Tag | Content |
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UniProt Accession | KPCD_RAT; P09215; |
Entrez ID | 170538 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] |
Gene Name | Prkcd; Pkcd |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of the deat(view all) |
Sequence (Fasta) | MAPFLRISFN SYELGSLQAE DDASQPFCAV KMKEALTTDR GKTLVQKKPT MYPEWKSTFD 60 AHIYEGRVIQ IVLMRAAEDP MSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMCVQY 120 FLEDGDCKQS MRSEEEAMFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKEFVW 180 GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TATNSRDTIF QKERFNIDMP HRFKVYNYMS 240 PTFCDHCGTL LWGLVKQGLK CEDCGMNVHH KCREKVANLC GINQKLLAEA LNQVTQKASR 300 KPETPETVGI YQGFEKKTAV SGNDIPDNNG TYGKIWEGSN RCRLENFTFQ KVLGKGSFGK 360 VLLAELKGKE RYFAIKYLKK DVVLIDDDVE CTMVEKRVLA LAWENPFLTH LICTFQTKDH 420 LFFVMEFLNG GDLMFHIQDK GRFELYRATF YAAEIICGLQ FLHGKGIIYR DLKLDNVMLD 480 KDGHIKIADF GMCKENIFGE NRASTFCGTP DYIAPEILQG LKYSFSVDWW SFGVLLYEML 540 IGQSPFHGDD EDELFESIRV DTPHYPRWIT KESKDIMEKL FERDPAKRLG VTGNIRLHPF 600 FKTINWNLLE KRKVEPPFKP KVKSPSDYSN FDPEFLNEKP QLSFSDKNLI DSMDQTAFKG 660 FSFVNPKYEQ FLE 674 |
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Database | Annotation |
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CTD (Curated) (count: 8) (view all) | OMIM:615559
; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE III MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D006973 ; Hypertension MESH:D007414 ; Intestinal Neoplasms MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D020258 ; Neurotoxicity Syndromes |
PTM | Modification Sites |
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Phosphorylation (count: 23) (view all) | 155 IKQAKIHYIKNHEFI dbPAF
215 CTGTATNSRDTIFQK dbPAF 218 TATNSRDTIFQKERF dbPAF 295 AEALNQVTQKASRKP dbPAF 304 KASRKPETPETVGIY dbPAF 311 TPETVGIYQGFEKKT dbPAF |
Ubiquitination (count: 1) | 297 ALNQVTQKASRKPET PLMD |