P10619

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession PPGB_HUMAN; P10619;
Entrez ID 5476
GenBank Protein ID NM_000308.3; NM_001127695.2; NM_001167594.2;
GenBank Nucleotide ID NP_000299.2; NP_001121167.1; NP_001161066.1;
Protein Name Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal prot
Gene Name CTSA; PPGB
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionProtective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
Sequence
(Fasta)		MIRAAPPPLF LLLLLLLLLV SWASRGEAAP DQDEIQRLPG LAKQPSFRQY SGYLKGSGSK 60
HLHYWFVESQ KDPENSPVVL WLNGGPGCSS LDGLLTEHGP FLVQPDGVTL EYNPYSWNLI 120
ANVLYLESPA GVGFSYSDDK FYATNDTEVA QSNFEALQDF FRLFPEYKNN KLFLTGESYA 180
GIYIPTLAVL VMQDPSMNLQ GLAVGNGLSS YEQNDNSLVY FAYYHGLLGN RLWSSLQTHC 240
CSQNKCNFYD NKDLECVTNL QEVARIVGNS GLNIYNLYAP CAGGVPSHFR YEKDTVVVQD 300
LGNIFTRLPL KRMWHQALLR SGDKVRMDPP CTNTTAASTY LNNPYVRKAL NIPEQLPQWD 360
MCNFLVNLQY RRLYRSMNSQ YLKLLSSQKY QILLYNGDVD MACNFMGDEW FVDSLNQKME 420
VQRRPWLVKY GDSGEQIAGF VKEFSHIAFL TIKGAGHMVP TDKPLAAFTM FSRFLNKQPY 480
481

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1GlycosylationGalactosialidosisCT4068968752
[Reference]: The latter include a single base deletion and a novel amino acid change (Met378Thr), which generates an additional glycosylation site.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)		MESH:C536411 ; Neuraminidase deficiency with beta-galactosidase deficiency
HGMD
(count: 21)
(view all)		CD982897; Galactosialidosis; Small deletions
CD962128; Galactosialidosis; Small deletions
CD043199; Galactosialidosis; Small deletions
CP931382; Galactosialidosis; Small indels
CI033880; Galactosialidosis; Small insertions
CM931195; Galactosialidosis; Missense/nonsense
GWASdb
(count: 1)		rs4608591; Type 2 diabetes; type 2 diabetes mellitus

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 4)		 295       HFRYEKDTVVVQDLG     dbPAF
430       RRPWLVKYGDSGEQI     dbPAF
469       DKPLAAFTMFSRFLN     dbPAF
472       LAAFTMFSRFLNKQP     dbPAF
Ubiquitination
(count: 5)		 252       KCNFYDNKDLECVTN     PLMD
293       PSHFRYEKDTVVVQD     PLMD
348       LNNPYVRKALNIPEQ     PLMD
429       QRRPWLVKYGDSGEQ     PLMD
477       MFSRFLNKQPY****     PLMD
Methylation
(count: 1)		 55        RQYSGYLKGSGSKHL     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource