAQAKV 1740 GSLDNAHHVP GGGNVKIDSQ KLNFREHAKA RVDHGAEIIT QSPGRSSVAS PRRLSNVSSS 1800 GSINLLESPQ LATLAEDVTA ALAKQGL 1828 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | MESH:D000022
; Abortion, Spontaneous MESH:D001171 ; Arthritis, Juvenile |
| DisGeNet (Curated) (count: 7) (view all) | C0000786; Spontaneous abortion
C0005586; Bipolar Disorder C0036341; Schizophrenia C0041696; Unipolar Depression C0525045; Mood Disorders C1269683; Major Depressive Disorder |
| GWASdb (count: 16) (view all) | rs6435527; IgE levels; selective IgE deficiency disease
rs16842900; Multiple complex diseases; Null rs17236116; Body mass index; obesity rs16842904; Multiple complex diseases; Null rs10737940; IgE levels; selective IgE deficiency disease rs7601095; IgE levels; selective IgE deficiency disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 113) (view all) | 1005 QALAKDLSIPTDASS dbPAF
1008 AKDLSIPTDASSEKA dbPAF 1021 KAEKGLSSVPEIAEV dbPAF 1031 EIAEVEPSKKVEQGL dbPAF 1106 MKEGTKVSETEVKEK dbPAF 1108 EGTKVSETEVKEKVA dbPAF |
| Glycation (count: 2) | 220 MQGTEEEKAPLALFG PLMD
238 VASLEDMKQKTEPSL PLMD |