Tag | Content |
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UniProt Accession | KCC2B_RAT; P08413; |
Entrez ID | 24245 |
GenBank Protein ID | NM_001042356.1; NM_021739.2; |
GenBank Nucleotide ID | NP_001035815.1; NP_068507.2; |
Protein Name | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) |
Gene Name | Camk2b |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts(view all) |
Sequence (Fasta) | MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 60 EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 120 LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 180 LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 240 VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 300 KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK 360 NSSAITSPKG SLPPAALEPQ TTVIHNPVDG IKESSDSTNT TIEDEDAKAR KQEIIKTTEQ 420 LIEAVNNGDF EAYAKICDPG LTSFEPEALG NLVEGMDFHR FYFENLLAKN SKPIHTTILN 480 PHVHVIGEDA ACIAYIRLTQ YIDGQGRPRT SQSEETRVWH RPDGKWQNVH FHCSGAPVAP 540 LQ 543 |
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Database | Annotation |
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CTD (Curated) (count: 5) | MESH:D019970
; Cocaine-Related Disorders MESH:D002189 ; Marijuana Abuse MESH:D010623 ; Phencyclidine Abuse MESH:D011605 ; Psychoses, Substance-Induced MESH:D012559 ; Schizophrenia |
PTM | Modification Sites |
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Phosphorylation (count: 39) (view all) | 107 EDIVAREYYSEADAS dbPAF
14 CTRFTDEYQLYEDIG dbPAF 17 FTDEYQLYEDIGKGA dbPAF 223 DEDQHKLYQQIKAGA dbPAF 231 QQIKAGAYDFPSPEW dbPAF 235 AGAYDFPSPEWDTVT dbPAF |
Acetylation (count: 6) | 227 HKLYQQIKAGAYDFP PLMD
268 ITAHEALKHPWVCQR PLMD 292 QETVECLKKFNARRK PLMD 33 SVVRRCVKLCTGHEY PLMD 57 LSARDHQKLEREARI PLMD 69 ARICRLLKHSNIVRL PLMD |
Ubiquitination (count: 3) | 246 DTVTPEAKNLINQML PLMD
259 MLTINPAKRITAHEA PLMD 57 LSARDHQKLEREARI PLMD |
Methylation (count: 1) | 221 FWDEDQHKLYQQIKA PLMD |