P08559

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	ODPA_HUMAN; P08559;
Entrez ID	5160
GenBank Protein ID	NM_000284.3; NM_001173454.1; NM_001173455.1; NM_001173456.1;
GenBank Nucleotide ID	NP_000275.1; NP_001166925.1; NP_001166926.1; NP_001166927.1;
Protein Name	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)
Gene Name	PDHA1; PHE1A
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Functional Description The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Sequence (Fasta)	MRKMLAAVSR VLSGASQKPA SRVLVASRNF ANDATFEIKK CDLHRLEEGP PVTTVLTRED 60 GLKYYRMMQT VRRMELKADQ LYKQKIIRGF CHLCDGQEAC CVGLEAGINP TDHLITAYRA 120 HGFTFTRGLS VREILAELTG RKGGCAKGKG GSMHMYAKNF YGGNGIVGAQ VPLGAGIALA 180 CKYNGKDEVC LTLYGDGAAN QGQIFEAYNM AALWKLPCIF ICENNRYGMG TSVERAAAST 240 DYYKRGDFIP GLRVDGMDIL CVREATRFAA AYCRSGKGPI LMELQTYRYH GHSMSDPGVS 300 YRTREEIQEV RSKSDPIMLL KDRMVNSNLA SVEELKEIDV EVRKEIEDAA QFATADPEPP 360 LEELGYHIYS SDPPFEVRGA NQWIKFKSVS 391 Fasta Sequence >P08559\|PDHA1; PHE1A\|Homo sapiens (Human) MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Squamous cell carcinoma		U	S232	27498883
1	[Reference]: Patients with detectable 232 phosphorylation or expression of PDHK1 tend to have worse clinical outcome.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 8) (view all)	MESH:D000140 ; Acidosis, Lactic MESH:D018450 ; Disease Progression MESH:D017202 ; Myocardial Ischemia MESH:D010003 ; Osteoarthritis MESH:D011471 ; Prostatic Neoplasms MESH:D015325 ; Pyruvate Dehydrogenase Complex Deficiency Disease MESH:D015323 ; Pyruvate Metabolism, Inborn Errors MESH:D013274 ; Stomach Neoplasms

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 21) (view all)	116 NPTDHLITAYRAHGF dbPAF 118 TDHLITAYRAHGFTF dbPAF 139 REILAELTGRKGGCA dbPAF 152 CAKGKGGSMHMYAKN dbPAF 227 FICENNRYGMGTSVE dbPAF 231 NNRYGMGTSVERAAA dbPAF 232 NRYGMGTSVERAAAS dbPAF 240 VERAAASTDYYKRGD dbPAF 242 RAAASTDYYKRGDFI dbPAF 243 AAASTDYYKRGDFIP dbPAF 272 ATRFAAAYCRSGKGP dbPAF 289 MELQTYRYHGHSMSD dbPAF 293 TYRYHGHSMSDPGVS dbPAF 295 RYHGHSMSDPGVSYR dbPAF 300 SMSDPGVSYRTREEI dbPAF 301 MSDPGVSYRTREEIQ dbPAF 303 DPGVSYRTREEIQEV dbPAF 312 EEIQEVRSKSDPIML dbPAF 331 MVNSNLASVEELKEI dbPAF 366 PPLEELGYHIYSSDP dbPAF 369 EELGYHIYSSDPPFE dbPAF
Acetylation (count: 10) (view all)	244 AASTDYYKRGDFIPG PLMD 277 AAYCRSGKGPILMEL PLMD 313 EIQEVRSKSDPIMLL PLMD 321 SDPIMLLKDRMVNSN PLMD 336 LASVEELKEIDVEVR PLMD 385 RGANQWIKFKSVS** PLMD 63 LTREDGLKYYRMMQT PLMD 77 TVRRMELKADQLYKQ PLMD 83 LKADQLYKQKIIRGF PLMD 85 ADQLYKQKIIRGFCH PLMD
Ubiquitination (count: 9) (view all)	244 AASTDYYKRGDFIPG PLMD 277 AAYCRSGKGPILMEL PLMD 313 EIQEVRSKSDPIMLL PLMD 321 SDPIMLLKDRMVNSN PLMD 336 LASVEELKEIDVEVR PLMD 385 RGANQWIKFKSVS** PLMD 39 NDATFEIKKCDLHRL PLMD 63 LTREDGLKYYRMMQT PLMD 77 TVRRMELKADQLYKQ PLMD
Malonylation (count: 4)	244 AASTDYYKRGDFIPG PLMD 313 EIQEVRSKSDPIMLL PLMD 321 SDPIMLLKDRMVNSN PLMD 77 TVRRMELKADQLYKQ PLMD
Succinylation (count: 4)	244 AASTDYYKRGDFIPG PLMD 321 SDPIMLLKDRMVNSN PLMD 77 TVRRMELKADQLYKQ PLMD 83 LKADQLYKQKIIRGF PLMD