Tag | Content |
---|---|
UniProt Accession | JUN_MOUSE; P05627; |
Entrez ID | 16476 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Transcription factor AP-1 (AH119) (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (Jun A) |
Gene Name | Jun |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells (By similarity). |
Sequence (Fasta) | MTAKMETTFY DDALNASFLQ SESGAYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL 60 LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE 120 LHSQNTLPSV TSAAQPVSGA GMVAPAVASV AGAGGGGGYS ASLHSEPPVY ANLSNFNPGA 180 LSSGGGAPSY GAAGLAFPSQ PQQQQQPPQP PHHLPQQIPV QHPRLQALKE EPQTVPEMPG 240 ETPPLSPIDM ESQERIKAER KRMRNRIAAS KCRKRKLERI ARLEEKVKTL KAQNSELAST 300 ANMLREQVAQ LKQKVMNHVN SGCQLMLTQQ LQTF 335 |
|
Database | Annotation |
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CTD (Curated) (count: 20) (view all) | MESH:D001171
; Arthritis, Juvenile MESH:D001930 ; Brain Injuries MESH:D002545 ; Brain Ischemia MESH:D001943 ; Breast Neoplasms MESH:D006528 ; Carcinoma, Hepatocellular MESH:D002471 ; Cell Transformation, Neoplastic |
PTM | Modification Sites |
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Phosphorylation (count: 12) (view all) | 242 VPEMPGETPPLSPID dbPAF
246 PGETPPLSPIDMESQ dbPAF 252 LSPIDMESQERIKAE dbPAF 58 PHLRAKNSDLLTSPD dbPAF 62 AKNSDLLTSPDVGLL dbPAF 63 KNSDLLTSPDVGLLK dbPAF |
Acetylation (count: 1) | 56 LKPHLRAKNSDLLTS PLMD |
Sumoylation (count: 2) | 229 HPRLQALKEEPQTVP PLMD
257 MESQERIKAERKRMR PLMD |