Tag | Content |
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UniProt Accession | S10A9_HUMAN; P06702; |
Entrez ID | 6280 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Protein S100-A9 (Calgranulin-B) (Calprotectin L1H subunit) (Leukocyte L1 complex heavy chain) (Migration inhibitory factor-related protein 14) (MRP-14) (p14) (S100 calcium-binding protein A9) |
Gene Name | S100A9; CAGB; CFAG; MRP14 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating l(view all) |
Sequence (Fasta) | MTCKMSQLER NIETIINTFH QYSVKLGHPD TLNQGEFKEL VRKDLQNFLK KENKNEKVIE 60 HIMEDLDTNA DKQLSFEEFI MLMARLTWAS HEKMHEGDEG PGHHHKPGLG EGTP 115 |
|
Database | Annotation |
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CTD (Curated) (count: 4) | MESH:D003110
; Colonic Neoplasms MESH:D007627 ; Keloid MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D012128 ; Respiratory Distress Syndrome, Adult |
PTM | Modification Sites |
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Phosphorylation (count: 4) | 113 KPGLGEGTP****** dbPAF
31 VKLGHPDTLNQGEFK dbPAF 68 HIMEDLDTNADKQLS dbPAF 75 TNADKQLSFEEFIML dbPAF |
Glycation (count: 1) | 38 TLNQGEFKELVRKDL PLMD |
Network | Interaction | ||
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A | B | Source | |