P05627

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession JUN_MOUSE; P05627;
Entrez ID 16476
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Transcription factor AP-1 (AH119) (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (Jun A)
Gene Name Jun
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionTranscription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells (By similarity).
Sequence
(Fasta)
MTAKMETTFY DDALNASFLQ SESGAYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL 60
LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE 120
LHSQNTLPSV TSAAQPVSGA GMVAPAVASV AGAGGGGGYS ASLHSEPPVY ANLSNFNPGA 180
LSSGGGAPSY GAAGLAFPSQ PQQQQQPPQP PHHLPQQIPV QHPRLQALKE EPQTVPEMPG 240
ETPPLSPIDM ESQERIKAER KRMRNRIAAS KCRKRKLERI ARLEEKVKTL KAQNSELAST 300
ANMLREQVAQ LKQKVMNHVN SGCQLMLTQQ LQTF 335

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationMelanomaUS6310851065
[Reference]: Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation.
2Serine PhosphorylationMelanomaUS7310851065
[Reference]: Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 20)
(view all)
MESH:D001171 ; Arthritis, Juvenile
MESH:D001930 ; Brain Injuries
MESH:D002545 ; Brain Ischemia
MESH:D001943 ; Breast Neoplasms
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D002471 ; Cell Transformation, Neoplastic

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 12)
(view all)
242       VPEMPGETPPLSPID     dbPAF
246       PGETPPLSPIDMESQ     dbPAF
252       LSPIDMESQERIKAE     dbPAF
58        PHLRAKNSDLLTSPD     dbPAF
62        AKNSDLLTSPDVGLL     dbPAF
63        KNSDLLTSPDVGLLK     dbPAF
Acetylation
(count: 1)
56        LKPHLRAKNSDLLTS     PLMD
Sumoylation
(count: 2)
229       HPRLQALKEEPQTVP     PLMD
257       MESQERIKAERKRMR     PLMD