P07196

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	NFL_HUMAN; P07196;
Entrez ID	4747
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)
Gene Name	NEFL; NF68; NFL
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. Functional Description Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
Sequence (Fasta)	MSSFSYEPYY STSYKRRYVE TPRVHISSVR SGYSTARSAY SSYSAPVSSS LSVRRSYSSS 60 SGSLMPSLEN LDLSQVAAIS NDLKSIRTQE KAQLQDLNDR FASFIERVHE LEQQNKVLEA 120 ELLVLRQKHS EPSRFRALYE QEIRDLRLAA EDATNEKQAL QGEREGLEET LRNLQARYEE 180 EVLSREDAEG RLMEARKGAD EAALARAELE KRIDSLMDEI SFLKKVHEEE IAELQAQIQY 240 AQISVEMDVT KPDLSAALKD IRAQYEKLAA KNMQNAEEWF KSRFTVLTES AAKNTDAVRA 300 AKDEVSESRR LLKAKTLEIE ACRGMNEALE KQLQELEDKQ NADISAMQDT INKLENELRT 360 TKSEMARYLK EYQDLLNVKM ALDIEIAAYR KLLEGEETRL SFTSVGSITS GYSQSSQVFG 420 RSAYGGLQTS SYLMSTRSFP SYYTSHVQEE QIEVEETIEA AKAEEAKDEP PSEGEAEEEE 480 KDKEEAEEEE AAEEEEAAKE ESEEAKEEEE GGEGEEGEET KEAEEEEKKV EGAGEEQAAK 540 KKD 544 Fasta Sequence >P07196\|NEFL; NF68; NFL\|Homo sapiens (Human) MSSFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAKKKD

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Tropical spastic paraparesis		U	S103	19678766
1	[Reference]: Comparative study of CSF neurofilaments in HTLV-1-associated myelopathy/tropical spastic paraparesis and other neurological disorders.
2	Serine Phosphorylation	Tropical spastic paraparesis		U	S215	19678766
2	[Reference]: Comparative study of CSF neurofilaments in HTLV-1-associated myelopathy/tropical spastic paraparesis and other neurological disorders.
3	Serine Phosphorylation	Tropical spastic paraparesis		U	S221	19678766
3	[Reference]: Comparative study of CSF neurofilaments in HTLV-1-associated myelopathy/tropical spastic paraparesis and other neurological disorders.
4	Serine Phosphorylation	Tropical spastic paraparesis		U	S472	19678766
4	[Reference]: Comparative study of CSF neurofilaments in HTLV-1-associated myelopathy/tropical spastic paraparesis and other neurological disorders.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 2)	MESH:C537987 ; Charcot-Marie-Tooth disease, Type 1F MESH:C537994 ; Charcot-Marie-Tooth disease, Type 2E

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 18) (view all)	103 DLNDRFASFIERVHE dbPAF 14 EPYYSTSYKRRYVET dbPAF 154 RLAAEDATNEKQALQ dbPAF 21 YKRRYVETPRVHISS dbPAF 215 ELEKRIDSLMDEISF dbPAF 221 DSLMDEISFLKKVHE dbPAF 3 *****MSSFSYEPYY dbPAF 33 ISSVRSGYSTARSAY dbPAF 34 SSVRSGYSTARSAYS dbPAF 35 SVRSGYSTARSAYSS dbPAF 372 MARYLKEYQDLLNVK dbPAF 389 LDIEIAAYRKLLEGE dbPAF 424 QVFGRSAYGGLQTSS dbPAF 43 ARSAYSSYSAPVSSS dbPAF 432 GGLQTSSYLMSTRSF dbPAF 472 EAKDEPPSEGEAEEE dbPAF 56 SSLSVRRSYSSSSGS dbPAF 67 SSGSLMPSLENLDLS dbPAF
Ubiquitination (count: 5)	15 PYYSTSYKRRYVETP PLMD 157 AEDATNEKQALQGER PLMD 271 QYEKLAAKNMQNAEE PLMD 370 SEMARYLKEYQDLLN PLMD 91 KSIRTQEKAQLQDLN PLMD
Glycation (count: 1)	379 YQDLLNVKMALDIEI PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

IntAct