| Tag | Content |
|---|---|
| UniProt Accession | PARP1_HUMAN; P09874; |
| Entrez ID | 142 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) |
| Gene Name | PARP1; ADPRT; PPOL |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of APLF and CHFR (PubMed:17396150). Positively regulates the transcription of MTUS1(view all) |
| Sequence (Fasta) | MAESSDKLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH WYHFSCFWKV 60 GHSIRHPDVE VDGFSELRWD DQQKVKKTAE AGGVTGKGQD GIGSKAEKTL GDFAAEYAKS 120 NRSTCKGCME KIEKGQVRLS KKMVDPEKPQ LGMIDRWYHP GCFVKNREEL GFRPEYSASQ 180 LKGFSLLATE DKEALKKQLP GVKSEGKRKG DEVDGVDEVA KKKSKKEKDK DSKLEKALKA 240 QNDLIWNIKD ELKKVCSTND LKELLIFNKQ QVPSGESAIL DRVADGMVFG ALLPCEECSG 300 QLVFKSDAYY CTGDVTAWTK CMVKTQTPNR KEWVTPKEFR EISYLKKLKV KKQDRIFPPE 360 TSASVAATPP PSTASAPAAV NSSASADKPL SNMKILTLGK LSRNKDEVKA MIEKLGGKLT 420 GTANKASLCI STKKEVEKMN KKMEEVKEAN IRVVSEDFLQ DVSASTKSLQ ELFLAHILSP 480 WGAEVKAEPV EVVAPRGKSG AALSKKSKGQ VKEEGINKSE KRMKLTLKGG AAVDPDSGLE 540 HSAHVLEKGG KVFSATLGLV DIVKGTNSYY KLQLLEDDKE NRYWIFRSWG RVGTVIGSNK 600 LEQMPSKEDA IEHFMKLYEE KTGNAWHSKN FTKYPKKFYP LEIDYGQDEE AVKKLTVNPG 660 TKSKLPKPVQ DLIKMIFDVE SMKKAMVEYE IDLQKMPLGK LSKRQIQAAY SILSEVQQAV 720 SQGSSDSQIL DLSNRFYTLI PHDFGMKKPP LLNNADSVQA KVEMLDNLLD IEVAYSLLRG 780 GSDDSSKDPI DVNYEKLKTD IKVVDRDSEE AEIIRKYVKN THATTHNAYD LEVIDIFKIE 840 REGECQRYKP FKQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM 900 VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG LGKTTPDPSA 960 NISLDGVDVP LGTGISSGVN DTSLLYNEYI VYDIAQVNLK YLLKLKFNFK TSLW 1015 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 25) (view all) | MESH:D000505
; Alopecia MESH:D000740 ; Anemia MESH:D001249 ; Asthma MESH:D050197 ; Atherosclerosis MESH:D001930 ; Brain Injuries MESH:D002545 ; Brain Ischemia |
| DisGeNet (Curated) (count: 23) (view all) | C0002170; Alopecia
C0002871; Anemia C0004096; Asthma C0004153; Atherosclerosis C0007786; Brain Ischemia C0011603; Dermatitis |
| HGMD (count: 7) (view all) | CM085119; Diabetic polyneuropathy, reduced risk, association with ?; Missense/nonsense
CM071915; Colorectal adenoma, assoc. with ?; Missense/nonsense CM077830; Breast cancer ?; Missense/nonsense CM077832; Breast cancer ?; Missense/nonsense CM042761; Prostate cancer, susceptibility, association with; Missense/nonsense CM077831; Colorectal cancer, increased risk, association with; Missense/nonsense |
| GWASdb (count: 6) | rs3219142; Longevity; Null
rs1136410; Multiple complex diseases; Null rs3219123; Alcohol and nictotine co-dependence; alcohol dependence|nicotine dependence rs2027440; Type 2 diabetes and 6 quantitative traits; type 2 diabetes mellitus rs3219090; Melanoma; skin melanoma rs3219060; LDL cholesterol; atherosclerosis|coronary artery disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 51) (view all) | 104 KGQDGIGSKAEKTLG dbPAF
177 LGFRPEYSASQLKGF dbPAF 179 FRPEYSASQLKGFSL dbPAF 185 ASQLKGFSLLATEDK dbPAF 189 KGFSLLATEDKEALK dbPAF 204 KQLPGVKSEGKRKGD dbPAF |
| Acetylation (count: 63) (view all) | 1006 LKYLLKLKFNFKTSL PLMD
105 GQDGIGSKAEKTLGD PLMD 108 GIGSKAEKTLGDFAA PLMD 119 DFAAEYAKSNRSTCK PLMD 131 TCKGCMEKIEKGQVR PLMD 134 GCMEKIEKGQVRLSK PLMD |
| Ubiquitination (count: 43) (view all) | 1006 LKYLLKLKFNFKTSL PLMD
108 GIGSKAEKTLGDFAA PLMD 119 DFAAEYAKSNRSTCK PLMD 134 GCMEKIEKGQVRLSK PLMD 142 GQVRLSKKMVDPEKP PLMD 148 KKMVDPEKPQLGMID PLMD |
| Sumoylation (count: 33) (view all) | 105 GQDGIGSKAEKTLGD PLMD
148 KKMVDPEKPQLGMID PLMD 192 SLLATEDKEALKKQL PLMD 203 KKQLPGVKSEGKRKG PLMD 225 EVAKKKSKKEKDKDS PLMD 239 SKLEKALKAQNDLIW PLMD |
| Malonylation (count: 3) | 196 TEDKEALKKQLPGVK PLMD
548 HSAHVLEKGGKVFSA PLMD 683 IFDVESMKKAMVEYE PLMD |
| Methylation (count: 2) | 508 AALSKKSKGQVKEEG PLMD
674 KPVQDLIKMIFDVES PLMD |