Tag | Content |
---|---|
UniProt Accession | IF4E_HUMAN; P06730; |
Entrez ID | 1977 |
GenBank Protein ID | NM_001130678.2; NM_001130679.2; NM_001331017.1; NM_001968.4; |
GenBank Nucleotide ID | NP_001124150.1; NP_001124151.1; NP_001317946.1; NP_001959.1; |
Protein Name | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) |
Gene Name | EIF4E; EIF4EL1; EIF4F |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. |
Sequence (Fasta) | MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL 60 RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ 120 QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENREAVTHIG 180 RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV 218 |
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Database | Annotation |
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CTD (Curated) (count: 3) | MESH:D001321
; Autistic Disorder MESH:D020522 ; Lymphoma, Mantle-Cell MESH:D009361 ; Neoplasm Invasiveness |
DisGeNet (Curated) (count: 1) | C0334634; Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse |
GWASdb (count: 1) | rs11727086; Urinary metabolites; kidney disease |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 13) (view all) | 11 VEPETTPTPNPPTTE dbPAF
16 TPTPNPPTTEEEKTE dbPAF 17 PTPNPPTTEEEKTES dbPAF 183 VTHIGRVYKERLGLP dbPAF 203 GYQSHADTATKSGST dbPAF 209 DTATKSGSTTKNRFV dbPAF |
Acetylation (count: 4) | 108 MWEDEKNKRGGRWLI PLMD
119 RWLITLNKQQRRSDL PLMD 159 AVVNVRAKGDKIAIW PLMD 162 NVRAKGDKIAIWTTE PLMD |
Ubiquitination (count: 5) | 119 RWLITLNKQQRRSDL PLMD
162 NVRAKGDKIAIWTTE PLMD 206 SHADTATKSGSTTKN PLMD 36 ANPEHYIKHPLQNRW PLMD 54 FFKNDKSKTWQANLR PLMD |
Sumoylation (count: 5) | 162 NVRAKGDKIAIWTTE PLMD
206 SHADTATKSGSTTKN PLMD 212 TKSGSTTKNRFVV** PLMD 36 ANPEHYIKHPLQNRW PLMD 49 RWALWFFKNDKSKTW PLMD |
Malonylation (count: 3) | 119 RWLITLNKQQRRSDL PLMD
159 AVVNVRAKGDKIAIW PLMD 206 SHADTATKSGSTTKN PLMD |
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