P07197

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession NFM_HUMAN; P07197;
Entrez ID 4741
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)
Gene Name NEFM; NEF3; NFM
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionNeurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
Sequence
(Fasta)		MSYTLDSLGN PSAYRRVTET RSSFSRVSGS PSSGFRSQSW SRGSPSTVSS SYKRSMLAPR 60
LAYSSAMLSS AESSLDFSQS SSLLNGGSGP GGDYKLSRSN EKEQLQGLND RFAGYIEKVH 120
YLEQQNKEIE AEIQALRQKQ ASHAQLGDAY DQEIRELRAT LEMVNHEKAQ VQLDSDHLEE 180
DIHRLKERFE EEARLRDDTE AAIRALRKDI EEASLVKVEL DKKVQSLQDE VAFLRSNHEE 240
EVADLLAQIQ ASHITVERKD YLKTDISTAL KEIRSQLESH SDQNMHQAEE WFKCRYAKLT 300
EAAEQNKEAI RSAKEEIAEY RRQLQSKSIE LESVRGTKES LERQLSDIEE RHNHDLSSYQ 360
DTIQQLENEL RGTKWEMARH LREYQDLLNV KMALDIEIAA YRKLLEGEET RFSTFAGSIT 420
GPLYTHRPPI TISSKIQKPK VEAPKLKVQH KFVEEIIEET KVEDEKSEME EALTAITEEL 480
AVSMKEEKKE AAEEKEEEPE AEEEEVAAKK SPVKATAPEV KEEEGEKEEE EGQEEEEEED 540
EGAKSDQAEE GGSEKEGSSE KEEGEQEEGE TEAEAEGEEA EAKEEKKVEE KSEEVATKEE 600
LVADAKVEKP EKAKSPVPKS PVEEKGKSPV PKSPVEEKGK SPVPKSPVEE KGKSPVPKSP 660
VEEKGKSPVS KSPVEEKAKS PVPKSPVEEA KSKAEVGKGE QKEEEEKEVK EAPKEEKVEK 720
KEEKPKDVPE KKKAESPVKE EAVAEVVTIT KSVKVHLEKE TKEEGKPLQQ EKEKEKAGGE 780
GGSEEEGSDK GAKGSRKEDI AVNGEVEGKE EVEQETKEKG SGREEEKGVV TNGLDLSPAD 840
EKKGGDKSEE KVVVTKTVEK ITSEGGDGAT KYITKSVTVT QKVEEHEETF EEKLVSTKKV 900
EKVTSHAIVK EVTQSD 917

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationAlzheimer's diseaseUS3321828286
[Reference]: Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs.
2Serine PhosphorylationAlzheimer's diseaseUS68520624930; 21828286
[Reference]: Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs.
3Serine PhosphorylationAlzheimer's diseaseUS73620624930; 21828286
[Reference]: We identified 13 hyperphosphorylated sites of NF-M; 9 Lys-Ser-Pro (KSP) sites; 2 variant motifs, Glu-Ser-Pro (ESP) Ser-736 and Leu-Ser-Pro (LSP) Ser-837; and 2 non-S/T-P motifs, Ser-783 and Ser-788. All the Ser/Thr residues are phosphorylated at significantly greater abundance in AD brain compared with control brain.
4Serine PhosphorylationAlzheimer's diseaseUS78320624930
[Reference]: We identified 13 hyperphosphorylated sites of NF-M; 9 Lys-Ser-Pro (KSP) sites; 2 variant motifs, Glu-Ser-Pro (ESP) Ser-736 and Leu-Ser-Pro (LSP) Ser-837; and 2 non-S/T-P motifs, Ser-783 and Ser-788. All the Ser/Thr residues are phosphorylated at significantly greater abundance in AD brain compared with control brain.
5Serine PhosphorylationAlzheimer's diseaseUS78820624930
[Reference]: We identified 13 hyperphosphorylated sites of NF-M; 9 Lys-Ser-Pro (KSP) sites; 2 variant motifs, Glu-Ser-Pro (ESP) Ser-736 and Leu-Ser-Pro (LSP) Ser-837; and 2 non-S/T-P motifs, Ser-783 and Ser-788. All the Ser/Thr residues are phosphorylated at significantly greater abundance in AD brain compared with control brain.?
6Serine PhosphorylationAlzheimer's diseaseUS83720624930
[Reference]: We identified 13 hyperphosphorylated sites of NF-M; 9 Lys-Ser-Pro (KSP) sites; 2 variant motifs, Glu-Ser-Pro (ESP) Ser-736 and Leu-Ser-Pro (LSP) Ser-837; and 2 non-S/T-P motifs, Ser-783 and Ser-788. All the Ser/Thr residues are phosphorylated at significantly greater abundance in AD brain compared with control brain.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)		MESH:D004715 ; Endometriosis
GWASdb
(count: 2)		rs1457266; Drug response to Risperidone; Null
rs1457266; Major depressive disorder; major depressive disorder

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 36)
(view all)		 226       ELDKKVQSLQDEVAF     dbPAF
23        RVTETRSSFSRVSGS     dbPAF
28        RSSFSRVSGSPSSGF     dbPAF
30        SFSRVSGSPSSGFRS     dbPAF
33        RVSGSPSSGFRSQSW     dbPAF
37        SPSSGFRSQSWSRGS     dbPAF
Ubiquitination
(count: 8)
(view all)		 118       RFAGYIEKVHYLEQQ     PLMD
259       SHITVERKDYLKTDI     PLMD
263       VERKDYLKTDISTAL     PLMD
271       TDISTALKEIRSQLE     PLMD
451       PKLKVQHKFVEEIIE     PLMD
751       AEVVTITKSVKVHLE     PLMD
Glycation
(count: 4)		 451       PKLKVQHKFVEEIIE     PLMD
632       KGKSPVPKSPVEEKG     PLMD
645       KGKSPVPKSPVEEKG     PLMD
658       KGKSPVPKSPVEEKG     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource