| Tag | Content |
|---|---|
| UniProt Accession | H14_HUMAN; P10412; |
| Entrez ID | 3008 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Histone H1.4 (Histone H1b) (Histone H1s-4) |
| Gene Name | HIST1H1E; H1F4 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). |
| Sequence (Fasta) | MSETAPAAPA APAPAEKTPV KKKARKSAGA AKRKASGPPV SELITKAVAA SKERSGVSLA 60 ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKA 120 KKAGAAKAKK PAGAAKKPKK ATGAATPKKS AKKTPKKAKK PAAAAGAKKA KSPKKAKAAK 180 PKKAPKSPAK AKAVKPKAAK PKTAKPKAAK PKKAAAKKK |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D003528 ; Carcinoma, Adenoid Cystic |
| DisGeNet (Curated) (count: 2) | C0010606; Adenoid Cystic Carcinoma
C0036341; Schizophrenia |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 25) (view all) | 102 QTKGTGASGSFKLNK dbPAF
104 KGTGASGSFKLNKKA dbPAF 113 KLNKKAASGEAKPKA dbPAF 142 AKKPKKATGAATPKK dbPAF 146 KKATGAATPKKSAKK dbPAF 150 GAATPKKSAKKTPKK dbPAF |
| Acetylation (count: 14) (view all) | 106 TGASGSFKLNKKAAS PLMD
168 PAAAAGAKKAKSPKK PLMD 17 AAPAPAEKTPVKKKA PLMD 21 PAEKTPVKKKARKSA PLMD 26 PVKKKARKSAGAAKR PLMD 34 SAGAAKRKASGPPVS PLMD |
| Ubiquitination (count: 17) (view all) | 106 TGASGSFKLNKKAAS PLMD
110 GSFKLNKKAASGEAK PLMD 140 GAAKKPKKATGAATP PLMD 148 ATGAATPKKSAKKTP PLMD 160 KTPKKAKKPAAAAGA PLMD 17 AAPAPAEKTPVKKKA PLMD |
| Sumoylation (count: 2) | 17 AAPAPAEKTPVKKKA PLMD
64 VSLAALKKALAAAGY PLMD |
| Crotonylation (count: 4) | 64 VSLAALKKALAAAGY PLMD
85 SRIKLGLKSLVSKGT PLMD 90 GLKSLVSKGTLVQTK PLMD 97 KGTLVQTKGTGASGS PLMD |
| Glycation (count: 2) | 157 SAKKTPKKAKKPAAA PLMD
46 PVSELITKAVAASKE PLMD |
| Malonylation (count: 9) (view all) | 106 TGASGSFKLNKKAAS PLMD
34 SAGAAKRKASGPPVS PLMD 46 PVSELITKAVAASKE PLMD 63 GVSLAALKKALAAAG PLMD 64 VSLAALKKALAAAGY PLMD 75 AAGYDVEKNNSRIKL PLMD |
| Methylation (count: 13) (view all) | 106 TGASGSFKLNKKAAS PLMD
119 ASGEAKPKAKKAGAA PLMD 121 GEAKPKAKKAGAAKA PLMD 129 KAGAAKAKKPAGAAK PLMD 148 ATGAATPKKSAKKTP PLMD 159 KKTPKKAKKPAAAAG PLMD |
| Succinylation (count: 5) | 106 TGASGSFKLNKKAAS PLMD
63 GVSLAALKKALAAAG PLMD 85 SRIKLGLKSLVSKGT PLMD 90 GLKSLVSKGTLVQTK PLMD 97 KGTLVQTKGTGASGS PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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