P07101

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession TY3H_HUMAN; P07101;
Entrez ID 7054
GenBank Protein ID NM_000360.3; NM_199292.2; NM_199293.2; XM_011520335.2;
GenBank Nucleotide ID NP_000351.2; NP_954986.2; NP_954987.2; XP_011518637.1;
Protein Name Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH)
Gene Name TH; TYH
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionPlays an important role in the physiology of adrenergic neurons.
Sequence
(Fasta)		MPTPDATTPQ AKGFRRAVSE LDAKQAEAIM VRGQGAPGPS LTGSPWPGTA APAASYTPTP 60
RSPRFIGRRQ SLIEDARKER EAAVAAAAAA VPSEPGDPLE AVAFEEKEGK AVLNLLFSPR 120
ATKPSALSRA VKVFETFEAK IHHLETRPAQ RPRAGGPHLE YFVRLEVRRG DLAALLSGVR 180
QVSEDVRSPA GPKVPWFPRK VSELDKCHHL VTKFDPDLDL DHPGFSDQVY RQRRKLIAEI 240
AFQYRHGDPI PRVEYTAEEI ATWKEVYTTL KGLYATHACG EHLEAFALLE RFSGYREDNI 300
PQLEDVSRFL KERTGFQLRP VAGLLSARDF LASLAFRVFQ CTQYIRHASS PMHSPEPDCC 360
HELLGHVPML ADRTFAQFSQ DIGLASLGAS DEEIEKLSTL YWFTVEFGLC KQNGEVKAYG 420
AGLLSSYGEL LHCLSEEPEI RAFDPEAAAV QPYQDQTYQS VYFVSESFSD AKDKLRSYAS 480
RIQRPFSVKF DPYTLAIDVL DSPQAVRRSL EGVQDELDTL AHALSAIG 529

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationProgressive supranuclear palsyDS9920892
[Reference]: TH isoform lacking S31 and S40 is overexpressed in PSP patients

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 15)
(view all)		MESH:D001927 ; Brain Diseases
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D002375 ; Catalepsy
MESH:D004409 ; Dyskinesia, Drug-Induced
MESH:D004421 ; Dystonia
MESH:D006331 ; Heart Diseases
GWASdb
(count: 5)		rs2070762; Coronary heart disease; coronary artery disease
rs6356; Type 1 diabetes; type 1 diabetes mellitus
rs7950050; LDL cholesterol; atherosclerosis|coronary artery disease
rs10770141; Type 1 diabetes; type 1 diabetes mellitus
rs10770141; Type 2 diabetes; type 2 diabetes mellitus

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 10)
(view all)		 118       AVLNLLFSPRATKPS     dbPAF
19        KGFRRAVSELDAKQA     dbPAF
230       PGFSDQVYRQRRKLI     dbPAF
3         *****MPTPDATTPQ     dbPAF
40        GQGAPGPSLTGSPWP     dbPAF
419       QNGEVKAYGAGLLSS     dbPAF
Sumoylation
(count: 1)		 474       SFSDAKDKLRSYASR     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource