| Tag | Content |
|---|---|
| UniProt Accession | CALM1_HUMAN; P0DP23; |
| Entrez ID | 801 |
| GenBank Protein ID | NM_001329922.1; NM_001743.5; NM_005184.3; NM_006888.4; |
| GenBank Nucleotide ID | NP_001316851.1; NP_001734.1; NP_005175.2; NP_008819.1; |
| Protein Name | Calmodulin-1 |
| Gene Name | CALM1; CALM; CAM; CAM1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). |
| Sequence (Fasta) | MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG 60 NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE 120 EVDEMIREAD IDGDGQVNYE EFVQMMTAK |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 7) (view all) | MESH:D000544
; Alzheimer Disease MESH:D019970 ; Cocaine-Related Disorders OMIM:616247 ; LONG QT SYNDROME 14 MESH:D002189 ; Marijuana Abuse MESH:D010623 ; Phencyclidine Abuse MESH:C536334 ; Polymorphic catecholergic ventricular tachycardia |
| GWASdb (count: 2) | rs2268433; Telomere length; Null
rs3213718; Stroke (pediatric); cerebrovascular disease |
| PTM | Modification Sites |
|---|---|