| Tag | Content |
|---|---|
| UniProt Accession | CXA1_RAT; P08050; |
| Entrez ID | 24392 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) |
| Gene Name | Gja1; Cxn-43 |
| Organism | Rattus norvegicus |
| NCBI Taxa ID | 10116 |
| Functional Description | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Plays an essential role in gap junction communication in the ventricles (By similarity). |
| Sequence (Fasta) | MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS AFRCNTQQPG 60 CENVCYDKSF PISHVRFWVL QIIFVSVPTL LYLAHVFYVM RKEEKLNKKE EELKVAQTDG 120 VNVEMHLKQI EIKKFKYGIE EHGKVKMRGG LLRTYIISIL FKSVFEVAFL LIQWYIYGFS 180 LSAVYTCKRD PCPHQVDCFL SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV 240 KGRSDPYHAT TGPLSPSKDC GSPKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN 300 YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD NQNAKKVAAG HELQPLAIVD 360 QRPSSRASSR ASSRPRPDDL EI 383 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 19) (view all) | MESH:D000236
; Adenoma MESH:D001145 ; Arrhythmias, Cardiac MESH:C562831 ; Atrioventricular Septal Defect MESH:D001321 ; Autistic Disorder MESH:C537660 ; Basaran Yilmaz syndrome MESH:D003323 ; Coronary Aneurysm |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 33) (view all) | 137 IEIKKFKYGIEEHGK dbPAF
244 KDRVKGRSDPYHATT dbPAF 247 VKGRSDPYHATTGPL dbPAF 250 RSDPYHATTGPLSPS dbPAF 251 SDPYHATTGPLSPSK dbPAF 255 HATTGPLSPSKDCGS dbPAF |
| Acetylation (count: 3) | 109 KEEKLNKKEEELKVA PLMD
133 HLKQIEIKKFKYGIE PLMD 144 YGIEEHGKVKMRGGL PLMD |
| Ubiquitination (count: 7) (view all) | 109 KEEKLNKKEEELKVA PLMD
128 VNVEMHLKQIEIKKF PLMD 136 QIEIKKFKYGIEEHG PLMD 258 TGPLSPSKDCGSPKY PLMD 264 SKDCGSPKYAYFNGC PLMD 303 SSCRNYNKQASEQNW PLMD |