Num | PTM | Disease | Cell Type | Type | PTM Site | PMID |
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1 | Phosphorylation | Colon cancer/carcinoma | | D | | 11032757 |
[Reference]: There was a 2.4-fold decrease in the ratio of hyperphosphorylated pRb (ppRb) to hypophosphorylated pRb, as well as a 60-75% decrease in cdk 2- and cdk 4-specific phosphorylated pRb proteins. |
|
2 | Phosphorylation | Head and neck squamous cell carcinoma | | P | | 23414419 |
[Reference]: P276-00 treatment suppressed cell proliferation through inhibition of CCND1 expression, reduced phosphorylation of retinoblastoma protein and abrogative transcription of E2F1 gene targets |
|
3 | Phosphorylation | Lung cancer/carcinoma | | P | | 9393586 |
[Reference]: The positive correlation between the expressions of RB protein and cyclin A suggests that RB protein in most RB(+) lung cancer cell lines is a target of cyclin-A-dependent kinase and that the tumor-suppressor function may be inactivated by phosphorylation. |
|
4 | Phosphorylation | Breast cancer/tumor/carcinoma | | U | | 10860819; 23686806 |
[Reference]: Bone morphogenetic protein-2 blocks MDA MB 231 human breast cancer cell proliferation by inhibiting cyclin-dependent kinase-mediated retinoblastoma protein phosphorylation. |
|
5 | Phosphorylation | Pancreatic cancer/carcinoma/adenocarcinoma | | U | | 24107447; 24334458 |
[Reference]: Here, we found that proliferating pancreatic cancer cells (PCCs) from human PDAC patients and multiple murine models of PDAC (mPDAC) often exhibit abundant levels of phosphorylated retinoblastoma 1 (RB) and Smad2 |
|
6 | Phosphorylation | Acute lymphoblastic leukaemia | | U | | 11380466 |
[Reference]: In p15- and p16-null K562 cells transfected with a tetracycline-inducible p15 cDNA construct, induction of p15 transcripts and protein was accompanied by decreased growth rates, decreased S-phase fraction, decreased retinoblastoma protein phosphorylation, and markedly reduced levels of DHFR transcripts and protein. |
|
7 | Phosphorylation | Neuroblastoma | | U | | 16824683; 10644979 |
[Reference]: Membrane depolarization stimulates the proliferation of SH-SY5Y human neuroblastoma cells by increasing retinoblastoma protein (RB) phosphorylation through the activation of cyclin-dependent kinase 2 (Cdk2). |
|
8 | Phosphorylation | Retinoblastoma | | U | | 11900540 |
[Reference]: Overexpression of gankyrin not only led to increased phosphorylation of Rb and activation of E2F-1 in U2-OS cells but also caused cell transformation in NIH3T3 cells. |
|
9 | Phosphorylation | Ulcerative colitis | | U | | 23967107 |
[Reference]: RB phosphorylation was significantly greater in colon samples from patients with CD compared with UC (p<0.005). |
|
10 | Phosphorylation | Crohn's disease | | U | | 23967107 |
[Reference]: RB phosphorylation was significantly greater in colon samples from patients with CD compared with UC (p<0.005). |
|
11 | Phosphorylation | Nasopharyngeal carcinoma | | U | | 18697201 |
[Reference]: While LTF treatment downregulated expression of cyclin D1 and phosphorylation of retinoblastoma protein (Rb), expression of p21 and p27 in 5-8F NPC cells was enhanced. |
|
12 | Serine Phosphorylation | Breast cancer/tumor/carcinoma | | U | S249 | 17599043 |
[Reference]: This was accompanied by the sustained expression of cyclin D1 despite progestin treatment, and increased levels of retinoblastoma (Rb) phosphorylation at sites targeted by cyclin D1-Cdk4 (Ser249/Thr252). |
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13 | Threonine Phosphorylation | Breast cancer/tumor/carcinoma | | U | T252 | 17599043 |
[Reference]: MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts. |
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14 | Threonine Phosphorylation | Ovarian cancer/carcinoma | | U | T356 | 28319064 |
[Reference]: OCT4 controls mitotic stability and inactivates the RB tumor suppressor pathway to enhance ovarian cancer aggressiveness. |
|
15 | Threonine Phosphorylation | Squamous cell carcinoma | | U | T356 | 26265441 |
[Reference]: these data suggest such agents may merit evaluation in HPV-negative SCCHN, specifically in cases associated with high pT356RB1. |
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16 | Serine Phosphorylation | Pancreatic cancer/carcinoma/adenocarcinoma | tumor tissue | P | S780 | 23408967 |
[Reference]: Consistent with previous studies (reviewed in [2]), pancreatic cancer cells showed phosphorylation of Rb protein (p-RbS780, p-RbS807/811 |
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17 | Serine Phosphorylation | Prostate cancer/carcinoma/adenocarcinoma | | P | S780 | 16648554 |
[Reference]: Oral intake of apigenin resulted in dose-dependent (a) increase in the protein expression of WAF1/p21, KIP1/p27, INK4a/p16, and INK4c/p18; (b) down-modulation of the protein expression of cyclins D1, D2, and E; and cyclin-dependent kinases (cdk), cdk2, cdk4, and cdk6; (c) decrease in retinoblastoma phosphorylation at serine 780; (d) increase in the binding of cyclin D1 toward WAF1/p21 and KIP1/p27; and (e) decrease in the binding of cyclin E toward cdk2 in both types of tumors. |
|
18 | Serine Phosphorylation | Hepatocellular carcinoma/Hepatocarcinoma/Hepatoma | | U | S780 | 15349907 |
[Reference]: pRb phosphorylated at serine(Ser) 780 was detected more frequently in p18INK4C - negative than in p18INK4C - positive HCCs. |
|
19 | Serine Phosphorylation | Skin cancer | | A | S795 | 23888052 |
[Reference]: It caused loss of retinoblastoma phosphorylation at both Ser-795 and Ser-807/811, the preferred sites phosphorylated by Cdk4/6 and Cdk2, respectively. |
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20 | Serine Phosphorylation | Melanoma | | U | S795 | 15502804 |
[Reference]: phosphorylation increases as goes from melanocytic nevus to metastatic tumor; increased p-Rb correlates with a worse prognosis |
|
21 | Tyrosine Phosphorylation | Chronic myelogenous leukemia/Chronic myeloid leukemia | | P | Y805 | 16158058 |
[Reference]: We also show that ectopic expression of Rb induces apoptosis in Abl-dependent tumor cells by inhibiting the Abl tyrosine kinase activity, and that Rb-induced apoptosis is compromised by Abl-catalysed phosphorylation of Rb at Y805.? |
|
22 | Serine Phosphorylation | Skin cancer | | A | S807/811 | 23888052 |
[Reference]: It caused loss of retinoblastoma phosphorylation at both Ser-795 and Ser-807/811, the preferred sites phosphorylated by Cdk4/6 and Cdk2, respectively. |
|
23 | Serine Phosphorylation | Pancreatic cancer/carcinoma/adenocarcinoma | tumor tissue | P | S807/811 | 23408967 |
[Reference]: Consistent with previous studies (reviewed in [2]), pancreatic cancer cells showed phosphorylation of Rb protein (p-RbS780, p-RbS807/811 |
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24 | Serine Phosphorylation | Neuroendocrine cancer/carcinoma | | P | S807 | 24135281 |
[Reference]: Prevention of Rb phosphorylation at Ser807/Ser811 attenuated MTC proliferation |
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25 | Serine Phosphorylation | Bladder cancer | | P | S807/811 | 22787429 |
[Reference]: RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation |
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26 | Serine Phosphorylation | Ovarian cancer/carcinoma | | U | S807 | 28319064 |
[Reference]: OCT4 controls mitotic stability and inactivates the RB tumor suppressor pathway to enhance ovarian cancer aggressiveness. |
|
27 | Serine Phosphorylation | Melanoma | | U | S807 | 10969768; 15502804 |
[Reference]: Phosphorylation increases as goes from melanocytic nevus to metastatic tumor; increased p-Rb correlates with a worse prognosis |
|
28 | Lysine Methylation | Bladder cancer | | P | K810 | 22787429 |
[Reference]: SMYD2 is an important oncoprotein in various types of cancer, and SMYD2-dependent RB1 methylation at lysine 810 promotes cell cycle progression of cancer cells |
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29 | Serine Phosphorylation | Neuroendocrine cancer/carcinoma | | P | S811 | 24135281 |
[Reference]: Prevention of Rb phosphorylation at Ser807/Ser811 attenuated MTC proliferation |
|
30 | Dephosphorylation | Breast cancer/tumor/carcinoma | cell line | U | T821 | 10353599; 22895174 |
[Reference]: Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition |
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