P09215

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession KPCD_RAT; P09215;
Entrez ID 170538
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]
Gene Name Prkcd; Pkcd
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionCalcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of the deat(view all)
Sequence
(Fasta)
MAPFLRISFN SYELGSLQAE DDASQPFCAV KMKEALTTDR GKTLVQKKPT MYPEWKSTFD 60
AHIYEGRVIQ IVLMRAAEDP MSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMCVQY 120
FLEDGDCKQS MRSEEEAMFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKEFVW 180
GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TATNSRDTIF QKERFNIDMP HRFKVYNYMS 240
PTFCDHCGTL LWGLVKQGLK CEDCGMNVHH KCREKVANLC GINQKLLAEA LNQVTQKASR 300
KPETPETVGI YQGFEKKTAV SGNDIPDNNG TYGKIWEGSN RCRLENFTFQ KVLGKGSFGK 360
VLLAELKGKE RYFAIKYLKK DVVLIDDDVE CTMVEKRVLA LAWENPFLTH LICTFQTKDH 420
LFFVMEFLNG GDLMFHIQDK GRFELYRATF YAAEIICGLQ FLHGKGIIYR DLKLDNVMLD 480
KDGHIKIADF GMCKENIFGE NRASTFCGTP DYIAPEILQG LKYSFSVDWW SFGVLLYEML 540
IGQSPFHGDD EDELFESIRV DTPHYPRWIT KESKDIMEKL FERDPAKRLG VTGNIRLHPF 600
FKTINWNLLE KRKVEPPFKP KVKSPSDYSN FDPEFLNEKP QLSFSDKNLI DSMDQTAFKG 660
FSFVNPKYEQ FLE 674

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationParkinson's diseasePT50524107416
[Reference]: These changes correlated well with the increased TUNEL stain (Fig. 2Ac) with a significantly increased number of apoptotic cells (P < 0?01, Fig. 2B) following PMA treatment compared to untreated controls

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 8)
(view all)
OMIM:615559 ; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE III
MESH:D003921 ; Diabetes Mellitus, Experimental
MESH:D006973 ; Hypertension
MESH:D007414 ; Intestinal Neoplasms
MESH:D008106 ; Liver Cirrhosis, Experimental
MESH:D020258 ; Neurotoxicity Syndromes

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 23)
(view all)
155       IKQAKIHYIKNHEFI     dbPAF
215       CTGTATNSRDTIFQK     dbPAF
218       TATNSRDTIFQKERF     dbPAF
295       AEALNQVTQKASRKP     dbPAF
304       KASRKPETPETVGIY     dbPAF
311       TPETVGIYQGFEKKT     dbPAF
Ubiquitination
(count: 1)
297       ALNQVTQKASRKPET     PLMD