| Tag | Content |
|---|---|
| UniProt Accession | K1C18_HUMAN; P05783; |
| Entrez ID | 3875 |
| GenBank Protein ID | NM_000224.2; NM_199187.1; |
| GenBank Nucleotide ID | NP_000215.1; NP_954657.1; |
| Protein Name | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) |
| Gene Name | KRT18; CYK18; PIG46 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
| Sequence (Fasta) | MSFTTRSTFS TNYRSLGSVQ APSYGARPVS SAASVYAGAG GSGSRISVSR STSFRGGMGS 60 GGLATGIAGG LAGMGGIQNE KETMQSLNDR LASYLDRVRS LETENRRLES KIREHLEKKG 120 PQVRDWSHYF KIIEDLRAQI FANTVDNARI VLQIDNARLA ADDFRVKYET ELAMRQSVEN 180 DIHGLRKVID DTNITRLQLE TEIEALKEEL LFMKKNHEEE VKGLQAQIAS SGLTVEVDAP 240 KSQDLAKIMA DIRAQYDELA RKNREELDKY WSQQIEESTT VVTTQSAEVG AAETTLTELR 300 RTVQSLEIDL DSMRNLKASL ENSLREVEAR YALQMEQLNG ILLHLESELA QTRAEGQRQA 360 QEYEALLNIK VKLEAEIATY RRLLEDGEDF NLGDALDSSN SMQTIQKTTT RRIVDGKVVS 420 ETNDTKVLRH 431 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 7) (view all) | MESH:D001943
; Breast Neoplasms MESH:D056486 ; Chemical and Drug Induced Liver Injury MESH:D008103 ; Liver Cirrhosis MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D017114 ; Liver Failure, Acute MESH:D008113 ; Liver Neoplasms |
| DisGeNet (Curated) (count: 8) (view all) | C0023890; Liver Cirrhosis
C0023893; Liver Cirrhosis, Experimental C0023903; Liver neoplasms C0027540; Necrosis C0162557; Liver Failure, Acute C1458155; Mammary Neoplasms |
| GWASdb (count: 1) | rs7308151; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 59) (view all) | 10 FTTRSTFSTNYRSLG dbPAF
100 SYLDRVRSLETENRR dbPAF 11 TTRSTFSTNYRSLGS dbPAF 110 TENRRLESKIREHLE dbPAF 127 GPQVRDWSHYFKIIE dbPAF 129 QVRDWSHYFKIIEDL dbPAF |
| Acetylation (count: 10) (view all) | 111 ENRRLESKIREHLEK PLMD
131 RDWSHYFKIIEDLRA PLMD 167 AADDFRVKYETELAM PLMD 187 NDIHGLRKVIDDTNI PLMD 214 KEELLFMKKNHEEEV PLMD 222 KNHEEEVKGLQAQIA PLMD |
| Ubiquitination (count: 17) (view all) | 131 RDWSHYFKIIEDLRA PLMD
167 AADDFRVKYETELAM PLMD 187 NDIHGLRKVIDDTNI PLMD 207 ETEIEALKEELLFMK PLMD 214 KEELLFMKKNHEEEV PLMD 215 EELLFMKKNHEEEVK PLMD |
| Sumoylation (count: 7) (view all) | 167 AADDFRVKYETELAM PLMD
187 NDIHGLRKVIDDTNI PLMD 207 ETEIEALKEELLFMK PLMD 247 PKSQDLAKIMADIRA PLMD 372 ALLNIKVKLEAEIAT PLMD 417 TRRIVDGKVVSETND PLMD |
| Glycation (count: 1) | 81 MGGIQNEKETMQSLN PLMD |
| Malonylation (count: 1) | 187 NDIHGLRKVIDDTNI PLMD |
| Succinylation (count: 5) | 187 NDIHGLRKVIDDTNI PLMD
247 PKSQDLAKIMADIRA PLMD 317 LDSMRNLKASLENSL PLMD 417 TRRIVDGKVVSETND PLMD 426 VSETNDTKVLRH*** PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |