Tag | Content |
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UniProt Accession | KPCB_HUMAN; P05771; |
Entrez ID | 5579 |
GenBank Protein ID | NM_002738.6; NM_212535.2; |
GenBank Nucleotide ID | NP_002729.2; NP_997700.1; |
Protein Name | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) |
Gene Name | PRKCB; PKCB; PRKCB1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser(view all) |
Sequence (Fasta) | MADPAAGPPP SEGEESTVRF ARKGALRQKN VHEVKNHKFT ARFFKQPTFC SHCTDFIWGF 60 GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPASDDPRS KHKFKIHTYS SPTFCDHCGS 120 LLYGLIHQGM KCDTCMMNVH KRCVMNVPSL CGTDHTERRG RIYIQAHIDR DVLIVLVRDA 180 KNLVPMDPNG LSDPYVKLKL IPDPKSESKQ KTKTIKCSLN PEWNETFRFQ LKESDKDRRL 240 SVEIWDWDLT SRNDFMGSLS FGISELQKAS VDGWFKLLSQ EEGEYFNVPV PPEGSEANEE 300 LRQKFERAKI SQGTKVPEEK TTNTVSKFDN NGNRDRMKLT DFNFLMVLGK GSFGKVMLSE 360 RKGTDELYAV KILKKDVVIQ DDDVECTMVE KRVLALPGKP PFLTQLHSCF QTMDRLYFVM 420 EYVNGGDLMY HIQQVGRFKE PHAVFYAAEI AIGLFFLQSK GIIYRDLKLD NVMLDSEGHI 480 KIADFGMCKE NIWDGVTTKT FCGTPDYIAP EIIAYQPYGK SVDWWAFGVL LYEMLAGQAP 540 FEGEDEDELF QSIMEHNVAY PKSMSKEAVA ICKGLMTKHP GKRLGCGPEG ERDIKEHAFF 600 RYIDWEKLER KEIQPPYKPK ARDKRDTSNF DKEFTRQPVE LTPTDKLFIM NLDQNEFAGF 660 SYTNPEFVIN V 672 |
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Database | Annotation |
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Cancer Gene Census | adult T-cell lymphoma-leukaemia |
CTD (Curated) (count: 8) (view all) | MESH:D001321
; Autistic Disorder MESH:D006332 ; Cardiomegaly MESH:D015179 ; Colorectal Neoplasms MESH:D003924 ; Diabetes Mellitus, Type 2 MESH:D006943 ; Hyperglycemia MESH:D015459 ; Leukemia-Lymphoma, Adult T-Cell |
HGMD (count: 1) | CR080772; Reduced promoter activity, association with; Regulatory
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GWASdb (count: 38) (view all) | rs7404095; Inflammatory bowel disease; inflammatory bowel disease
rs7404095; Primary sclerosing cholangitis; sclerosing cholangitis rs7404005; Type 2 diabetes; type 2 diabetes mellitus rs3826261; Glycemic traits (pregnancy); type 2 diabetes mellitus rs9806904; Serum metabolites; Null rs8057472; Multiple complex diseases; Null |
PTM | Modification Sites |
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Phosphorylation (count: 26) (view all) | 11 PAAGPPPSEGEESTV dbPAF
120 TFCDHCGSLLYGLIH dbPAF 123 DHCGSLLYGLIHQGM dbPAF 134 HQGMKCDTCMMNVHK dbPAF 16 PPSEGEESTVRFARK dbPAF 17 PSEGEESTVRFARKG dbPAF |
Acetylation (count: 5) | 197 GLSDPYVKLKLIPDP PLMD
199 SDPYVKLKLIPDPKS PLMD 216 KQKTKTIKCSLNPEW PLMD 573 KEAVAICKGLMTKHP PLMD 76 VCCFVVHKRCHEFVT PLMD |
Ubiquitination (count: 10) (view all) | 141 TCMMNVHKRCVMNVP PLMD
199 SDPYVKLKLIPDPKS PLMD 232 ETFRFQLKESDKDRR PLMD 236 FQLKESDKDRRLSVE PLMD 29 RKGALRQKNVHEVKN PLMD 327 KTTNTVSKFDNNGNR PLMD |
Sumoylation (count: 1) | 181 IVLVRDAKNLVPMDP PLMD |
Glycation (count: 1) | 375 YAVKILKKDVVIQDD PLMD |