P08413

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession KCC2B_RAT; P08413;
Entrez ID 24245
GenBank Protein ID NM_001042356.1; NM_021739.2;
GenBank Nucleotide ID NP_001035815.1; NP_068507.2;
Protein Name Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
Gene Name Camk2b
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionCalcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts(view all)
Sequence
(Fasta)
MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 60
EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 120
LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 180
LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 240
VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 300
KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK 360
NSSAITSPKG SLPPAALEPQ TTVIHNPVDG IKESSDSTNT TIEDEDAKAR KQEIIKTTEQ 420
LIEAVNNGDF EAYAKICDPG LTSFEPEALG NLVEGMDFHR FYFENLLAKN SKPIHTTILN 480
PHVHVIGEDA ACIAYIRLTQ YIDGQGRPRT SQSEETRVWH RPDGKWQNVH FHCSGAPVAP 540
LQ 543

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationDiabetes mellitusDT28723490331
[Reference]: The disturbance of hippocampal CaMKII/PKA/PKC phosphorylation in early experimental diabetes mellitus.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 5)
MESH:D019970 ; Cocaine-Related Disorders
MESH:D002189 ; Marijuana Abuse
MESH:D010623 ; Phencyclidine Abuse
MESH:D011605 ; Psychoses, Substance-Induced
MESH:D012559 ; Schizophrenia

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 39)
(view all)
107       EDIVAREYYSEADAS     dbPAF
14        CTRFTDEYQLYEDIG     dbPAF
17        FTDEYQLYEDIGKGA     dbPAF
223       DEDQHKLYQQIKAGA     dbPAF
231       QQIKAGAYDFPSPEW     dbPAF
235       AGAYDFPSPEWDTVT     dbPAF
Acetylation
(count: 6)
227       HKLYQQIKAGAYDFP     PLMD
268       ITAHEALKHPWVCQR     PLMD
292       QETVECLKKFNARRK     PLMD
33        SVVRRCVKLCTGHEY     PLMD
57        LSARDHQKLEREARI     PLMD
69        ARICRLLKHSNIVRL     PLMD
Ubiquitination
(count: 3)
246       DTVTPEAKNLINQML     PLMD
259       MLTINPAKRITAHEA     PLMD
57        LSARDHQKLEREARI     PLMD
Methylation
(count: 1)
221       FWDEDQHKLYQQIKA     PLMD