Tag | Content |
---|---|
UniProt Accession | CDK1_HUMAN; P06493; |
Entrez ID | 983 |
GenBank Protein ID | NM_001320918.1; NM_001786.4; NM_033379.4; XM_005270303.3; |
GenBank Nucleotide ID | NP_001307847.1; NP_001777.1; NP_203698.1; XP_005270360.1; |
Protein Name | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) |
Gene Name | CDK1; CDC2; CDC28A; CDKN1; P34CDC2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR(view all) |
Sequence (Fasta) | MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH 60 PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKSYLY QILQGIVFCH 120 SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR 180 YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT 240 FPKWKPGSLA SHVKNLDENG LDLLSKMLIY DPAKRISGKM ALNHPYFNDL DNQIKKM 298 |
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Database | Annotation |
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CTD (Curated) (count: 2) | MESH:D008106
; Liver Cirrhosis, Experimental MESH:D016403 ; Lymphoma, Large B-Cell, Diffuse |
GWASdb (count: 5) | rs744383; Cocaine dependence; cocaine dependence
rs3213056; Reading and spelling; reading disorder|cognitive disorder|language disorder|speech disorder rs2939950; Odorant perception; sensory system disease rs2448363; Cocaine dependence; cocaine dependence rs2456778; Cocaine dependence; cocaine dependence |
PTM | Modification Sites |
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Phosphorylation (count: 24) (view all) | 121 QGIVFCHSRRVLHRD dbPAF
14 IEKIGEGTYGVVYKG dbPAF 141 LLIDDKGTIKLADFG dbPAF 15 EKIGEGTYGVVYKGR dbPAF 160 FGIPIRVYTHEVVTL dbPAF 161 GIPIRVYTHEVVTLW dbPAF |
Acetylation (count: 13) (view all) | 130 RVLHRDLKPQNLLID PLMD
139 QNLLIDDKGTIKLAD PLMD 143 IDDKGTIKLADFGLA PLMD 20 GTYGVVYKGRHKTTG PLMD 201 FAELATKKPLFHGDS PLMD 254 GSLASHVKNLDENGL PLMD |
Ubiquitination (count: 21) (view all) | 130 RVLHRDLKPQNLLID PLMD
139 QNLLIDDKGTIKLAD PLMD 143 IDDKGTIKLADFGLA PLMD 20 GTYGVVYKGRHKTTG PLMD 201 FAELATKKPLFHGDS PLMD 238 VESLQDYKNTFPKWK PLMD |
Sumoylation (count: 15) (view all) | 130 RVLHRDLKPQNLLID PLMD
139 QNLLIDDKGTIKLAD PLMD 20 GTYGVVYKGRHKTTG PLMD 201 FAELATKKPLFHGDS PLMD 238 VESLQDYKNTFPKWK PLMD 24 VVYKGRHKTTGQVVA PLMD |
Succinylation (count: 1) | 20 GTYGVVYKGRHKTTG PLMD |