P08621

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession RU17_HUMAN; P08621;
Entrez ID 6625
GenBank Protein ID NM_001301069.1; NM_003089.5;
GenBank Nucleotide ID NP_001287998.1; NP_003080.2;
Protein Name U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene Name SNRNP70; RNPU1Z; RPU1; SNRP70; U1AP1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionComponent of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
Sequence
(Fasta)		MTQFLPPNLL ALFAPRDPIP YLPPLEKLPH EKHHNQPYCG IAPYIREFED PRDAPPPTRA 60
ETREERMERK RREKIERRQQ EVETELKMWD PHNDPNAQGD AFKTLFVARV NYDTTESKLR 120
REFEVYGPIK RIHMVYSKRS GKPRGYAFIE YEHERDMHSA YKHADGKKID GRRVLVDVER 180
GRTVKGWRPR RLGGGLGGTR RGGADVNIRH SGRDDTSRYD ERPGPSPLPH RDRDRDRERE 240
RRERSRERDK ERERRRSRSR DRRRRSRSRD KEERRRSRER SKDKDRDRKR RSSRSRERAR 300
RERERKEELR GGGGDMAEPS EAGDAPPDDG PPGELGPDGP DGPEEKGRDR DRERRRSHRS 360
ERERRRDRDR DRDRDREHKR GERGSERGRD EARGGGGGQD NGLEGLGNDS RDMYMESEGG 420
DGYLAPENGY LMEAAPE 438

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationSystemic lupus erythematosusPS14012548559
[Reference]: We further demonstrated that P140 is recognized by antibodies from lupus patients and binds to various HLA DR molecules, offering new hope for manipulating T cell response in humans.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 1)		rs3795055; Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide); neutropenia

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 26)
(view all)		 112       LFVARVNYDTTESKL     dbPAF
117       VNYDTTESKLRREFE     dbPAF
126       LRREFEVYGPIKRIH     dbPAF
137       KRIHMVYSKRSGKPR     dbPAF
140       HMVYSKRSGKPRGYA     dbPAF
146       RSGKPRGYAFIEYEH     dbPAF
Acetylation
(count: 8)
(view all)		 103       NAQGDAFKTLFVARV     PLMD
118       NYDTTESKLRREFEV     PLMD
130       FEVYGPIKRIHMVYS     PLMD
162       RDMHSAYKHADGKKI     PLMD
27        PYLPPLEKLPHEKHH     PLMD
32        LEKLPHEKHHNQPYC     PLMD
Ubiquitination
(count: 9)
(view all)		 103       NAQGDAFKTLFVARV     PLMD
118       NYDTTESKLRREFEV     PLMD
130       FEVYGPIKRIHMVYS     PLMD
138       RIHMVYSKRSGKPRG     PLMD
167       AYKHADGKKIDGRRV     PLMD
27        PYLPPLEKLPHEKHH     PLMD
Methylation
(count: 1)		 130       FEVYGPIKRIHMVYS     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource