| Tag | Content |
|---|---|
| UniProt Accession | GSTP1_HUMAN; P09211; |
| Entrez ID | 2950 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) |
| Gene Name | GSTP1; FAEES3; GST3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. |
| Sequence (Fasta) | MPPYTVVYFP VRGRCAALRM LLADQGQSWK EEVVTVETWQ EGSLKASCLY GQLPKFQDGD 60 LTLYQSNTIL RHLGRTLGLY GKDQQEAALV DMVNDGVEDL RCKYISLIYT NYEAGKDDYV 120 KALPGQLKPF ETLLSQNQGG KTFIVGDQIS FADYNLLDLL LIHEVLAPGC LDAFPLLSAY 180 VGRLSARPKL KAFLASPEYV NLPINGNGKQ 211 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 41) (view all) | MESH:D054058
; Acute Coronary Syndrome MESH:D058186 ; Acute Kidney Injury MESH:D019969 ; Amphetamine-Related Disorders MESH:D000690 ; Amyotrophic Lateral Sclerosis MESH:D001249 ; Asthma MESH:D001321 ; Autistic Disorder |
| DisGeNet (Curated) (count: 43) (view all) | C0002736; Amyotrophic Lateral Sclerosis
C0004096; Asthma C0004352; Autistic Disorder C0005695; Bladder Neoplasm C0007131; Non-Small Cell Lung Carcinoma C0007134; Renal Cell Carcinoma |
| HGMD (count: 3) | CM990713; Oral cancer, association with; Missense/nonsense
CM992339; Oral cancer in light smokers, association with; Missense/nonsense CM077577; Increased activity, association with; Missense/nonsense |
| GWASdb (count: 6) | rs1695; Drug response to Fluorouracil; Null
rs1695; Drug response to Cisplatin; Null rs1695; Drug response to Cyclophosphamide; Null rs1138272; Drug response to Thiotepa; Null rs1871042; Red blood cell traits; hematopoietic system disease rs947895; Red blood cell traits; hematopoietic system disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 16) (view all) | 109 CKYISLIYTNYEAGK dbPAF
110 KYISLIYTNYEAGKD dbPAF 112 ISLIYTNYEAGKDDY dbPAF 132 GQLKPFETLLSQNQG dbPAF 135 KPFETLLSQNQGGKT dbPAF 185 SAYVGRLSARPKLKA dbPAF |
| Acetylation (count: 6) | 116 YTNYEAGKDDYVKAL PLMD
121 AGKDDYVKALPGQLK PLMD 128 KALPGQLKPFETLLS PLMD 189 GRLSARPKLKAFLAS PLMD 209 LPINGNGKQ****** PLMD 55 CLYGQLPKFQDGDLT PLMD |
| Ubiquitination (count: 8) (view all) | 103 GVEDLRCKYISLIYT PLMD
121 AGKDDYVKALPGQLK PLMD 128 KALPGQLKPFETLLS PLMD 189 GRLSARPKLKAFLAS PLMD 191 LSARPKLKAFLASPE PLMD 209 LPINGNGKQ****** PLMD |
| Methylation (count: 1) | 209 LPINGNGKQ****** PLMD |