P09601

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	HMOX1_HUMAN; P09601;
Entrez ID	3162
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Heme oxygenase 1 (HO-1) (EC 1.14.14.18)
Gene Name	HMOX1; HO; HO1
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. Functional Description Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Sequence (Fasta)	MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA 60 LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE 120 VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQ 180 LYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA 240 SNKVQDSAPV ETPRGKPPLN TRSQAPLLRW VLTLSFLVAT VAVGLYAM 289 Fasta Sequence >P09601\|HMOX1; HO; HO1\|Homo sapiens (Human) MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Ubiquitination	Renal cancer/carcinoma		P		22689053
1	[Reference]: TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 63) (view all)	MESH:D058186 ; Acute Kidney Injury MESH:D000326 ; Adrenoleukodystrophy MESH:D000544 ; Alzheimer Disease MESH:D000743 ; Anemia, Hemolytic MESH:D001249 ; Asthma MESH:D001778 ; Blood Coagulation Disorders MESH:D001943 ; Breast Neoplasms MESH:D006332 ; Cardiomegaly MESH:D002340 ; Carotid Artery Diseases MESH:D002543 ; Cerebral Hemorrhage MESH:D056486 ; Chemical and Drug Induced Liver Injury MESH:D003092 ; Colitis MESH:D003324 ; Coronary Artery Disease MESH:D003877 ; Dermatitis, Contact MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D003924 ; Diabetes Mellitus, Type 2 MESH:D003925 ; Diabetic Angiopathies MESH:D064420 ; Drug-Related Side Effects and Adverse Reactions MESH:D005355 ; Fibrosis MESH:D018589 ; Gastroparesis MESH:D006130 ; Growth Disorders MESH:D006333 ; Heart Failure MESH:C564200 ; Heme Oxygenase 1 Deficiency MESH:D006461 ; Hemolysis MESH:D006505 ; Hepatitis MESH:D006530 ; Hepatorenal Syndrome MESH:D006946 ; Hyperinsulinism MESH:D006965 ; Hyperplasia MESH:D006973 ; Hypertension MESH:D007249 ; Inflammation MESH:D007333 ; Insulin Resistance MESH:D019189 ; Iron Metabolism Disorders MESH:D007511 ; Ischemia MESH:D007676 ; Kidney Failure, Chronic MESH:D007859 ; Learning Disorders MESH:D007898 ; Leishmaniasis, Visceral MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D008107 ; Liver Diseases MESH:D008113 ; Liver Neoplasms MESH:D055370 ; Lung Injury MESH:D008175 ; Lung Neoplasms MESH:D008325 ; Mammary Neoplasms, Experimental MESH:D034721 ; Mastocytosis, Systemic MESH:D017202 ; Myocardial Ischemia MESH:D009361 ; Neoplasm Invasiveness MESH:D019636 ; Neurodegenerative Diseases MESH:D013226 ; Status Epilepticus MESH:D009765 ; Obesity MESH:D010182 ; Pancreatic Diseases MESH:D010300 ; Parkinson Disease MESH:D011014 ; Pneumonia MESH:D011225 ; Pre-Eclampsia MESH:D011471 ; Prostatic Neoplasms MESH:D029424 ; Pulmonary Disease, Chronic Obstructive MESH:D011656 ; Pulmonary Emphysema MESH:D011658 ; Pulmonary Fibrosis MESH:D015427 ; Reperfusion Injury MESH:D012164 ; Retinal Diseases MESH:C564616 ; Spinocerebellar Ataxia 17 MESH:D013274 ; Stomach Neoplasms MESH:D013927 ; Thrombosis MESH:D057772 ; Vascular System Injuries MESH:D014947 ; Wounds and Injuries
DisGeNet (Curated) (count: 70) (view all)	C0002395; Alzheimer's Disease C0002878; Anemia, Hemolytic C0004096; Asthma C0005779; Blood Coagulation Disorders C0007273; Carotid Artery Diseases C0009319; Colitis C0011616; Contact Dermatitis C0011853; Diabetes Mellitus, Experimental C0011860; Diabetes Mellitus, Non-Insulin-Dependent C0011875; Diabetic Angiopathies C0012715; Iron Metabolism Disorders C0016059; Fibrosis C0018273; Growth Disorders C0018800; Cardiomegaly C0018801; Heart failure C0018965; Hematuria C0019054; Hemolysis (disorder) C0019158; Hepatitis C0019209; Hepatomegaly C0019212; Hepatorenal Syndrome C0020459; Hyperinsulinism C0020507; Hyperplasia C0020538; Hypertensive disease C0021368; Inflammation C0021655; Insulin Resistance C0022116; Ischemia C0022661; Kidney Failure, Chronic C0023186; Learning Disorders C0023290; Leishmaniasis, Visceral C0023893; Liver Cirrhosis, Experimental C0023895; Liver diseases C0023903; Liver neoplasms C0024117; Chronic Obstructive Airway Disease C0024121; Lung Neoplasms C0024668; Mammary Neoplasms, Experimental C0027626; Neoplasm Invasiveness C0028754; Obesity C0030286; Pancreatic Diseases C0030567; Parkinson Disease C0032285; Pneumonia C0032914; Pre-Eclampsia C0033578; Prostatic Neoplasms C0033687; Proteinuria C0034067; Pulmonary Emphysema C0034069; Pulmonary Fibrosis C0035126; Reperfusion Injury C0035309; Retinal Diseases C0036341; Schizophrenia C0038220; Status Epilepticus C0038356; Stomach Neoplasms C0040053; Thrombosis C0041755; Adverse reaction to drug C0151686; Growth retardation C0151744; Myocardial Ischemia C0152020; Gastroparesis C0162309; Adrenoleukodystrophy C0221013; Mastocytosis, Systemic C0273115; Lung Injury C0456070; Growth delay C0524851; Neurodegenerative Disorders C0878787; Growth failure C1458155; Mammary Neoplasms C1837385; Poor growth C1846707; SPINOCEREBELLAR ATAXIA 17 C1956346; Coronary Artery Disease C2609414; Acute kidney injury C2937358; Cerebral Hemorrhage C3552463; Very poor growth C4020899; Autosomal recessive predisposition C4277682; Chemical and Drug Induced Liver Injury
HGMD (count: 7) (view all)	CE000297; Emphysema, smoking induced, association with; Repeat variations CE057924; Cerebral aneurysms, assoc. with ?; Repeat variations CE085027; Rheumatoid arthritis disease modifier, assoc. with; Repeat variations CE030373; Oxidant injury, association with; Repeat variations CD991754; Haem oxygenase 1 deficiency; Small deletions CG994936; Haem oxygenase 1 deficiency; Gross deletions CR035866; Hypertension in women, association with; Regulatory
GWASdb (count: 5)	rs2071748; Obesity-related traits; obesity rs8140370; HDL cholesterol; cholesterol ester storage disease\|cholesterol embolism\|coronary artery disease rs2285112; Obesity-related traits; obesity rs17880056; HDL cholesterol; cholesterol ester storage disease\|cholesterol embolism\|coronary artery disease rs11555832; HDL cholesterol; cholesterol ester storage disease\|cholesterol embolism\|coronary artery disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 12) (view all)	108 WQEVIPYTPAMQRYV dbPAF 114 YTPAMQRYVKRLHEV dbPAF 137 VAHAYTRYLGDLSGG dbPAF 188 LYRSRMNSLEMTPAV dbPAF 192 RMNSLEMTPAVRQRV dbPAF 229 THDTKDQSPSRAPGL dbPAF 231 DTKDQSPSRAPGLRQ dbPAF 252 QDSAPVETPRGKPPL dbPAF 286 ATVAVGLYAM***** dbPAF 53 GFKLVMASLYHIYVA dbPAF 55 KLVMASLYHIYVALE dbPAF 58 MASLYHIYVALEEEI dbPAF
Acetylation (count: 2)	18 QDLSEALKEATKEVH PLMD 39 EFMRNFQKGQVTRDG PLMD
Ubiquitination (count: 10) (view all)	148 LSGGQVLKKIAQKAL PLMD 153 VLKKIAQKALDLPSS PLMD 177 PNIASATKFKQLYRS PLMD 179 IASATKFKQLYRSRM PLMD 18 QDLSEALKEATKEVH PLMD 243 LRQRASNKVQDSAPV PLMD 256 PVETPRGKPPLNTRS PLMD 39 EFMRNFQKGQVTRDG PLMD 69 EEEIERNKESPVFAP PLMD 86 FPEELHRKAALEQDL PLMD
Glycation (count: 3)	204 QRVIEEAKTAFLLNI PLMD 48 QVTRDGFKLVMASLY PLMD 69 EEEIERNKESPVFAP PLMD
Malonylation (count: 4)	18 QDLSEALKEATKEVH PLMD 22 EALKEATKEVHTQAE PLMD 243 LRQRASNKVQDSAPV PLMD 39 EFMRNFQKGQVTRDG PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

E7ETZ9	P09601	BioGRID
O60575	P09601	BioGRID
P04424	P09601	IntAct
P06276	P09601	BioGRID
P09601	P09601	HPRD
P09601	P16435	HPRD
P09601	P20594	BioGRID
P09601	P29475	HPRD
P09601	P30043	HPRD
P09601	P31749	HPRD; MINT
P09601	P35226	BioGRID
P09601	P50748	BioGRID
P09601	Q71DI3	BioGRID
P09601	Q86UQ4	BioGRID