P09917

※ Protein Information

Tag	Content
UniProt Accession	LOX5_HUMAN; P09917;
Entrez ID	240
GenBank Protein ID	NM_000698.4; NM_001256153.2; NM_001256154.2; NM_001320861.1;
GenBank Nucleotide ID	NP_000689.1; NP_001243082.1; NP_001243083.1; NP_001307790.1;
Protein Name	Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase) (EC 1.13.11.34)
Gene Name	ALOX5; LOG5
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. Functional Description Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Sequence (Fasta)	MPSYTVTVAT GSQWFAGTDD YIYLSLVGSA GCSEKHLLDK PFYNDFERGA VDSYDVTVDE 60 ELGEIQLVRI EKRKYWLNDD WYLKYITLKT PHGDYIEFPC YRWITGDVEV VLRDGRAKLA 120 RDDQIHILKQ HRRKELETRQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL 180 NYSKAMENLF INRFMHMFQS SWNDFADFEK IFVKISNTIS ERVMNHWQED LMFGYQFLNG 240 CNPVLIRRCT ELPEKLPVTT EMVECSLERQ LSLEQEVQQG NIFIVDFELL DGIDANKTDP 300 CTLQFLAAPI CLLYKNLANK IVPIAIQLNQ IPGDENPIFL PSDAKYDWLL AKIWVRSSDF 360 HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPIFKLLVAH VRFTIAINTK AREQLICECG 420 LFDKANATGG GGHVQMVQRA MKDLTYASLC FPEAIKARGM ESKEDIPYYF YRDDGLLVWE 480 AIRTFTAEVV DIYYEGDQVV EEDPELQDFV NDVYVYGMRG RKSSGFPKSV KSREQLSEYL 540 TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW 600 HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMARFRK NLEAIVSVIA ERNKKKQLPY 660 YYLSPDRIPN SVAI 675 Fasta Sequence >P09917\|ALOX5; LOG5\|Homo sapiens (Human) MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI

※ PTM-Disease Association

Num	PTM	Disease	Type	PTM Site	PMID
1	Serine Phosphorylation	B-cell lymphoma	U	S524	26210919
1	[Reference]: Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion.
2	Serine Phosphorylation	Chronic lymphocytic leukemia	U	S524	26210919
2	[Reference]: Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 20) (view all)	MESH:D000236 ; Adenoma MESH:D001172 ; Arthritis, Rheumatoid MESH:D001249 ; Asthma MESH:D050197 ; Atherosclerosis MESH:D003092 ; Colitis MESH:D003110 ; Colonic Neoplasms MESH:D003111 ; Colonic Polyps MESH:D003875 ; Drug Eruptions MESH:D019446 ; Endotoxemia MESH:D005596 ; Fractures, Closed MESH:D006930 ; Hyperalgesia MESH:D006976 ; Hypertension, Pulmonary MESH:D020244 ; Infarction, Middle Cerebral Artery MESH:D015464 ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive MESH:D009102 ; Multiple Organ Failure MESH:D009361 ; Neoplasm Invasiveness MESH:D009362 ; Neoplasm Metastasis MESH:D015427 ; Reperfusion Injury MESH:D013274 ; Stomach Neoplasms MESH:D014581 ; Urticaria
DisGeNet (Curated) (count: 19) (view all)	C0001430; Adenoma C0003873; Rheumatoid Arthritis C0004096; Asthma C0004153; Atherosclerosis C0009319; Colitis C0009375; Colonic Neoplasms C0009376; Colonic Polyps C0011609; Drug Eruptions C0020429; Hyperalgesia C0020542; Pulmonary Hypertension C0023473; Myeloid Leukemia, Chronic C0026766; Multiple Organ Failure C0027626; Neoplasm Invasiveness C0027627; Neoplasm Metastasis C0035126; Reperfusion Injury C0038356; Stomach Neoplasms C0042109; Urticaria C0376618; Endotoxemia C0740392; Infarction, Middle Cerebral Artery
GWASdb (count: 7) (view all)	rs7919239; Personality dimensions; personality disorder rs2115819; Drug response to Montelukast; Null rs7090328; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension rs3740107; Coronary heart disease; coronary artery disease rs3780909; Coronary heart disease; coronary artery disease rs1059696; Rheumatoid arthritis; rheumatoid arthritis rs2288619; Red blood cell traits; hematopoietic system disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 24) (view all)	101 DYIEFPCYRWITGDV dbPAF 105 FPCYRWITGDVEVVL dbPAF 182 GVDFVLNYSKAMENL dbPAF 183 VDFVLNYSKAMENLF dbPAF 21 WFAGTDDYIYLSLVG dbPAF 23 AGTDDYIYLSLVGSA dbPAF 250 PVLIRRCTELPEKLP dbPAF 259 LPEKLPVTTEMVECS dbPAF 260 PEKLPVTTEMVECSL dbPAF 266 TTEMVECSLERQLSL dbPAF 272 CSLERQLSLEQEVQQ dbPAF 43 HLLDKPFYNDFERGA dbPAF 445 QRAMKDLTYASLCFP dbPAF 446 RAMKDLTYASLCFPE dbPAF 448 MKDLTYASLCFPEAI dbPAF 486 WEAIRTFTAEVVDIY dbPAF 524 GMRGRKSSGFPKSVK dbPAF 532 GFPKSVKSREQLSEY dbPAF 54 ERGAVDSYDVTVDEE dbPAF 664 QLPYYYLSPDRIPNS dbPAF 671 SPDRIPNSVAI**** dbPAF 75 VRIEKRKYWLNDDWY dbPAF 87 DWYLKYITLKTPHGD dbPAF 95 LKTPHGDYIEFPCYR dbPAF

PTM

Modification Sites

Phosphorylation
(count: 24)
(view all)

101       DYIEFPCYRWITGDV     dbPAF
105       FPCYRWITGDVEVVL     dbPAF
182       GVDFVLNYSKAMENL     dbPAF
183       VDFVLNYSKAMENLF     dbPAF
21        WFAGTDDYIYLSLVG     dbPAF
23        AGTDDYIYLSLVGSA     dbPAF

※ Protein-Protein Interaction

Network

Interaction

Source

P09917

P49137

HPRD

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction