Tag | Content |
---|---|
UniProt Accession | TAU_MOUSE; P10637; |
Entrez ID | 17762 |
GenBank Protein ID | NM_001038609.2; NM_001285454.1; NM_001285455.1; NM_001285456.1; NM_010838.4; |
GenBank Nucleotide ID | NP_001033698.1; NP_001272383.1; NP_001272384.1; NP_001272385.1; NP_034968.3; |
Protein Name | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) |
Gene Name | Mapt; Mtapt; Tau |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
Sequence (Fasta) | MADPRQEFDT MEDHAGDYTL LQDQEGDMDH GLKESPPQPP ADDGAEEPGS ETSDAKSTPT 60 AEDVTAPLVD ERAPDKQAAA QPHTEIPEGI TAEEAGIGDT PNQEDQAAGH VTQGRREGQA 120 PDLGTSDWTR QQVSSMSGAP LLPQGLREAT CQPSGTRPED IEKSHPASEL LRRGPPQKEG 180 WGQDRLGSEE EVDEDLTVDE SSQDSPPSQA SLTPGRAAPQ AGSGSVCGET ASVPGLPTEG 240 SVPLPADFFS KVSAETQASQ PEGPGTGPME EGHEAAPEFT FHVEIKASTP KEQDLEGATV 300 VGVPGEEQKA QTQGPSVGKG TKEASLQEPP GKQPAAGLPG RPVSRVPQLK ARVASKDRTG 360 NDEKKAKTST PSCAKAPSHR PCLSPTRPTL GSSDPLIKPS SPAVSPEPAT SPKHVSSVTP 420 RNGSPGTKQM KLKGADGKTG AKIATPRGAA SPAQKGTSNA TRIPAKTTPS PKTPPGSGEP 480 PKSGERSGYS SPGSPGTPGS RSRTPSLPTP PTREPKKVAV VRTPPKSPSA SKSRLQTAPV 540 PMPDLKNVRS KIGSTENLKH QPGGGKVQII NKKLDLSNVQ SKCGSKDNIK HVPGGGSVQI 600 VYKPVDLSKV TSKCGSLGNI HHKPGGGQVE VKSEKLDFKD RVQSKIGSLD NITHVPGGGN 660 KKIETHKLTF RENAKAKTDH GAEIVYKSPV VSGDTSPRHL SNVSSTGSID MVDSPQLATL 720 ADEVSASLAK QGL 734 |
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Database | Annotation |
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CTD (Curated) (count: 19) (view all) | MESH:D000544
; Alzheimer Disease MESH:D003072 ; Cognition Disorders MESH:D003704 ; Dementia MESH:D004195 ; Disease Models, Animal MESH:D057180 ; Frontotemporal Dementia MESH:D007859 ; Learning Disorders |
PTM | Modification Sites |
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Phosphorylation (count: 58) (view all) | 100 EEAGIGDTPNQEDQA dbPAF
188 WGQDRLGSEEEVDED dbPAF 205 VDESSQDSPPSQASL dbPAF 208 SSQDSPPSQASLTPG dbPAF 213 PPSQASLTPGRAAPQ dbPAF 288 FHVEIKASTPKEQDL dbPAF |
Ubiquitination (count: 4) | 546 PVPMPDLKNVRSKIG PLMD
573 KVQIINKKLDLSNVQ PLMD 582 DLSNVQSKCGSKDNI PLMD 603 GSVQIVYKPVDLSKV PLMD |
Methylation (count: 1) | 551 DLKNVRSKIGSTENL PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |