Tag | Content |
---|---|
UniProt Accession | RASK_RAT; P08644; |
Entrez ID | 24525 |
GenBank Protein ID | NM_031515.3; XM_008763354.2; XM_017592442.1; XM_017592443.1; |
GenBank Nucleotide ID | NP_113703.1; XP_008761576.1; XP_017447931.1; XP_017447932.1; |
Protein Name | GTPase KRas (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed] |
Gene Name | Kras; Kras2 |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation (PubMed:3110778). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity). |
Sequence (Fasta) | MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 60 QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL 120 PSRTVDTKQA QELARSYGIP FIETSAKTRQ RVEDAFYTLV REIRQYRLKK ISKEEKTPGC 180 VKIKKCVIM |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 52) (view all) | MESH:D000230
; Adenocarcinoma MESH:D018263 ; Adenocarcinoma, Follicular MESH:C538231 ; Adenocarcinoma of lung MESH:D000236 ; Adenoma MESH:D000740 ; Anemia MESH:D001171 ; Arthritis, Juvenile |
PTM | Modification Sites |
---|---|
Ubiquitination (count: 1) | 128 PSRTVDTKQAQELAR PLMD |
Methylation (count: 1) | 42 TIEDSYRKQVVIDGE PLMD |