| Tag | Content |
|---|---|
| UniProt Accession | CATB_HUMAN; P07858; |
| Entrez ID | 1508 |
| GenBank Protein ID | NM_001908.4; NM_147780.3; NM_147781.3; NM_147782.3; NM_147783.3; XM_006716244.2; XM_006716245.2; XM_011543812.2; XM_017013097.1; XM_017013098.1; XM_017013099.1; XM_017013100.1; |
| GenBank Nucleotide ID | NP_001899.1; NP_680090.1; NP_680091.1; NP_680092.1; NP_680093.1; XP_006716307.1; XP_006716308.1; XP_011542114.1; XP_016868586.1; XP_016868587.1; XP_016868588.1; XP_016868589.1; |
| Protein Name | Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] |
| Gene Name | CTSB; CPSB |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. |
| Sequence (Fasta) | MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT WQAGHNFYNV DMSYLKRLCG 60 TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR DQGSCGSCWA FGAVEAISDR 120 ICIHTNAHVS VEVSAEDLLT CCGSMCGDGC NGGYPAEAWN FWTRKGLVSG GLYESHVGCR 180 PYSIPPCEHH VNGSRPPCTG EGDTPKCSKI CEPGYSPTYK QDKHYGYNSY SVSNSEKDIM 240 AEIYKNGPVE GAFSVYSDFL LYKSGVYQHV TGEMMGGHAI RILGWGVENG TPYWLVANSW 300 NTDWGDNGFF KILRGQDHCG IESEVVAGIP RTDQYWEKI |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 8) (view all) | MESH:D002292
; Carcinoma, Renal Cell MESH:D018450 ; Disease Progression MESH:D005909 ; Glioblastoma MESH:D009135 ; Muscular Diseases MESH:D009336 ; Necrosis MESH:D009361 ; Neoplasm Invasiveness |
| DisGeNet (Curated) (count: 7) (view all) | C0007134; Renal Cell Carcinoma
C0017636; Glioblastoma C0026848; Myopathy C0027540; Necrosis C0027626; Neoplasm Invasiveness C0033578; Prostatic Neoplasms |
| HGMD (count: 1) | CM066015; Tropical calcific pancreatitis; Missense/nonsense
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| GWASdb (count: 2) | rs4839; Acne (severe); acne
rs1296023; Type 1 diabetes; type 1 diabetes mellitus |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 5) | 169 WTRKGLVSGGLYESH dbPAF
173 GLVSGGLYESHVGCR dbPAF 215 SKICEPGYSPTYKQD dbPAF 219 EPGYSPTYKQDKHYG dbPAF 33 LSDELVNYVNKRNTT dbPAF |
| Acetylation (count: 2) | 220 PGYSPTYKQDKHYGY PLMD
97 WPQCPTIKEIRDQGS PLMD |
| Ubiquitination (count: 3) | 220 PGYSPTYKQDKHYGY PLMD
223 SPTYKQDKHYGYNSY PLMD 237 YSVSNSEKDIMAEIY PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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