P06730

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession IF4E_HUMAN; P06730;
Entrez ID 1977
GenBank Protein ID NM_001130678.2; NM_001130679.2; NM_001331017.1; NM_001968.4;
GenBank Nucleotide ID NP_001124150.1; NP_001124151.1; NP_001317946.1; NP_001959.1;
Protein Name Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)
Gene Name EIF4E; EIF4EL1; EIF4F
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionRecognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
Sequence
(Fasta)
MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL 60
RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ 120
QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENREAVTHIG 180
RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV 218

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationGastric cardiac adenocarcinomatumor tissueU23229050
[Reference]: The levels of phosphorylated eIF4E (peIF4E) were significantly higher in the tumors in comparison to the corresponding normal tissues (1.822 ? 0.63 vs. 0.997 ? 0.38, P<0.05), and the levels of p-eIF4E were closely correlated with lymph node metastasis (p<0.05).
2Serine PhosphorylationAcute lymphoblastic leukaemiaPS20923792164
[Reference]: MKK3/6-dependent activation of p38MAPK is required for the phosphorylation of eIF4E, thus initiating the translation of ER stress-related transcription factor ATF4. Upregulated ATF4 results in the transcriptional initiation of the apoptosis-related chop gene and autophagy-related map1lc3b gene, through which selenite links ER stress to apoptosis and autophagy during leukemia treatment
3Serine PhosphorylationProstate cancer/carcinoma/adenocarcinomaUS20920679199
[Reference]: eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.
4Serine PhosphorylationPathological scartumor tissueUS20923259313
[Reference]: The phosphorylation of eIF4E in pathological scar was higher than that in control group
5Serine PhosphorylationBlast crisis chronic myeloid leukemiaUS20923737503
[Reference]: We performed Western blot analysis on cell lysates obtained from primary CD34+ BC cells and found that total and phosphorylated (i.e., S209) eIF4E levels were increased by two and five fold, respectively, compared with normal CD34+ cord blood (CB) controls

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)
MESH:D001321 ; Autistic Disorder
MESH:D020522 ; Lymphoma, Mantle-Cell
MESH:D009361 ; Neoplasm Invasiveness
DisGeNet (Curated)
(count: 1)
C0334634; Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
GWASdb
(count: 1)
rs11727086; Urinary metabolites; kidney disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 13)
(view all)
11        VEPETTPTPNPPTTE     dbPAF
16        TPTPNPPTTEEEKTE     dbPAF
17        PTPNPPTTEEEKTES     dbPAF
183       VTHIGRVYKERLGLP     dbPAF
203       GYQSHADTATKSGST     dbPAF
209       DTATKSGSTTKNRFV     dbPAF
Acetylation
(count: 4)
108       MWEDEKNKRGGRWLI     PLMD
119       RWLITLNKQQRRSDL     PLMD
159       AVVNVRAKGDKIAIW     PLMD
162       NVRAKGDKIAIWTTE     PLMD
Ubiquitination
(count: 5)
119       RWLITLNKQQRRSDL     PLMD
162       NVRAKGDKIAIWTTE     PLMD
206       SHADTATKSGSTTKN     PLMD
36        ANPEHYIKHPLQNRW     PLMD
54        FFKNDKSKTWQANLR     PLMD
Sumoylation
(count: 5)
162       NVRAKGDKIAIWTTE     PLMD
206       SHADTATKSGSTTKN     PLMD
212       TKSGSTTKNRFVV**     PLMD
36        ANPEHYIKHPLQNRW     PLMD
49        RWALWFFKNDKSKTW     PLMD
Malonylation
(count: 3)
119       RWLITLNKQQRRSDL     PLMD
159       AVVNVRAKGDKIAIW     PLMD
206       SHADTATKSGSTTKN     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource