P0C0S8

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession H2A1_HUMAN; P0C0S8;
Entrez ID 8969
GenBank Protein ID NM_003509.2; NM_003510.2; NM_003511.2; NM_003514.2; NM_021064.4;
GenBank Nucleotide ID NP_003500.1; NP_003501.1; NP_003502.1; NP_003505.1; NP_066408.1;
Protein Name Histone H2A type 1 (H2A.1) (Histone H2A/ptl)
Gene Name HIST1H2AG; H2AFP;; HIST1H2AI; H2AFC;; HIST1H2AK; H2AFD;; HIST1H2AL; H2AFI;; HIST1H2AM; H2AFN
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence
(Fasta)		MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT 60
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK 120
TESHHKAKGK 131

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1UbiquitinationColon cancer/carcinomaP22170051
[Reference]: We also found that Bmi1 regulates histone ubiquitination and is required for colon cancer proliferation in vitro and in vivo
2UbiquitinationCancersPK11923238014
[Reference]: CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis


※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 4)		 102       NKLLGKVTIAQGGVL     dbPAF
121       AVLLPKKTESHHKAK     dbPAF
2         ******MSGRGKQGG     dbPAF
40        RLLRKGNYAERVGAG     dbPAF
Acetylation
(count: 1)		 96        RNDEELNKLLGKVTI     PLMD
Ubiquitination
(count: 3)		 100       ELNKLLGKVTIAQGG     PLMD
37        RVHRLLRKGNYAERV     PLMD
96        RNDEELNKLLGKVTI     PLMD
Sumoylation
(count: 1)		 119       IQAVLLPKKTESHHK     PLMD
Crotonylation
(count: 4)		 119       IQAVLLPKKTESHHK     PLMD
120       QAVLLPKKTESHHKA     PLMD
126       KKTESHHKAKGK***     PLMD
37        RVHRLLRKGNYAERV     PLMD
Malonylation
(count: 1)		 96        RNDEELNKLLGKVTI     PLMD
Methylation
(count: 1)		 100       ELNKLLGKVTIAQGG     PLMD
Succinylation
(count: 1)		 96        RNDEELNKLLGKVTI     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource