| Tag | Content |
|---|---|
| UniProt Accession | IFIT1_HUMAN; P09914; |
| Entrez ID | 3434 |
| GenBank Protein ID | NM_001270928.1; NM_001270929.1; NM_001270930.1; NM_001548.4; |
| GenBank Nucleotide ID | NP_001257857.1; NP_001257858.1; NP_001257859.1; NP_001539.3; |
| Protein Name | Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) |
| Gene Name | IFIT1; G10P1; IFI56; IFNAI1; ISG56 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. |
| Sequence (Fasta) | MSTNGDDHQV KDSLEQLRCH FTWELSIDDD EMPDLENRVL DQIEFLDTKY SVGIHNLLAY 60 VKHLKGQNEE ALKSLKEAEN LMQEEHDNQA NVRSLVTWGN FAWMYYHMGR LAEAQTYLDK 120 VENICKKLSN PFRYRMECPE IDCEEGWALL KCGGKNYERA KACFEKVLEV DPENPESSAG 180 YAISAYRLDG FKLATKNHKP FSLLPLRQAV RLNPDNGYIK VLLALKLQDE GQEAEGEKYI 240 EEALANMSSQ TYVFRYAAKF YRRKGSVDKA LELLKKALQE TPTSVLLHHQ IGLCYKAQMI 300 QIKEATKGQP RGQNREKLDK MIRSAIFHFE SAVEKKPTFE VAHLDLARMY IEAGNHRKAE 360 ENFQKLLCMK PVVEETMQDI HFHYGRFQEF QKKSDVNAII HYLKAIKIEQ ASLTRDKSIN 420 SLKKLVLRKL RRKALDLESL SLLGFVYKLE GNMNEALEYY ERALRLAADF ENSVRQGP 479 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | MESH:D004715
; Endometriosis MESH:D007251 ; Influenza, Human |
| DisGeNet (Curated) (count: 2) | C0014175; Endometriosis
C0021400; Influenza |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 6) | 2 ******MSTNGDDHQ dbPAF
218 RLNPDNGYIKVLLAL dbPAF 324 KLDKMIRSAIFHFES dbPAF 402 DVNAIIHYLKAIKIE dbPAF 412 AIKIEQASLTRDKSI dbPAF 60 GIHNLLAYVKHLKGQ dbPAF |
| Acetylation (count: 1) | 259 YVFRYAAKFYRRKGS PLMD |
| Ubiquitination (count: 1) | 151 EEGWALLKCGGKNYE PLMD |
| Malonylation (count: 2) | 259 YVFRYAAKFYRRKGS PLMD
336 FESAVEKKPTFEVAH PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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