P08644

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession RASK_RAT; P08644;
Entrez ID 24525
GenBank Protein ID NM_031515.3; XM_008763354.2; XM_017592442.1; XM_017592443.1;
GenBank Nucleotide ID NP_113703.1; XP_008761576.1; XP_017447931.1; XP_017447932.1;
Protein Name GTPase KRas (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene Name Kras; Kras2
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionRas proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation (PubMed:3110778). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity).
Sequence
(Fasta)
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 60
QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL 120
PSRTVDTKQA QELARSYGIP FIETSAKTRQ RVEDAFYTLV REIRQYRLKK ISKEEKTPGC 180
VKIKKCVIM

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationCrohn's diseaseU23970928
[Reference]: The result shows that the phosphorylation of the Ras, Raf-1, MEK-1, and ERK-1/2 proteins and the expression of the corresponding mRNAs in the colon tissue of CD rat were significantly higher than the normal control group.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 52)
(view all)
MESH:D000230 ; Adenocarcinoma
MESH:D018263 ; Adenocarcinoma, Follicular
MESH:C538231 ; Adenocarcinoma of lung
MESH:D000236 ; Adenoma
MESH:D000740 ; Anemia
MESH:D001171 ; Arthritis, Juvenile

※ PTM Sites

PTM Modification Sites
Ubiquitination
(count: 1)
128       PSRTVDTKQAQELAR     PLMD
Methylation
(count: 1)
42        TIEDSYRKQVVIDGE     PLMD