| Tag | Content |
|---|---|
| UniProt Accession | TPM1_HUMAN; P09493; |
| Entrez ID | 7168 |
| GenBank Protein ID | NM_000366.5; NM_001018004.1; NM_001018005.1; NM_001018006.1; NM_001018007.1; NM_001018008.1; NM_001018020.1; NM_001301244.1; NM_001330344.1; NM_001330346.1; NM_001330351.1; |
| GenBank Nucleotide ID | NP_000357.3; NP_001018004.1; NP_001018005.1; NP_001018006.1; NP_001018007.1; NP_001018008.1; NP_001018020.1; NP_001288173.1; NP_001317273.1; NP_001317275.1; NP_001317280.1; |
| Protein Name | Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) |
| Gene Name | TPM1; C15orf13; TMSA |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
| Sequence (Fasta) | MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY 60 SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 120 DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE 180 ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE 240 FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI 285 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 8) (view all) | MESH:C567507
; Cardiomyopathy, Dilated, 1y MESH:C566170 ; Cardiomyopathy, Familial Hypertrophic, 3 MESH:D024741 ; Cardiomyopathy, Hypertrophic, Familial MESH:D004938 ; Esophageal Neoplasms MESH:C562729 ; Esophageal Squamous Cell Carcinoma MESH:D006973 ; Hypertension |
| HGMD (count: 13) (view all) | CM014115; Cardiomyopathy, dilated; Missense/nonsense
CM014116; Cardiomyopathy, dilated; Missense/nonsense CM033042; Cardiomyopathy, hypertrophic; Missense/nonsense CM961380; Cardiomyopathy, hypertrophic; Missense/nonsense CM961381; Cardiomyopathy, hypertrophic; Missense/nonsense CM010475; Cardiomyopathy, hypertrophic; Missense/nonsense |
| GWASdb (count: 5) | rs11071720; Mean platelet volume; myocardial infarction|hematopoietic system disease
rs6494387; Type 2 diabetes; type 2 diabetes mellitus rs1574311; Response to alcohol consumption (flushing response); alcohol abuse|alcohol dependence rs7162932; LDL cholesterol; atherosclerosis|coronary artery disease rs7162932; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 18) (view all) | 162 AEDADRKYEEVARKL dbPAF
174 RKLVIIESDLERAEE dbPAF 199 ELEEELKTVTNNLKS dbPAF 201 EEELKTVTNNLKSLE dbPAF 206 TVTNNLKSLEAQAEK dbPAF 214 LEAQAEKYSQKEDRY dbPAF |
| Acetylation (count: 5) | 149 EIQEIQLKEAKHIAE PLMD
152 EIQLKEAKHIAEDAD PLMD 161 IAEDADRKYEEVARK PLMD 251 RSVTKLEKSIDDLED PLMD 29 AEQAEADKKAAEDRS PLMD |
| Ubiquitination (count: 9) (view all) | 149 EIQEIQLKEAKHIAE PLMD
152 EIQLKEAKHIAEDAD PLMD 168 KYEEVARKLVIIESD PLMD 213 SLEAQAEKYSQKEDR PLMD 226 DRYEEEIKVLSDKLK PLMD 251 RSVTKLEKSIDDLED PLMD |
| Glycation (count: 1) | 217 QAEKYSQKEDRYEEE PLMD |
| Malonylation (count: 5) | 128 DESERGMKVIESRAQ PLMD
136 VIESRAQKDEEKMEI PLMD 205 KTVTNNLKSLEAQAE PLMD 37 KAAEDRSKQLEDELV PLMD 48 DELVSLQKKLKGTED PLMD |
| Methylation (count: 1) | 161 IAEDADRKYEEVARK PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |