| Tag | Content |
|---|---|
| UniProt Accession | PRGR_HUMAN; P06401; |
| Entrez ID | 5241 |
| GenBank Protein ID | NM_000926.4; NM_001202474.3; NM_001271161.2; NM_001271162.1; |
| GenBank Nucleotide ID | NP_000917.3; NP_001189403.1; NP_001258090.1; NP_001258091.1; |
| Protein Name | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) |
| Gene Name | PGR; NR3C3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.;Isoform A: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.;Isoform B: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.;Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
| Sequence (Fasta) | MTELKAKGPR APHVAGGPPS PEVGSPLLCR PAAGPFPGSQ TSDTLPEVSA IPISLDGLLF 60 PRPCQGQDPS DEKTQDQQSL SDVEGAYSRA EATRGAGGSS SSPPEKDSGL LDSVLDTLLA 120 PSGPGQSQPS PPACEVTSSW CLFGPELPED PPAAPATQRV LSPLMSRSGC KVGDSSGTAA 180 AHKVLPRGLS PARQLLLPAS ESPHWSGAPV KPSPQAAAVE VEEEDGSESE ESAGPLLKGK 240 PRALGGAAAG GGAAAVPPGA AAGGVALVPK EDSRFSAPRV ALVEQDAPMA PGRSPLATTV 300 MDFIHVPILP LNHALLAART RQLLEDESYD GGAGAASAFA PPRSSPCASS TPVAVGDFPD 360 CAYPPDAEPK DDAYPLYSDF QPPALKIKEE EEGAEASARS PRSYLVAGAN PAAFPDFPLG 420 PPPPLPPRAT PSRPGEAAVT AAPASASVSS ASSSGSTLEC ILYKAEGAPP QQGPFAPPPC 480 KAPGASGCLL PRDGLPSTSA SAAAAGAAPA LYPALGLNGL PQLGYQAAVL KEGLPQVYPP 540 YLNYLRPDSE ASQSPQYSFE SLPQKICLIC GDEASGCHYG VLTCGSCKVF FKRAMEGQHN 600 YLCAGRNDCI VDKIRRKNCP ACRLRKCCQA GMVLGGRKFK KFNKVRVVRA LDAVALPQPV 660 GVPNESQALS QRFTFSPGQD IQLIPPLINL LMSIEPDVIY AGHDNTKPDT SSSLLTSLNQ 720 LGERQLLSVV KWSKSLPGFR NLHIDDQITL IQYSWMSLMV FGLGWRSYKH VSGQMLYFAP 780 DLILNEQRMK ESSFYSLCLT MWQIPQEFVK LQVSQEEFLC MKVLLLLNTI PLEGLRSQTQ 840 FEEMRSSYIR ELIKAIGLRQ KGVVSSSQRF YQLTKLLDNL HDLVKQLHLY CLNTFIQSRA 900 LSVEFPEMMS EVIAAQLPKI LAGMVKPLLF HKK 934 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 11) (view all) | MESH:D000230
; Adenocarcinoma MESH:D001943 ; Breast Neoplasms MESH:D002277 ; Carcinoma MESH:D016889 ; Endometrial Neoplasms MESH:D004715 ; Endometriosis MESH:D015674 ; Mammary Neoplasms, Animal |
| HGMD (count: 4) | CN044488; Endometriosis, association with ?; Gross insertions
CM043326; Ovarian cancer, risk, association with; Missense/nonsense CM984071; Insensitivity to mifepristone; Missense/nonsense CR022117; Endometrial cancer, increased risk, association; Regulatory |
| GWASdb (count: 16) (view all) | rs1046982; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension
rs11224571; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis rs11224571; LDL cholesterol; atherosclerosis|coronary artery disease rs635984; Endometriosis; endometriosis rs660541; Endometriosis; endometriosis rs495997; Abdominal aortic aneurysm; abdominal aortic aneurysm |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 23) (view all) | 101 RGAGGSSSSPPEKDS dbPAF
102 GAGGSSSSPPEKDSG dbPAF 130 GPGQSQPSPPACEVT dbPAF 162 PATQRVLSPLMSRSG dbPAF 190 KVLPRGLSPARQLLL dbPAF 20 HVAGGPPSPEVGSPL dbPAF |
| Ubiquitination (count: 1) | 388 QPPALKIKEEEEGAE PLMD |
| Sumoylation (count: 3) | 388 QPPALKIKEEEEGAE PLMD
531 GYQAAVLKEGLPQVY PLMD 7 *MTELKAKGPRAPHV PLMD |
| Glycation (count: 2) | 171 LMSRSGCKVGDSSGT PLMD
183 SGTAAAHKVLPRGLS PLMD |
| Methylation (count: 1) | 464 TLECILYKAEGAPPQ PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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