Tag | Content |
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UniProt Accession | HS71A_HUMAN; P0DMV8; |
Entrez ID | 3303 |
GenBank Protein ID | NM_005345.5; NM_005346.4; |
GenBank Nucleotide ID | NP_005336.3; NP_005337.2; |
Protein Name | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) |
Gene Name | HSPA1A; HSP72; HSPA1; HSX70 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydro(view all) |
Sequence (Fasta) | MAKAAAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA 60 LNPQNTVFDA KRLIGRKFGD PVVQSDMKHW PFQVINDGDK PKVQVSYKGE TKAFYPEEIS 120 SMVLTKMKEI AEAYLGYPVT NAVITVPAYF NDSQRQATKD AGVIAGLNVL RIINEPTAAA 180 IAYGLDRTGK GERNVLIFDL GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVNH 240 FVEEFKRKHK KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA 300 RFEELCSDLF RSTLEPVEKA LRDAKLDKAQ IHDLVLVGGS TRIPKVQKLL QDFFNGRDLN 360 KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS LGLETAGGVM TALIKRNSTI 420 PTKQTQIFTT YSDNQPGVLI QVYEGERAMT KDNNLLGRFE LSGIPPAPRG VPQIEVTFDI 480 DANGILNVTA TDKSTGKANK ITITNDKGRL SKEEIERMVQ EAEKYKAEDE VQRERVSAKN 540 ALESYAFNMK SAVEDEGLKG KISEADKKKV LDKCQEVISW LDANTLAEKD EFEHKRKELE 600 QVCNPIISGL YQGAGGPGPG GFGAQGPKGG SGSGPTIEEV D 642 |
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Database | Annotation |
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CTD (Curated) (count: 12) (view all) | MESH:D058186
; Acute Kidney Injury MESH:D001930 ; Brain Injuries MESH:D021441 ; Carcinoma, Pancreatic Ductal MESH:D004342 ; Drug Hypersensitivity MESH:D018882 ; Heat Stress Disorders MESH:D008107 ; Liver Diseases |
DisGeNet (Curated) (count: 16) (view all) | C0013182; Drug Allergy
C0023895; Liver diseases C0024517; Single major depressive episode C0025202; melanoma C0027627; Neoplasm Metastasis C0030567; Parkinson Disease |
GWASdb (count: 2) | rs1043620; Drug response to Carbamazepine; Null
rs506770; Drug response to Carbamazepine; Null |
PTM | Modification Sites |
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Phosphorylation (count: 49) (view all) | 106 DKPKVQVSYKGETKA dbPAF
107 KPKVQVSYKGETKAF dbPAF 115 KGETKAFYPEEISSM dbPAF 120 AFYPEEISSMVLTKM dbPAF 121 FYPEEISSMVLTKMK dbPAF 125 EISSMVLTKMKEIAE dbPAF |
Acetylation (count: 27) (view all) | 100 QVINDGDKPKVQVSY PLMD
108 PKVQVSYKGETKAFY PLMD 112 VSYKGETKAFYPEEI PLMD 126 ISSMVLTKMKEIAEA PLMD 128 SMVLTKMKEIAEAYL PLMD 246 NHFVEEFKRKHKKDI PLMD |
Ubiquitination (count: 41) (view all) | 100 QVINDGDKPKVQVSY PLMD
102 INDGDKPKVQVSYKG PLMD 108 PKVQVSYKGETKAFY PLMD 112 VSYKGETKAFYPEEI PLMD 126 ISSMVLTKMKEIAEA PLMD 128 SMVLTKMKEIAEAYL PLMD |
Sumoylation (count: 5) | 108 PKVQVSYKGETKAFY PLMD
112 VSYKGETKAFYPEEI PLMD 384 AAILMGDKSENVQDL PLMD 507 KITITNDKGRLSKEE PLMD 71 QNTVFDAKRLIGRKF PLMD |
Malonylation (count: 4) | 246 NHFVEEFKRKHKKDI PLMD
500 KSTGKANKITITNDK PLMD 524 RMVQEAEKYKAEDEV PLMD 56 RLIGDAAKNQVALNP PLMD |
Methylation (count: 3) | 561 EDEGLKGKISEADKK PLMD
567 GKISEADKKKVLDKC PLMD 568 KISEADKKKVLDKCQ PLMD |
Phosphoglycerylation (count: 1) | 597 DEFEHKRKELEQVCN PLMD |
Succinylation (count: 4) | 108 PKVQVSYKGETKAFY PLMD
246 NHFVEEFKRKHKKDI PLMD 56 RLIGDAAKNQVALNP PLMD 71 QNTVFDAKRLIGRKF PLMD |