P09951

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession SYN1_RAT; P09951;
Entrez ID 24949
GenBank Protein ID NM_001110782.2; NM_019133.2;
GenBank Nucleotide ID NP_001104252.1; NP_062006.1;
Protein Name Synapsin-1 (Synapsin I)
Gene Name Syn1
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionNeuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release.
Sequence
(Fasta)
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPSAASP GATPGSAAAS AERASTAAPV 60
ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG GGSGGAGRGG AAARVLLVID 120
EPHTDWAKYF KGKKIHGEID IKVEQAEFSD LNLVAHANGG FSVDMEVLRN GVKVVRSLKP 180
DFVLIRQHAF SMARNGDYRS LVIGLQYAGI PSVNSLHSVY NFCDKPWVFA QMVRLHKKLG 240
TEEFPLIDQT FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT 300
YATAEPFIDA KYDVRVQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS DRYKLWVDTC 360
SEIFGGLDIC AVEALHGKDG RDHIIEVVGS SMPLIGDHQD EDKQLIVELV VNKMTQALPR 420
QRDASPGRGS HSQTPSPGAL PLGRQTSQQP AGPPAQQRPP PQGGPPQPGP GPQRQGPPLQ 480
QRPPPQGQQH LSGLGPPAGS PLPQRLPSPT AAPQQSASQA TPMTQGQGRQ SRPVAGGPGA 540
PPAARPPASP SPQRQAGPPQ ATRQASISGP APPKVSGASP GGQQRQGPPQ KPPGPAGPIR 600
QASQAGPGPR TGPPTTQQPR PSGPGPAGRP TKPQLAQKPS QDVPPPIIAA AGGPPHPQLN 660
KSQSLTNAFN LPEPAPPRPS LSQDEVKAET IRSLRKSFAS LFSD 705

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationDiabetes mellitusUS60323490331
[Reference]: Unexpectedly, we found a significant increase in the phosphorylation of synapsin I (Ser 603) and GluR1 (Ser 831) in the same experiment.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)
MESH:C564505 ; Epilepsy, X-Linked, with Variable Learning Disabilities and Behavior Disorders

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 28)
(view all)
129       PHTDWAKYFKGKKIH     dbPAF
301       VVALTKTYATAEPFI     dbPAF
312       EPFIDAKYDVRVQKI     dbPAF
332       AYMRTSVSGNWKTNT     dbPAF
341       NWKTNTGSAMLEQIA     dbPAF
39        PPPPSAASPGATPGS     dbPAF
Acetylation
(count: 4)
179       VKVVRSLKPDFVLIR     PLMD
238       QMVRLHKKLGTEEFP     PLMD
311       AEPFIDAKYDVRVQK     PLMD
696       ETIRSLRKSFASLFS     PLMD
Ubiquitination
(count: 2)
238       QMVRLHKKLGTEEFP     PLMD
311       AEPFIDAKYDVRVQK     PLMD