Tag | Content |
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UniProt Accession | RET_HUMAN; P07949; |
Entrez ID | 5979 |
GenBank Protein ID | NM_020630.4; NM_020975.4; |
GenBank Nucleotide ID | NP_065681.1; NP_066124.1; |
Protein Name | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] |
Gene Name | RET; CDHF12; CDHR16; PTC; RET51 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of(view all) |
Sequence (Fasta) | MAKATSGAAG LRLLLLLLLP LLGKVALGLY FSRDAYWEKL YVDQAAGTPL LYVHALRDAP 60 EEVPSFRLGQ HLYGTYRTRL HENNWICIQE DTGLLYLNRS LDHSSWEKLS VRNRGFPLLT 120 VYLKVFLSPT SLREGECQWP GCARVYFSFF NTSFPACSSL KPRELCFPET RPSFRIRENR 180 PPGTFHQFRL LPVQFLCPNI SVAYRLLEGE GLPFRCAPDS LEVSTRWALD REQREKYELV 240 AVCTVHAGAR EEVVMVPFPV TVYDEDDSAP TFPAGVDTAS AVVEFKRKED TVVATLRVFD 300 ADVVPASGEL VRRYTSTLLP GDTWAQQTFR VEHWPNETSV QANGSFVRAT VHDYRLVLNR 360 NLSISENRTM QLAVLVNDSD FQGPGAGVLL LHFNVSVLPV SLHLPSTYSL SVSRRARRFA 420 QIGKVCVENC QAFSGINVQY KLHSSGANCS TLGVVTSAED TSGILFVNDT KALRRPKCAE 480 LHYMVVATDQ QTSRQAQAQL LVTVEGSYVA EEAGCPLSCA VSKRRLECEE CGGLGSPTGR 540 CEWRQGDGKG ITRNFSTCSP STKTCPDGHC DVVETQDINI CPQDCLRGSI VGGHEPGEPR 600 GIKAGYGTCN CFPEEEKCFC EPEDIQDPLC DELCRTVIAA AVLFSFIVSV LLSAFCIHCY 660 HKFAHKPPIS SAEMTFRRPA QAFPVSYSSS GARRPSLDSM ENQVSVDAFK ILEDPKWEFP 720 RKNLVLGKTL GEGEFGKVVK ATAFHLKGRA GYTTVAVKML KENASPSELR DLLSEFNVLK 780 QVNHPHVIKL YGACSQDGPL LLIVEYAKYG SLRGFLRESR KVGPGYLGSG GSRNSSSLDH 840 PDERALTMGD LISFAWQISQ GMQYLAEMKL VHRDLAARNI LVAEGRKMKI SDFGLSRDVY 900 EEDSYVKRSQ GRIPVKWMAI ESLFDHIYTT QSDVWSFGVL LWEIVTLGGN PYPGIPPERL 960 FNLLKTGHRM ERPDNCSEEM YRLMLQCWKQ EPDKRPVFAD ISKDLEKMMV KRRDYLDLAA 1020 STPSDSLIYD DGLSEEETPL VDCNNAPLPR ALPSTWIENK LYGMSDPNWP GESPVPLTRA 1080 DGTNTGFPRY PNDSVYANWM LSPSAAKLMD TFDS 1115 |
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Database | Annotation |
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Cancer Gene Census | medullary thyroid, papillary thyroid, pheochromocytoma, NSCLC, Spitzoid tumour medullary thyroid, papillary thyroid, pheochromocytoma multiple endocrine neoplasia 2A/2B |
CTD (Curated) (count: 15) (view all) | MESH:D028226
; Amyloidosis, Familial MESH:D002051 ; Burkitt Lymphoma MESH:D018276 ; Carcinoma, Medullary MESH:D015179 ; Colorectal Neoplasms MESH:C536209 ; Congenital central hypoventilation syndrome MESH:C536911 ; Familial medullary thyroid carcinoma |
GWASdb (count: 18) (view all) | rs2506011; Hirschsprung's disease; Hirschsprung's disease
rs2435356; Multiple complex diseases; Null rs2435356; Hirschsprung's disease; Hirschsprung's disease rs2506021; Hirschsprung's disease; Hirschsprung's disease rs2435342; Hirschsprung's disease; Hirschsprung's disease rs12247456; Hypertension; hypertension |
PTM | Modification Sites |
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Phosphorylation (count: 30) (view all) | 1015 MMVKRRDYLDLAAST dbPAF
1029 TPSDSLIYDDGLSEE dbPAF 1062 TWIENKLYGMSDPNW dbPAF 1065 ENKLYGMSDPNWPGE dbPAF 1090 TNTGFPRYPNDSVYA dbPAF 1096 RYPNDSVYANWMLSP dbPAF |
Ubiquitination (count: 2) | 108 LDHSSWEKLSVRNRG PLMD
907 YEEDSYVKRSQGRIP PLMD |
Network | Interaction | ||
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A | B | Source | |