P08833

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession IBP1_HUMAN; P08833;
Entrez ID 3484
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12)
Gene Name IGFBP1; IBP1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionIGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Sequence
(Fasta)
MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE VTRSAGCGCC 60
PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG QGACVQESDA SAPHAAEAGS 120
PESPESTEIT EEELLDNFHL MAPSEEDHSI LWDAISTYDG SKALHVTNIK KWKEPCRIEL 180
YRVVESLAKA QETSGEEISK FYLPNCNKNG FYHSRQCETS MDGEAGLCWC VYPWNGKRIP 240
GSPEIRGDPN CQIYFNVQN

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationFetal growth restrictionUS12620143870
[Reference]: Site-specific IGFBP-1 hyper-phosphorylation in fetal growth restriction: clinical and functional relevance.
2Serine PhosphorylationFetal growth restrictionUS14419193607
[Reference]: Functional and complementary phosphorylation state attributes of human insulin-like growth factor-binding protein-1 (IGFBP-1) isoforms resolved by free flow electrophoresis.
3Serine PhosphorylationFetal growth restrictionUS19420143870
[Reference]: We suggest that site-specific increase in IGFBP-1 phosphorylation limits IGF-I bioavailability, which directly contributes to the development of FGR. This study delineates the potential role of higher phosphorylation of IGFBP-1 in FGR and provides the basis to substantiate these findings with larger sample size.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 9)
(view all)
MESH:D000022 ; Abortion, Spontaneous
MESH:D058186 ; Acute Kidney Injury
MESH:D003110 ; Colonic Neoplasms
MESH:D064420 ; Drug-Related Side Effects and Adverse Reactions
MESH:D004715 ; Endometriosis
MESH:D008103 ; Liver Cirrhosis
DisGeNet (Curated)
(count: 9)
(view all)
C0000786; Spontaneous abortion
C0009375; Colonic Neoplasms
C0014175; Endometriosis
C0023890; Liver Cirrhosis
C0023892; Biliary cirrhosis
C0023893; Liver Cirrhosis, Experimental
GWASdb
(count: 2)
rs1874479; Obesity (extreme); obesity
rs4619; Height; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 9)
(view all)
108       QGACVQESDASAPHA     dbPAF
120       PHAAEAGSPESPEST     dbPAF
123       AEAGSPESPESTEIT     dbPAF
126       GSPESPESTEITEEE     dbPAF
127       SPESPESTEITEEEL     dbPAF
144       NFHLMAPSEEDHSIL     dbPAF