Tag | Content |
---|---|
UniProt Accession | ANDR_HUMAN; P10275; |
Entrez ID | 367 |
GenBank Protein ID | NM_000044.4; NM_001011645.3; NM_001348061.1; NM_001348063.1; NM_001348064.1; |
GenBank Nucleotide ID | NP_000035.2; NP_001011645.1; NP_001334990.1; NP_001334992.1; NP_001334993.1; |
Protein Name | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) |
Gene Name | AR; DHTR; NR3C4 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.;Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. |
Sequence (Fasta) | MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP GASLLLLQQQ 60 QQQQQQQQQQ QQQQQQQQQQ ETSPRQQQQQ QGEDGSPQAH RRGPTGYLVL DEEQQPSQPQ 120 SALECHPERG CVPEPGAAVA ASKGLPQQLP APPDEDDSAA PSTLSLLGPT FPGLSSCSAD 180 LKDILSEAST MQLLQQQQQE AVSEGSSSGR AREASGAPTS SKDNYLGGTS TISDNAKELC 240 KAVSVSMGLG VEALEHLSPG EQLRGDCMYA PLLGVPPAVR PTPCAPLAEC KGSLLDDSAG 300 KSTEDTAEYS PFKGGYTKGL EGESLGCSGS AAAGSSGTLE LPSTLSLYKS GALDEAAAYQ 360 SRDYYNFPLA LAGPPPPPPP PHPHARIKLE NPLDYGSAWA AAAAQCRYGD LASLHGAGAA 420 GPGSGSPSAA ASSSWHTLFT AEEGQLYGPC GGGGGGGGGG GGGGGGGGGG GGGEAGAVAP 480 YGYTRPPQGL AGQESDFTAP DVWYPGGMVS RVPYPSPTCV KSEMGPWMDS YSGPYGDMRL 540 ETARDHVLPI DYYFPPQKTC LICGDEASGC HYGALTCGSC KVFFKRAAEG KQKYLCASRN 600 DCTIDKFRRK NCPSCRLRKC YEAGMTLGAR KLKKLGNLKL QEEGEASSTT SPTEETTQKL 660 TVSHIEGYEC QPIFLNVLEA IEPGVVCAGH DNNQPDSFAA LLSSLNELGE RQLVHVVKWA 720 KALPGFRNLH VDDQMAVIQY SWMGLMVFAM GWRSFTNVNS RMLYFAPDLV FNEYRMHKSR 780 MYSQCVRMRH LSQEFGWLQI TPQEFLCMKA LLLFSIIPVD GLKNQKFFDE LRMNYIKELD 840 RIIACKRKNP TSCSRRFYQL TKLLDSVQPI ARELHQFTFD LLIKSHMVSV DFPEMMAEII 900 SVQVPKILSG KVKPIYFHTQ 921 |
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Database | Annotation |
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Cancer Gene Census | prostate |
CTD (Curated) (count: 20) (view all) | MESH:D000505
; Alopecia MESH:D013734 ; Androgen-Insensitivity Syndrome MESH:D001254 ; Astrocytoma MESH:D001321 ; Autistic Disorder MESH:D001943 ; Breast Neoplasms MESH:D018567 ; Breast Neoplasms, Male |
DisGeNet (Curated) (count: 90) (view all) | C0001973; Alcoholic Intoxication, Chronic
C0002170; Alopecia C0004114; Astrocytoma C0004352; Autistic Disorder C0004509; Azoospermia C0010417; Cryptorchidism |
HGMD (count: 391) (view all) | CX910583; Spino-bulbar muscular atrophy (Kennedy disease); Repeat variations
CE994034; Androgen insensitivity syndrome; Repeat variations CE972908; Prostate cancer, increased risk, association; Repeat variations CE972909; Prostate cancer, increased risk, association; Repeat variations HD030005; Androgen insensitivity syndrome; Small deletions CD920831; Androgen insensitivity syndrome; Small deletions |
GWASdb (count: 17) (view all) | rs12396249; Vascular dementia; vascular dementia
rs12396249; Male-pattern baldness; alopecia rs1204038; Male-pattern baldness; alopecia rs2255702; Male-pattern baldness; alopecia rs5918757; Male-pattern baldness; alopecia rs5919393; Vascular dementia; vascular dementia |
PTM | Modification Sites |
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Phosphorylation (count: 36) (view all) | 119 QQPSQPQSALECHPE dbPAF
16 RVYPRPPSKTYRGAF dbPAF 206 AVSEGSSSGRAREAS dbPAF 213 SGRAREASGAPTSSK dbPAF 217 REASGAPTSSKDNYL dbPAF 223 PTSSKDNYLGGTSTI dbPAF |
Acetylation (count: 3) | 631 GMTLGARKLKKLGNL PLMD
633 TLGARKLKKLGNLKL PLMD 634 LGARKLKKLGNLKLQ PLMD |
Ubiquitination (count: 2) | 846 LDRIIACKRKNPTSC PLMD
848 RIIACKRKNPTSCSR PLMD |
Sumoylation (count: 2) | 388 PHPHARIKLENPLDY PLMD
521 YPSPTCVKSEMGPWM PLMD |
Methylation (count: 2) | 631 GMTLGARKLKKLGNL PLMD
633 TLGARKLKKLGNLKL PLMD |