Tag | Content |
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UniProt Accession | KPCA_RAT; P05696; |
Entrez ID | 24680 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) |
Gene Name | Prkca; Pkca |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and ne(view all) |
Sequence (Fasta) | MADVYPANDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF 60 GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS 120 LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVTD EKLHVTVRDA 180 KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL 240 SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNVE 300 LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG 360 TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV 420 NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA 480 DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG 540 EDEDELFQSI MEHNVSYPKS LSKEAVSICK GLMTKHPAKR LGCGPEGERD VREHAFFRRI 600 DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN 660 PQFVHPILQS AV 673 |
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Database | Annotation |
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CTD (Curated) (count: 6) | MESH:D059366
; Asthma, Occupational MESH:D006332 ; Cardiomegaly MESH:D018500 ; Diabetes Insipidus, Nephrogenic MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D007414 ; Intestinal Neoplasms MESH:D011141 ; Polyuria |
PTM | Modification Sites |
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Phosphorylation (count: 19) (view all) | 13 PANDSTASQDVANRF dbPAF
192 PMDPNGLSDPYVKLK dbPAF 195 PNGLSDPYVKLKLIP dbPAF 226 LNPQWNESFTFKLKP dbPAF 234 FTFKLKPSDKDRRLS dbPAF 241 SDKDRRLSVEIWDWD dbPAF |
Acetylation (count: 2) | 197 GLSDPYVKLKLIPDP PLMD
38 VHEVKDHKFIARFFK PLMD |