| Tag | Content |
|---|---|
| UniProt Accession | SP1_HUMAN; P08047; |
| Entrez ID | 6667 |
| GenBank Protein ID | NM_001251825.1; NM_003109.1; NM_138473.2; XM_011538696.2; |
| GenBank Nucleotide ID | NP_001238754.1; NP_003100.1; NP_612482.2; XP_011536998.1; |
| Protein Name | Transcription factor Sp1 |
| Gene Name | SP1; TSFP1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1. |
| Sequence (Fasta) | MSDQDHSMDE MTAVVKIEKG VGGNNGGNGN GGGAFSQARS SSTGSSSSTG GGGQESQPSP 60 LALLAATCSR IESPNENSNN SQGPSQSGGT GELDLTATQL SQGANGWQII SSSSGATPTS 120 KEQSGSSTNG SNGSESSKNR TVSGGQYVVA AAPNLQNQQV LTGLPGVMPN IQYQVIPQFQ 180 TVDGQQLQFA ATGAQVQQDG SGQIQIIPGA NQQIITNRGS GGNIIAAMPN LLQQAVPLQG 240 LANNVLSGQT QYVTNVPVAL NGNITLLPVN SVSAATLTPS SQAVTISSSG SQESGSQPVT 300 SGTTISSASL VSSQASSSSF FTNANSYSTT TTTSNMGIMN FTTSGSSGTN SQGQTPQRVS 360 GLQGSDALNI QQNQTSGGSL QAGQQKEGEQ NQQTQQQQIL IQPQLVQGGQ ALQALQAAPL 420 SGQTFTTQAI SQETLQNLQL QAVPNSGPII IRTPTVGPNG QVSWQTLQLQ NLQVQNPQAQ 480 TITLAPMQGV SLGQTSSSNT TLTPIASAAS IPAGTVTVNA AQLSSMPGLQ TINLSALGTS 540 GIQVHPIQGL PLAIANAPGD HGAQLGLHGA GGDGIHDDTA GGEEGENSPD AQPQAGRRTR 600 REACTCPYCK DSEGRGSGDP GKKKQHICHI QGCGKVYGKT SHLRAHLRWH TGERPFMCTW 660 SYCGKRFTRS DELQRHKRTH TGEKKFACPE CPKRFMRSDH LSKHIKTHQN KKGGPGVALS 720 VGTLPLDSGA GSEGSGTATP SALITTNMVA MEAICPEGIA RLANSGINVM QVADLQSINI 780 SGNGF 786 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 5) | MESH:D002471
; Cell Transformation, Neoplastic MESH:D006943 ; Hyperglycemia MESH:D009361 ; Neoplasm Invasiveness MESH:D009362 ; Neoplasm Metastasis MESH:D012878 ; Skin Neoplasms |
| GWASdb (count: 1) | rs34656641; Bone mineral density; bone resorption disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 47) (view all) | 101 DLTATQLSQGANGWQ dbPAF
12 DHSMDEMTAVVKIEK dbPAF 2 ******MSDQDHSMD dbPAF 278 SVSAATLTPSSQAVT dbPAF 36 GNGGGAFSQARSSST dbPAF 375 LNIQQNQTSGGSLQA dbPAF |
| Acetylation (count: 2) | 19 TAVVKIEKGVGGNNG PLMD
703 MRSDHLSKHIKTHQN PLMD |
| Ubiquitination (count: 4) | 19 TAVVKIEKGVGGNNG PLMD
610 ACTCPYCKDSEGRGS PLMD 685 RTHTGEKKFACPECP PLMD 712 IKTHQNKKGGPGVAL PLMD |
| Sumoylation (count: 1) | 16 DEMTAVVKIEKGVGG PLMD |