| Tag | Content |
|---|---|
| UniProt Accession | DAF_HUMAN; P08174; |
| Entrez ID | 1604 |
| GenBank Protein ID | NM_000574.4; NM_001114752.2; NM_001300903.1; NM_001300904.1; |
| GenBank Nucleotide ID | NP_000565.1; NP_001108224.1; NP_001287832.1; NP_001287833.1; |
| Protein Name | Complement decay-accelerating factor (CD antigen CD55) |
| Gene Name | CD55; CR; DAF |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829).;(Microbial infection) Acts as a receptor for coxsackievirus A21, coxsackieviruses B1, B3 and B5 (PubMed:9151867). Acts as a receptor for human enterovirus 70 and D68 (Probable) (PubMed:8764022). Acts as a receptor for human echoviruses 6, 7, 11, 12, 20 and 21 (PubMed:7525274). |
| Sequence (Fasta) | MTVARPSVPA ALPLLGELPR LLLLVLLCLP AVWGDCGLPP DVPNAQPALE GRTSFPEDTV 60 ITYKCEESFV KIPGEKDSVI CLKGSQWSDI EEFCNRSCEV PTRLNSASLK QPYITQNYFP 120 VGTVVEYECR PGYRREPSLS PKLTCLQNLK WSTAVEFCKK KSCPNPGEIR NGQIDVPGGI 180 LFGATISFSC NTGYKLFGST SSFCLISGSS VQWSDPLPEC REIYCPAPPQ IDNGIIQGER 240 DHYGYRQSVT YACNKGFTMI GEHSIYCTVN NDEGEWSGPP PECRGKSLTS KVPPTVQKPT 300 TVNVPTTEVS PTSQKTTTKT TTPNAQATRS TPVSRTTKHF HETTPNKGSG TTSGTTRLLS 360 GHTCFTLTGL LGTLVTMGLL T 382 |
|
||||||||||||||||||||
| Database | Annotation |
|---|---|
| CTD (Curated) (count: 3) | MESH:D019969
; Amphetamine-Related Disorders MESH:D004715 ; Endometriosis MESH:D011504 ; Protein-Losing Enteropathies |
| DisGeNet (Curated) (count: 2) | C0014175; Endometriosis
C0236733; Amphetamine-Related Disorders |
| HGMD (count: 16) (view all) | CM004826; Cromer blood group; Missense/nonsense
CM004825; Cromer blood group; Missense/nonsense CM004827; Cromer blood group; Missense/nonsense CM004828; Cromer blood group; Missense/nonsense CM940333; Cromer blood group; Missense/nonsense CM076088; Cromer blood group; Missense/nonsense |
| GWASdb (count: 2) | rs2564978; Asthma (aspirin-intolerant); asthma
rs2564978; H1N1 influenza A virus infection; influenza |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 8) (view all) | 140 YRREPSLSPKLTCLQ dbPAF
162 VEFCKKKSCPNPGEI dbPAF 245 GERDHYGYRQSVTYA dbPAF 251 GYRQSVTYACNKGFT dbPAF 266 MIGEHSIYCTVNNDE dbPAF 306 PTTVNVPTTEVSPTS dbPAF |
| Acetylation (count: 2) | 142 REPSLSPKLTCLQNL PLMD
159 STAVEFCKKKSCPNP PLMD |
| Ubiquitination (count: 10) (view all) | 110 RLNSASLKQPYITQN PLMD
142 REPSLSPKLTCLQNL PLMD 150 LTCLQNLKWSTAVEF PLMD 159 STAVEFCKKKSCPNP PLMD 255 SVTYACNKGFTMIGE PLMD 291 RGKSLTSKVPPTVQK PLMD |
| Glycation (count: 2) | 142 REPSLSPKLTCLQNL PLMD
76 FVKIPGEKDSVICLK PLMD |
| Succinylation (count: 1) | 161 AVEFCKKKSCPNPGE PLMD |